Project Report No. 63, Site Index Equations for Loblolly and Slash Pine Plantations in East Texas, Update: Fall 2000

This update utilizes height-age pairs measured from 1982- 1999. As a result, the number.of observations available for analysis is 1,900 loblolly and 852 slash. It is anticipated that the equations in this Fall 2000 update may quantify the productivity of East Texas loblolly and slash pine plantations in a more accurate and reliable manner than the eight previous sets of equations

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

PURPOSE: To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs). METHODS: Relative regional expression of FcRn and localization in human intestinal mucosa by RT-PCR, ELISA & immunohistochemistry. Transcytosis of full-length mAbs (sandwich ELISA-based detection) across human intestinal segments mounted in Ussing-type chambers, human intestinal (caco-2) cell monolayers grown in transwells, and serum levels after regional intestinal delivery in isoflurane-anesthetized cynomolgus monkeys. RESULTS: In human intestine, there was an increasing proximal-distal gradient of mucosal FcRn mRNA and protein expression. In cynomolgus, serum mAb levels were greater after ileum-proximal colon infusion than after administration to stomach or proximal small intestine (1–5 mg/kg). Serum levels of wild-type mAb dosed into ileum/proximal colon (2 mg/kg) were 124 ± 104 ng/ml (n = 3) compared to 48 ± 48 ng/ml (n = 2) after a non-FcRn binding variant. In vitro, mAb transcytosis in polarized caco-2 cell monolayers and was not enhanced by increased apical cell surface IgG binding to FcRn. An unexpected finding in primate small intestine, was intense FcRn expression in enteroendocrine cells (chromagranin A, GLP-1 and GLP-2 containing). CONCLUSIONS: In adult primates, FcRn is expressed more highly in distal intestinal epithelial cells. However, mAb delivery to that region results in low serum levels, in part because apical surface FcRn binding does not influence mAb transcytosis. High FcRn expression in enteroendocrine cells could provide a novel means to target mAbs for metabolic diseases after systemic administration

Quitting Versus Failing

What\u27s the difference between quitting and failing? How do you know when to keep pushing forward versus giving up or starting over? In this engaging talk from serial entrepreneur Josh Mabus learn the difference between quitting and failing. Josh has used his varied experiences to bring a holistic approach to raising the creative bar in north Mississippi. Journalist, writer, designer, actor, director, videographer, builder, maker, doer — he uses strategy to focus all facets of marketing into winning results for clients. His advertising agency, Mabus Agency, has grown quickly since its formation at the start of a significant economic recession. An avid supporter of Mississippi’s startup culture, Josh is first in line to mentor entrepreneurs at any stage. Josh’s two part mission: to help people and to raise the creative bar manifests itself in many ways, but his core mantra remains the same: “Whatever you’re going to make, make a difference. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/ted

Data Science in San Francisco: Predicting At-Risk Restaurants

San Francisco is one of the most popular cities in the US and is recorded to have the highest number of restaurants per capita than any other major US city. However, this creates a problem for San Francisco’s health inspectors because it makes it harder to track and maintain the quality of these restaurants. In our research, we will address this issue and propose a way to facilitate finding the restaurants that have a higher need of inspection through social media.Since social media has become prevalent in our society, it can be used to provide valuable information previously not available. Social Media is not only used to connect to friends and post personal information, but also write reviews of businesses, movies, or restaurants. Customers who take the time to write a review on a social media platform generally provide a more genuine opinion rather than customers who were asked to write a review. Taking this in to consideration, customer reviews in social media like Yelp would provide a more accurate dataset rather than customers who were asked to fill out a survey.  Our work involves taking a dataset of San Francisco restaurant reviews provided on Yelp to predict which restaurants have a higher need of a health inspection. We will present various graphs, implemented through R Studio to visualize and explain our results