Associations between vertebral fractures, increased thoracic kyphosis, a flexed posture and falls in older adults:a prospective cohort study

Background: Vertebral fractures, an increased thoracic kyphosis and a flexed posture are associated with falls. However, this was not confirmed in prospective studies. We performed a prospective cohort study to investigate the association between vertebral fractures, increased thoracic kyphosis and/or flexed posture with future fall incidents in older adults within the next year. Methods: Patients were recruited at a geriatric outpatient clinic. Vertebral fractures were evaluated on lateral radiographs of the spine with the semi-quantitative method of Genant; the degree of thoracic kyphosis was assessed with the Cobb angle. The occiput-to-wall distance was used to determine a flexed posture. Self-reported falls were prospectively registered by monthly phone contact for the duration of 12 months. Results: Fifty-one older adults were included; mean age was 79 years (SD = 4.8). An increased thoracic kyphosis was independently associated with future falls (OR 2.13; 95% CI 1.10-4.51). Prevalent vertebral fractures had a trend towards significancy (OR 3.67; 95% CI 0.85-15.9). A flexed posture was not significantly associated with future falls. Conclusion: Older adults with an increased thoracic kyphosis are more likely to fall within the next year. We suggest clinical attention for underlying causes. Because patients with increased thoracic curvature of the spine might have underlying osteoporotic vertebral fractures, clinicians should be aware of the risk of a new fracture

Аксіологічні виміри душпастирства у творах Іоана Золотоустого

Стаття Світлани Білоус "Аксіологічні виміри душпастирства у творах Іоана Золотоустого" присвячена пошуку джерел духовної опіки над людиною, витоки яких автор бачить у християнському середньовіччі. Життя і творча спадщина Іоана Золотоустого – яскравий приклад пояснення сутності й визначення ціннісної природи душпастирювання крізь призму поняття священства.Статья Светланы Билоус "Аксиологические измерения душпастирства в произведениях Іоана Золотоустого" посвящена поиску источников духовной опеки над человеком, истоки которіх автор видит в христианском средневековье. Жизнь и творческое наследство Иоанна Золотоустого – яркий пример объяснения сущности и определение ценностной природы душпастирства сквозь призму понятия священства.The article by Svitlana Bilous "Axiological dimensions of priesthood in the Ioan Zolotoustyi’s works" is dedicated to finding sources of spiritual care over a human, the origin of which the author sees in the Christian Middle Ages. The life and literary heredity of Ioan Zolotoustyi is a brilliant pattern of explaining the essence and definition of valuable ​​nature of pastoral care through the prism of the concept of the priesthood

Preoperative predictors for early and very early disease recurrence in patients undergoing resection of pancreatic ductal adenocarcinoma

BACKGROUND: This study aimed to identify predictors for early and very early disease recurrence in patients undergoing resection of pancreatic ductal adenocarcinoma (PDAC) resection with and without neoadjuvant therapy. METHODS: Included were patients who underwent PDAC resection (2014-2016). Multivariable multinomial regression was performed to identify preoperative predictors for manifestation of recurrence within 3, 6 and 12 months after PDAC resection. RESULTS: 836 patients with a median follow-up of 37 (interquartile range [IQR] 30-48) months and overall survival of 18 (IQR 10-32) months were analyzed. 670 patients (80%) developed recurrence: 82 patients (10%) <3 months, 96 patients (11%) within 3-6 months and 226 patients (27%) within 6-12 months. LogCA 19-9 (OR 1.25 [95% CI 1.10-1.41]; P < 0.001) and neoadjuvant treatment (OR 0.09 [95% CI 0.01-0.68]; P = 0.02) were associated with recurrence <3 months. LogCA 19-9 (OR 1.23 [95% CI 1.10-1.38]; P < 0.001) and 0-90° venous involvement on CT imaging (OR 2.93 [95% CI 1.60-5.37]; P < 0.001) were associated with recurrence within 3-6 months. A Charlson Age Comorbidity Index ≥4 (OR 1.53 [95% CI 1.09-2.16]; P = 0.02) and logCA 19-9 (OR 1.24 [95% CI 1.14-1.35]; P < 0.001) were related to recurrence within 6-12 months. CONCLUSION: This study demonstrates preoperative predictors that are associated with the manifestation of early and very early recurrence after PDAC resection. Knowledge of these predictors can be used to guide individualized surveillance and treatment strategies

Detection, Treatment, and Survival of Pancreatic Cancer Recurrence in the Netherlands A Nationwide Analysis

OBJECTIVE: To evaluate whether detection of recurrent pancreatic ductal adenocarcinoma (PDAC) in an early, asymptomatic stage increases the number of patients receiving additional treatment, subsequently improving survival. SUMMARY OF BACKGROUND DATA: International guidelines disagree on the value of standardized postoperative surveillance for early detection and treatment of PDAC recurrence. METHODS: A nationwide, observational cohort study was performed including all patients who underwent PDAC resection (2014-2016). Prospective baseline and perioperative data were retrieved from the Dutch Pancreatic Cancer Audit. Data on follow-up, treatment, and survival were collected retrospectively. Overall survival (OS) was evaluated using multivariable Cox regression analysis, before and after propensity-score matching, stratified for patients with symptomatic and asymptomatic recurrence. RESULTS: Eight hundred thirty-six patients with a median follow-up of 37 months (interquartile range 30-48) were analyzed. Of those, 670 patients (80%) developed PDAC recurrence after a median follow-up of 10 months (interquartile range 5-17). Additional treatment was performed in 159/511 patients (31%) with symptomatic recurrence versus 77/159 (48%) asymptomatic patients (P < 0.001). After propensity-score matching on lymph node ratio, adjuvant therapy, disease-free survival, and recurrence site, additional treatment was independently associated with improved OS for both symptomatic patients [hazard ratio 0.53 (95% confidence interval 0.42-0.67); P < 0.001] and asymptomatic patients [hazard ratio 0.45 (95% confidence interval 0.29-0.70); P < 0.001]. CONCLUSIONS: Additional treatment of PDAC recurrence was independently associated with improved OS, with asymptomatic patients having a higher probability to receive recurrence treatment. Therefore, standardized postoperative surveillance aiming to detect PDAC recurrence before the onset of symptoms has the potential to improve survival. This provides a rationale for prospective studies on standardized surveillance after PDAC resection

Treatment strategies and clinical outcomes in consecutive patients with locally advanced pancreatic cancer:A multicenter prospective cohort

Introduction: Since current studies on locally advanced pancreatic cancer (LAPC) mainly report from single, high-volume centers, it is unclear if outcomes can be translated to daily clinical practice. This study provides treatment strategies and clinical outcomes within a multicenter cohort of unselected patients with LAPC. Materials and methods: Consecutive patients with LAPC according to Dutch Pancreatic Cancer Group criteria, were prospectively included in 14 centers from April 2015 until December 2017. A centralized expert panel reviewed response according to RECIST v1.1 and potential surgical resectability. Primary outcome was median overall survival (mOS), stratified for primary treatment strategy. Results: Overall, 422 patients were included, of whom 77% (n = 326) received chemotherapy. The majority started with FOLFIRINOX (77%, 252/326) with a median of six cycles (IQR 4-10). Gemcitabine monotherapy was given to 13% (41/326) of patients and nab-paclitaxel/gemcitabine to 10% (33/326), with a median of two (IQR 3-5) and three (IQR 3-5) cycles respectively. The mOS of the entire cohort was 10 months (95%CI 9-11). In patients treated with FOLFIRINOX, gemcitabine monotherapy, or nab-paclitaxel/gemcitabine, mOS was 14 (95%CI 13-15), 9 (95%CI 8-10), and 9 months (95%CI 8-10), respectively. A resection was performed in 13% (32/252) of patients after FOLFIRINOX, resulting in a mOS of 23 months (95%CI 12-34). Conclusion: This multicenter unselected cohort of patients with LAPC resulted in a 14 month mOS and a 13% resection rate after FOLFIRINOX. These data put previous results in perspective, enable us to inform patients with more accurate survival numbers and will support decision-making in clinical practice. (C) 2020 The Authors. Published by Elsevier Ltd

Towards better fall prevention: Examining the interplay between factors that influence gait in older patients

Falling is a serious problem among older patients: it is the combination of a high fall incidence together with a high susceptibility to injuries that makes a relatively mild fall potentially dangerous to these old persons. Falling is a multifactorial problem, but postural instability during daily activities, such as walking, is suggested to be the most consistent predictor of falls. Age-related neurophysiological changes and a high prevalence of clinical diseases result in a slower and less coordinated gait in older patients. These changes in the gait pattern can be quantified by a wide variety of gait parameters, each characterizing different aspects of the gait pattern. Several studies among relatively young and healthy older adults have shown that gait characteristics, such as gait speed, stride-to-stride variability, gait asymmetry, harmonic ratios, and sample entropy, can differentiate fallers from non-fallers. However, these results of these studies cannot be extrapolated to older patients, since in these old patients there are, besides the normal age-related neurophysiological changes, additional comorbid factors present that might affect the walking pattern, and consequently increase fall risk. Therefore, in the present thesis, it was aimed to examine the association between several phenomena that occur common in geriatric patients, including osteoporosis-related factors (e.g., vertebral fractures, increased thoracic kyphosis, and a flexed posture; part I of this thesis), medication-use (e.g., fall-risk-increasing drugs, such as antidepressants, benzodiazepines and antiepileptics; part II), and frailty-related factors (e.g., muscle strength and weight loss; part III) with postural control during walking in older patients visiting a geriatric outpatient clinic. Based on the studies described in the first part of this thesis, it was concluded that patients with a flexed posture, an increased thoracic kyphosis, and/or prevalent vertebral fractures have an impaired postural control. This might be the underlying mechanism for the increased fall incidence that was found in patients with an increased thoracic kyphosis. The second part of this thesis described that postural control was impaired in healthy young and older adults when they used psychotropic drugs. These effects were not so clearly manifested in older patients, since frailty-related parameters in this population were stronger associated with impaired gait performance than the use of psychotropic medications. Since impairments in gait and balance are the main risk factors for falls, this emphasizes the need for a multifactorial approach in fall risk assessment, as described in the third part of this thesis, including gait analysis, medication review, and screening for frailty- and osteoporosis-related factors, in order to protect patients at risk for falling in an early stage and offer them an individualized intervention tailed to the identified fall risk factors

Towards better fall prevention : Examining the interplay between factors that influence gait in older patients

Falling is a serious problem among older patients: it is the combination of a high fall incidence together with a high susceptibility to injuries that makes a relatively mild fall potentially dangerous to these old persons. Falling is a multifactorial problem, but postural instability during daily activities, such as walking, is suggested to be the most consistent predictor of falls. Age-related neurophysiological changes and a high prevalence of clinical diseases result in a slower and less coordinated gait in older patients. These changes in the gait pattern can be quantified by a wide variety of gait parameters, each characterizing different aspects of the gait pattern. Several studies among relatively young and healthy older adults have shown that gait characteristics, such as gait speed, stride-to-stride variability, gait asymmetry, harmonic ratios, and sample entropy, can differentiate fallers from non-fallers. However, these results of these studies cannot be extrapolated to older patients, since in these old patients there are, besides the normal age-related neurophysiological changes, additional comorbid factors present that might affect the walking pattern, and consequently increase fall risk. Therefore, in the present thesis, it was aimed to examine the association between several phenomena that occur common in geriatric patients, including osteoporosis-related factors (e.g., vertebral fractures, increased thoracic kyphosis, and a flexed posture; part I of this thesis), medication-use (e.g., fall-risk-increasing drugs, such as antidepressants, benzodiazepines and antiepileptics; part II), and frailty-related factors (e.g., muscle strength and weight loss; part III) with postural control during walking in older patients visiting a geriatric outpatient clinic. Based on the studies described in the first part of this thesis, it was concluded that patients with a flexed posture, an increased thoracic kyphosis, and/or prevalent vertebral fractures have an impaired postural control. This might be the underlying mechanism for the increased fall incidence that was found in patients with an increased thoracic kyphosis. The second part of this thesis described that postural control was impaired in healthy young and older adults when they used psychotropic drugs. These effects were not so clearly manifested in older patients, since frailty-related parameters in this population were stronger associated with impaired gait performance than the use of psychotropic medications. Since impairments in gait and balance are the main risk factors for falls, this emphasizes the need for a multifactorial approach in fall risk assessment, as described in the third part of this thesis, including gait analysis, medication review, and screening for frailty- and osteoporosis-related factors, in order to protect patients at risk for falling in an early stage and offer them an individualized intervention tailed to the identified fall risk factors

P270: Factors associated with fall rate in psychogeriatric residents

Introduction: Falls in psychogeriatric residents represent a costly but unresolved safety issue. Identifying fall risk factors and their inter-relationship may help to individualize prevention programs and increase the effectiveness. Therefore, we aimed to examine the relationship between patient characteristics and fall rate in psychogeriatric residents. Methods: Twenty nursing home residents with dementia (80±11 years; 60% male) living on a psychogeriatric ward participated. Based on patient records, we identified 66 patient characteristics and extracted the number of falls over 19 months. Patient characteristics represented seven domains: demographics, ADL, mobility, cognition and behaviour, vision and hearing, medical conditions, and drug-use. We evaluated the relationship between patient characteristics and fall rate using multivariate Partial Least Squares regression. Results: A total of 115 falls (5.1±6.7 falls/person year) occurred during the study period. The 66 patient characteristics included in the model explained 96% of the variance in fall rate. Reduced mobility abilities, indicators of disinhibited behavior, diabetes, and use of analgesics, beta blocking agents and psycholeptics were positively associated with fall rate. Whereas immobility, heart failure, and the inability to communicate were negatively associated fall rate. Conclusion: Dementia is often indicated as fall risk factor; however, our results showed that especially cognitive impairment related to disinhibited behaviour was associated with a high fall rate in psychogeriatric residents. Furthermore, immobility and inactivity seemed to decrease fall rate. The analytic approach provided a detailed view of the fall risk factors and their interactions in psychogeriatric residents, enabling more effective fall prevention

L'abord de la sexualité des adultes en médecine générale (étude quantitative des pratiques et représentations de médecins généralistes hommes et femmes)

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