T/N ratios before, during and after AT-II infusion, and T/N ratio improvement factors in patients with hepatic malignancies.

<p>T/N ratios are described as median (range). P-values correspond to reported significance levels of Wilcoxon test for paired data. *The first p-value refers to the improvement of T/N ratio during infusion and the last to post-infusion. Abbreviations: NR = Not Reported.</p

Characteristics of studies on the effect of AT-II on the T/N ratio in patients with hepatic malignancies.

<p>Abbreviations: HCC = Hepatocellular Carcinoma. CRLM = Colorectal Liver Metastases. UP = Metastases of an Unknown Primary. PCLM = Pancreatic Cancer Liver Metastases. NA = Not Available. RA = radioactivity. SPECT = Single-Photon Emission Computed Tomography. HAPS = Hepatic Arterial Perfusion Scintigraphy. PET = Positron Emission Tomography. ^81mKr = Krypton-81m. ¹³¹I = Iodine-131. ^99mTc MSA = Radiolabeled albumin microspheres. ⁶²Cu-PTSM = copper-pyruvaldehyde-bis (N4-methylthiosemicarbazone).</p

Flowchart of study design.

<p>IIA = Internal Iliac Artery. CIA = Common Iliac Artery. EIA = External Iliac Artery.</p

Search Syntax.

<p>In this table, the search syntax used in PubMed, EMBASE and Cochrane databases is displayed. The number of results include double titles. In total, 524 original titles were identified.</p

Quality assessment of selected studies.

<p>Abbreviations: Y = Yes, N = No.</p

Treatment of a patient.

<p>(a) Digital subtraction angiography of the left common iliac artery showing a proximal stenosis of the internal iliac artery (IIA), with sub-optimal filling of subsequent branches. (b) Result after treatment with 5 and 6 mm percutaneous transluminal angioplasty, showing residual origin stenosis of the IIA of more than 30%. (c) Subsequent stent placement (Palmaz 6 mm diameter) reduced the stenosis grade to less than 30%, and provided adequate distal blood flow. (d) Overlay of Figure c showing branches of mentioned vessels, guide wire position (white dotted line) and placed stent (white mesh). CIA = Common Iliac Artery. EIA = External Iliac Artery. IIA = Internal Iliac Artery.</p

Treatment of a patient (#7) with bilateral buttock claudication and iliac stenoses.

<p>(a) Digital subtraction angiography showing the sheath retrogradely advanced to the common iliac artery. Stenoses of the external and internal iliac arteries are visible at their respective origins (arrows). (b) Results of percutaneous transluminal angioplasty of the external iliac artery with a 7 mm balloon and the internal iliac artery with a 4 mm balloon catheter. CIA = Common Iliac Artery. EIA = External Iliac Artery. IIA = Internal Iliac Artery.</p

Grade 3/4 laboratory toxicity.

<p>Values are presented as n (percentage).</p>*<p>This number includes four patients with a history of previous hemihepatectomy.</p

Kaplan-Meier Survival curve per tumor type.

<p>The blue line represents patients with colorectal liver metastases (CRLM), the green line represents patients with neuroendocrine tumor (NET) liver metastases, and the red line represents patients with liver metastases from other primary tumors.</p

Treatment details.

<p>Values are presented as n (percentage), median (range) or mean ± standard deviation. * This number includes four patients with a history of previous hemihepatectomy. Abbreviations: MBq = Megabecquerel; Gy = Gray; LHA = Left Hepatic Artery; RHA = Right Hepatic Artery; PHA = Proper Hepatic Artery; CHA = Common Hepatic Artery.</p