993 research outputs found
Modified Paschos-Wolfenstein relation and extraction of weak mixing angle sin^2 theta_W
The NuTeV collaboration reported anomalously large weak mixing angle sin^2
theta_W in comparison with the standard model prediction. Neutrino and
antineutrino charged- and neutral-current events are analyzed for extracting
sin^2 theta_W. Although the Paschos-Wolfenstein relation is not directly used
in the analysis, it plays an important role in the determination. Noting that
the target nucleus, iron, is not an isoscalar nucleus, we derive a
leading-order expression for a modified Paschos-Wolfenstein relation for
nuclei, which may have neutron excess. Then, using charge and baryon-number
conservations for nuclei, we discuss a nuclear correction in the sin^2 theta_W
determination. It is noteworthy that nuclear modifications are different
between valence up- and down-quark distributions. We show this difference
effect on the NuTeV sin^2 theta_W deviation.Comment: 5 pages, REVTeX4.0, revtex4.cls, url.sty, natbib.sty, revsymb.sty,
10pt.rtx, aps.rtx, amssymb.sty, amsfonts.sty, 3 eps figures. Phys. Rev. D in
press. Email: [email protected] See also http://hs.phys.saga-u.ac.j
Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors.
Mitogen-Activated Protein Kinases (MAPKs) control a wide array of cellular functions by transducing extracellular information into defined biological responses. In order to understand how these pathways are regulated, dynamic single cell measurements are highly needed. Fluorescence microscopy is well suited to perform these measurements. However, more dynamic and sensitive biosensors that allow the quantification of signaling activity in living mammalian cells are required. We have engineered a synthetic fluorescent substrate for human MAPKs (ERK, JNK and p38) that relocates from the nucleus to the cytoplasm when phosphorylated by the kinases. We demonstrate that this reporter displays an improved response compared to other relocation biosensors. This assay allows to monitor the heterogeneity in the MAPK response in a population of isogenic cells, revealing pulses of ERK activity upon a physiological EGFR stimulation. We show applicability of this approach to the analysis of multiple cancer cell lines and primary cells as well as its application in vivo to developing tumors. Using this ERK biosensor, dynamic single cell measurements with high temporal resolution can be obtained. These MAPK reporters can be widely applied to the analysis of molecular mechanisms of MAPK signaling in healthy and diseased state, in cell culture assays or in vivo
The CDF dijet excess from intrinsic quarks
The CDF collaboration reported an excess in the production of two jets in
association with a . We discuss constraints on possible new particle state
interpretations of this excess. The fact of no statistically significant
deviation from the SM expectation for {+dijet} events in CDF data disfavors
the new particle explanation. We show that the nucleon intrinsic strange quarks
provide an important contribution to the boson production in association
with a single top quark production. Such {+t} single top quark production
can contribute to the CDF {+dijet} excess, thus the nucleon intrinsic quarks
can provide a possible explanation to the CDF excess in {+dijet} but not in
{+dijet} events.Comment: 4 latex pages, 1 figure. Version for journal publicatio
Pion-photon and photon-pion transition form factors in light-cone formalism
We derive the minimal Fock-state expansions of the pion and the photon wave
functions in light-cone formalism, then we calculate the pion-photon and the
photon-pion transition form factors of and
processes by employing these
quark-antiquark wave functions of the pion and the photon. We find that our
calculation for the transition form factor
agrees with the experimental data at low and moderately high energy scale.
Moreover, the physical differences and inherent connections between the
transition form factors of and have been illustrated, which indicate that these
two physical processes are intrinsically related. In addition, we also discuss
the form factor and the decay width at .Comment: 20 pages, 2 figure
The Proton Spin and the Wigner Rotation
It is shown that in both the gluonic and strange sea explanations of the
Ellis-Jaffe sum rule violation discovered by the European Muon Collaboration
(EMC), the spin of the proton, when viewed in in its rest reference frame,
could by fully provided by quarks and antiquarks within a simple quark model
picture, taken into account the relativistic effect from the Wigner rotation.Comment: 13 latex page
Anomalous Neutrino Interaction, Muon g-2, and Atomic Parity Nonconservation
We propose a simple unified description of two recent precision measurements
which suggest new physics beyond the Standard Model of particle interactions,
i.e. the deviation of in deep inelastic neutrino-nucleon
scattering and that of the anomalous magnetic moment of the muon. Our proposal
is also consistent with a third precision measurement, i.e. that of parity
nonconservation in atomic Cesium, which agrees with the Standard Model.Comment: 9 pages, including 1 figure, latest muon g-2 information adde
Resonant inelastic x-ray scattering (RIXS) spectra of magnesium diboride
Using the tight-binding linear muffin-tin orbitals method, the soft x-ray
fluorescence K-emission spectra of boron in MgB_2, excited close to the
absorption edge, are estimated. In the calculations the angle of incidence
between the direction of the incoming photon and the hexagonal axis of the
specimen is 60 degrees and 75 degrees. Comparison with experiment is possible
in the former case where good agreement is found. Furthermore, another resonant
feature below the Fermi energy is predicted for the larger angle. This feature
can be related to the excitations to the antibonding B pi-band in the
neighbourhood of the L-H line in the Brillouin zone.Comment: 4 pages with 4 figure
New insights into the role of DNA synthesis in meiotic recombination
Meiosis comprises two rounds of nuclear division following a single phase of DNA replication, leading to the production of haploid gametes and is essential for sexual reproduction in eukaryotes. Unlike mitosis, meiosis involves homologous chromosome pairing, synapsis, and recombination during prophase I. Meiotic recombination not only ensures the accurate segregation of homologs, but also redistributes alleles among offspring. DNA synthesis is a critical process during meiotic recombination, but our understanding of the proteins that execute and regulate it is limited. This review summarizes the recent advances in defining the role of DNA synthesis in meiotic recombination through analyses of DNA synthesis genes, with specific emphasis on DNA polymerases (e.g., Polε and Polδ), replication processivity factor RFC1 and translesion polymerases (e.g., Polζ). We also present a new double strand break repair model for meiotic recombination, which includes lagging strand DNA synthesis and leading strand elongation. Finally, we propose that DNA synthesis is one of critical factors for discriminating meiotic recombination pathways and that this differentiation may be conserved among eukaryotes
The influence of direct -meson production to the determination on the nucleon strangeness asymmetry via dimuon events in neutrino experiments
Experimentally, the production of oppositely charged dimuon events by
neutrino and anti-neutrino deep inelastic scattering (DIS) is used to determine
the strangeness asymmetry inside a nucleon. Here we point out that the direct
production of -meson in DIS may make substantial influence to the
measurement of nucleon strange distributions. The direct -meson production
is via the heavy quark recombination (HQR) and via the light quark
fragmentation from perturbative QCD (LQF-P). To see the influence precisely, we
compute the direct -meson productions via HQR and LQF-P quantitatively and
estimate their corrections to the analysis of the strangeness asymmetry. The
results show that HQR has stronger effect than LQF-P does, and the former may
influence the experimental determination of the nucleon strangeness asymmetry.Comment: 9 latex pages, 7 figure
The NuTeV Anomaly, Neutrino Mixing, and a Heavy Higgs Boson
Recent results from the NuTeV experiment at Fermilab and the deviation of the
Z invisible width, measured at LEP/SLC, from its Standard Model (SM) prediction
suggest the suppression of neutrino-Z couplings. Such suppressions occur
naturally in models which mix the neutrinos with heavy gauge singlet states. We
postulate a universal suppression of the Z-nu-nu couplings by a factor of
(1-epsilon) and perform a fit to the Z-pole and NuTeV observables with epsilon
and the oblique correction parameters S and T. Compared to a fit with S and T
only, inclusion of epsilon leads to a dramatic improvement in the quality of
the fit. The values of S and T preferred by the fit can be obtained within the
SM by a simple increase in the Higgs boson mass. However, if the W mass is also
included in the fit, a non-zero U parameter becomes necessary which cannot be
supplied within the SM. The preferred value of epsilon suggests that the seesaw
mechanism may not be the reason why neutrinos are so light.Comment: 19 pages, REVTeX4, 8 postscript figures. Updated references. Typos
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