269,609 research outputs found
Reexamining the "finite-size" effects in isobaric yield ratios using a statistical abrasion-ablation model
The "finite-size" effects in the isobaric yield ratio (IYR), which are shown
in the standard grand-canonical and canonical statistical ensembles (SGC/CSE)
method, is claimed to prevent obtaining the actual values of physical
parameters. The conclusion of SGC/CSE maybe questionable for neutron-rich
nucleus induced reaction. To investigate whether the IYR has "finite-size"
effects, the IYR for the mirror nuclei [IYR(m)] are reexamined using a modified
statistical abrasion-ablation (SAA) model. It is found when the projectile is
not so neutron-rich, the IYR(m) depends on the isospin of projectile, but the
size dependence can not be excluded. In reactions induced by the very
neutron-rich projectiles, contrary results to those of the SGC/CSE models are
obtained, i.e., the dependence of the IYR(m) on the size and the isospin of the
projectile is weakened and disappears both in the SAA and the experimental
results.Comment: 5 pages and 4 figure
Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity
Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation. The maintenance of chromatin domain integrity can require the setting of boundaries. The HS4 insulator element marks the 3′ boundary of a heterochromatin region located upstream of the chicken β-globin gene cluster. Here we show that HS4 recruits the E3 ligase RNF20/BRE1A to mediate H2B mono-ubiquitination (H2Bub1) at this insulator. Knockdown experiments show that RNF20 is required for H2Bub1 and processive H3K4 methylation. Depletion of RNF20 results in a collapse of the active histone modification signature at the HS4 chromatin boundary, where H2Bub1, H3K4 methylation, and hyperacetylation of H3, H4, and H2A.Z are rapidly lost. A remarkably similar set of events occurs at the HSA/HSB regulatory elements of the FOLR1 gene, which mark the 5′ boundary of the same heterochromatin region. We find that persistent H2Bub1 at the HSA/HSB and HS4 elements is required for chromatin boundary integrity. The loss of boundary function leads to the sequential spreading of H3K9me2, H3K9me3, and H4K20me3 over the entire 50 kb FOLR1 and β-globin region and silencing of FOLR1 expression. These findings show that the HSA/HSB and HS4 boundary elements direct a cascade of active histone modifications that defend the FOLR1 and β-globin gene loci from the pervasive encroachment of an adjacent heterochromatin domain. We propose that many gene loci employ H2Bub1-dependent boundaries to prevent heterochromatin spreading
Numerical framework for transcritical real-fluid reacting flow simulations using the flamelet progress variable approach
An extension to the classical FPV model is developed for transcritical
real-fluid combustion simulations in the context of finite volume, fully
compressible, explicit solvers. A double-flux model is developed for
transcritical flows to eliminate the spurious pressure oscillations. A hybrid
scheme with entropy-stable flux correction is formulated to robustly represent
large density ratios. The thermodynamics for ideal-gas values is modeled by a
linearized specific heat ratio model. Parameters needed for the cubic EoS are
pre-tabulated for the evaluation of departure functions and a quadratic
expression is used to recover the attraction parameter. The novelty of the
proposed approach lies in the ability to account for pressure and temperature
variations from the baseline table. Cryogenic LOX/GH2 mixing and reacting cases
are performed to demonstrate the capability of the proposed approach in
multidimensional simulations. The proposed combustion model and numerical
schemes are directly applicable for LES simulations of real applications under
transcritical conditions.Comment: 55th AIAA Aerospace Sciences Meeting, Dallas, T
Digital numerically controlled oscillator
The frequency and phase of an output signal from an oscillator circuit are controlled with accuracy by a digital input word. Positive and negative alterations in output frequency are both provided for by translating all values of input words so that they are positive. The oscillator reference frequency is corrected only in one direction, by adding phase to the output frequency of the oscillator. The input control word is translated to a single algebraic sign and the digital 1 is added thereto. The translated input control word is then accumulated. A reference clock signal having a frequency at an integer multiple of the desired frequency of the output signal is generated. The accumulated control word is then compared with a threshold level. The output signal is adjusted in a single direction by dividing the frequency of the reference clock signal by a first integer or by an integer different from the first integer
Arbitrarily Large Continuous-Variable Cluster States from a Single Quantum Nondemolition Gate
We present a compact experimental design for producing an arbitrarily large
optical continuous-variable cluster state using just one single-mode vacuum
squeezer and one quantum nondemolition gate. Generating the cluster state and
computing with it happen simultaneously: more entangled modes become available
as previous modes are measured, thereby making finite the requirements for
coherence and stability even as the computation length increases indefinitely.Comment: (v2) 5 pages, 4 color figures, added brief mention of fault
tolerance, version accepted for publication (note: actual published version
is edited slightly for space); (v1) 4 pages, 4 color figure
Dynamics of ligand substitution in labile cobalt complexes resolved by ultrafast T-jump
Ligand exchange of hydrated metal complexes is common in chemical and biological systems. Using the ultrafast T-jump, we examined this process, specifically the transformation of aqua cobalt (II) complexes to their fully halogenated species. The results reveal a stepwise mechanism with time scales varying from hundreds of picoseconds to nanoseconds. The dynamics are significantly faster when the structure is retained but becomes rate-limited when the octahedral-to-tetrahedral structural change bottlenecks the transformation. Evidence is presented, from bimolecular kinetics and energetics (enthalpic and entropic), for a reaction in which the ligand assists the displacement of water molecules, with the retention of the entering ligand in the activated state. The reaction time scale deviates by one to two orders of magnitude from that of ionic diffusion, suggesting the involvement of a collisional barrier between the ion and the much larger complex
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