Implementing Path of Zhengzhou University\u27s Establishment of Football Academy

Under the new policy background of the 2020 Opinions on Deepening the Integration of Sports and Education and Promoting the Healthy Development of Adolescents , as the highest educational institution in China, higher education institutions should shoulder the responsibility of cultivating high-quality talents to meet social needs. As the highest-quality higher education institution in Henan Province, Zhengzhou University\u27s innovation and exploration of teaching methods and talent training models under the background of the integration of sports and education will play a leading role in the development of higher education in Henan Province. Through combing and analyzing the existing policy documents, firstly, explore the reasons, significance, and social background of the construction of the football academy; secondly, analyze the theoretical basis for the construction of the football academy in the context of relevant policies, and analyze the demand for talent training required by the policy. It was combining with the construction situation of my country’s football academy at this stage, implementing the specific requirements of the integration strategy of sports and education, establishing the guiding ideology of “diversified integration” after establishing the academy from the three levels of discipline establishment, talent training, and talent transfer. Investigate the needs of the talent market at the stage, determine the direction of talent training, and discuss how to set up specific majors for domestic enrollment after the establishment of the college. Based on this, it proposes the professional setting direction and specific curriculum arrangement and assessment methods for talent training from five aspects: education and teaching, sports competitions, sports medicine, sports media, economics, and management. Finally, it discusses the difficulties faced by students, teachers, and employment development after graduation in the process of football academy construction and how to use existing resources and related policy support to solve the difficulties. As an innovative way of running a school, the Football Academy provides new opportunities for the reform and innovation of sports talent cultivation. In the torrent of sports and education integration reform, make full use of existing resources, integrate and mobilize various high-quality resources in the region, and finally transform them into the winning resources for the new development of our school\u27s sports discipline in this innovative school-running method. After the football academy is established, it will become a link between campus football and professional football in the province, and a breeding base for national high-quality football industry talents. It will also provide a strong impetus for the development of football in my country

An Analysis of the Construction and Development of ‘Starry Star’ Training Camp in Zhengzhou City

Since 2017, the Ministry of Education has taken the lead in establishing the \u27Starry Star\u27 pilot training camp. As a leading city of school football campaign/activity, Zhengzhou City takes up heavy responsibility of continuously promoting the rapid development of school football in Henan Province. This paper adopts such methodologies such as literature, fieldwork, mathematical statistics and logical analysis to identify the weaknesses in the current phase of construction and to make reasonable recommendations according to policies and the actual situation for pointing out the direction for the future development. In terms of organizational leadership, all relevant policies and documents are well-developed reflecting the high degree of importance attached to each training camp, but very few of them have omissions in the development of the system of admissions and training management regulations. In terms of condition guarantee, three aspects are prominent, including the treatment of coaches (calculation of hours), the size of the training grounds at each training site not meeting the requirements of the camps\u27 participation groups (due to limited size of the campus), and the lack of implementation of supporting funds (in the surrounding counties). In terms of competition and training, all schools lost points to varying degrees in the various detailed assessment indicators of the survey and assessment such as inappropriate teaching attitude of the teaching staff, unsystematic training syllabus, unfinished work arrangements for two tournaments and one practice and insufficient attention to the campers\u27 performance in cultural subjects. In terms of reserve training and training participation rate, nearly 30% of the camps failed to send outstanding athletes to higher level schools; half of the camps failed to ensure over 90% attendance of campers. It is suggested that relevant authorities should in future give standardized and clear policies regarding admissions and other related systems. Further, the authorities should clarify the way of coaches\u27 salary and title appraisal, focus on the implementation of matching funds for training camps, and gradually adjust the correspondence between matching camper groups and camp site conditions. As the main task of the Starry Star training camps, more attention should be placed in future work, improving policies, seriously correcting and dealing with various situations that affect the quality of race training in each camp. The authorities should optimize the way of supplying outstanding athletes, and at the same time strengthen regular inspections and random checks for the attendance, putting equal emphasis on training quality and participation

Cost-effective On-device Continual Learning over Memory Hierarchy with Miro

Continual learning (CL) trains NN models incrementally from a continuous stream of tasks. To remember previously learned knowledge, prior studies store old samples over a memory hierarchy and replay them when new tasks arrive. Edge devices that adopt CL to preserve data privacy are typically energy-sensitive and thus require high model accuracy while not compromising energy efficiency, i.e., cost-effectiveness. Our work is the first to explore the design space of hierarchical memory replay-based CL to gain insights into achieving cost-effectiveness on edge devices. We present Miro, a novel system runtime that carefully integrates our insights into the CL framework by enabling it to dynamically configure the CL system based on resource states for the best cost-effectiveness. To reach this goal, Miro also performs online profiling on parameters with clear accuracy-energy trade-offs and adapts to optimal values with low overhead. Extensive evaluations show that Miro significantly outperforms baseline systems we build for comparison, consistently achieving higher cost-effectiveness.Comment: This paper is to be published in the 29th Annual International Conference on Mobile Computing and Networking (ACM MobiCom 23

Adult Learners: A Targeted Marketing Approach

The development of the Adult Learner Capstone Project started with a focus and need to learn more about affinity groups in the Worcester area in order to reach the potential adult learner demographic. Although some partnerships already existed, the Director of Marketing and Communications for Graduate Admissions, Tara Probeck, yearned to explore the potential partnerships and alternative uses of professional organizations to market to the current working professionals. From this idea, our capstone project was introduced in hopes of establishing a comprehensive and exhaustive list of potential organizational partnerships, specific for the School of Professional Studies

Global profiling of the proteome, phosphoproteome, and N-glycoproteome of protoscoleces and adult worms of Echinococcus granulosus

IntroductionCystic echinococcosis (CE) is a chronic zoonosis caused by infection with the metacestode of the Echinococcus granulosus. A unique characteristic of E. granulosus protoscolex (PSC) is their ability to develop bidirectionally into an adult worm in the definitive host or a secondary hydatid cyst in the intermediate host. Furthermore, cestodes have a complex life cycle involving different developmental stages; however, the mechanisms underlying this development remain unknown. Several studies have demonstrated that certain matrix proteins undergo posttranslational modifications (PTMs), including phosphorylation and glycosylation, which have important regulatory effects on their functional properties.MethodsSystematic analyses of the proteome, phosphorylated modified proteome, and glycosylated modified proteome of protoscoleces (PSCs) and adult worms were performed using a proteomic strategy. Data are available via ProteomeXchange with identifier PXD043166.ResultsIn total, 6,407 phosphorylation sites and 1757 proteins were quantified. Of these, 2032 phosphorylation sites and 770 proteins were upregulated, and 2,993 phosphorylation sites and 1,217 proteins were downregulated in adult worms compared to PSCs. A total of 612 N-glycosylation sites were identified in the 392 N-glycoproteins. Of these, 355 N-glycosylation sites and 212 N-glycoproteins were quantified. Of these, 90 N-glycosylation sites and 64 N-glycoproteins were upregulated, and 171 N-glycosylation sites and 126 N-glycoproteins were downregulated in adult worms compared to PSCs. GO enrichment analysis indicated that the differentially expressed phosphoproteins were mainly enriched in the regulation of oxidoreduction coenzyme metabolic processes, myelin sheath, and RNA helicase activity, whereas the differentially expressed N-glycoproteins were enriched in the cellular response to unfolded proteins, endoplasmic reticulum lumen, and nucleic acid binding. KEGG enrichment analysis indicated that the differently expressed phosphoproteins were mainly enriched in RNA transport, hypertrophic cardiomyopathy (HCM), glycolysis/gluconeogenesis, HIF-1 signaling pathway and pyruvate metabolism. Differentially expressed N-glycoproteins were enriched in the PI3K-Akt signaling pathway, ECM-receptor interactions, and protein processing in the endoplasmic reticulum.DiscussionTo our knowledge, this study is the first global phosphoproteomic and N-glycoproteomic analysis of E. granulosus, which provides valuable information on the expression characteristics of E. granulosus and provides a new perspective to elucidate the role of protein phosphorylation and N-glycosylation in the development of E. granulosus

Genome-wide analysis and expression of the aquaporin gene family in Avena sativa L.

BackgroundOat (Avena sativa L.) belongs to the early maturity grass subfamily of the Gramineae subfamily oats (Avena) and has excellent characteristics, such as tolerance to barrenness, salt, cold, and drought. Aquaporin (AQP) proteins belong to the major intrinsic protein (MIP) superfamily, are widely involved in plant growth and development, and play an important role in abiotic stress responses. To date, previous studies have not identified or analyzed the AsAQP gene family system, and functional studies of oat AQP genes in response to drought, cold, and salt stress have not been performed.MethodsIn this study, AQP genes (AsAQP) were identified from the oat genome, and various bioinformatics data on the AQP gene family, gene structure, gene replication, promoters and regulatory networks were analyzed. Quantitative real-time PCR technology was used to verify the expression patterns of the AQP gene family in different oat tissues under different abiotic stresses.ResultsIn this study, a total of 45 AQP genes (AsAQP) were identified from the oat reference genome. According to a phylogenetic analysis, 45 AsAQP were divided into 4 subfamilies (PIP, SIP, NIP, and TIP). Among the 45 AsAQP, 23 proteins had interactions, and among these, 5AG0000633.1 had the largest number of interacting proteins. The 20 AsAQP genes were expressed in all tissues, and their expression varied greatly among different tissues and organs. All 20 AsAQP genes responded to salt, drought and cold stress. The NIP subfamily 6Ag0000836.1 gene was significantly upregulated under different abiotic stresses and could be further verified as a key candidate gene.ConclusionThe findings of this study provide a comprehensive list of members and their sequence characteristics of the AsAQP protein family, laying a solid theoretical foundation for further functional analysis of AsAQP in oats. This research also offers valuable reference for the creation of stress-tolerant oat varieties through genetic engineering techniques

Current Progress in CAR-T Cell Therapy for Solid Tumors

Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. Recently two CAR-T cell based therapeutics, Kymriah (Tisagenlecleucel) and Yescarta (Axicabtagene ciloleucel) approved by US FDA (US Food and Drug Administration) are now used for treatment of B cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL) respectively in the US. Despite the progresses made in treating hematological malignancies, challenges still remain for use of CAR-T cell therapy to treat solid tumors. In this landscape, most studies have primarily focused on improving CAR-T cells and overcoming the unfavorable effects of tumor microenvironment on solid tumors. To further understand the current status and trend for developing CAR-T cell based therapies for various solid tumors, this review emphasizes on CAR-T techniques, current obstacles, and strategies for application, as well as necessary companion diagnostics for treatment of solid tumors with CAR-T cells

Development of Structure-Switching Aptamers for Kanamycin Detection Based on Fluorescence Resonance Energy Transfer

The structure-switching aptamers are designed for the simple and rapid detection of kanamycin based on the signal transduction principle of fluorescence resonance energy transfer (FRET). The structure switch is composed of kanamycin-binding aptamers and the complementary strands, respectively labeled with fluorophore and quencher, denoted as FDNA and QDNA. In the absence of kanamycin, FDNA and QDNA form the double helix structure through the complementary pairing of bases. The fluorophore and the quencher are brought into close proximity, which results in the fluorescence quenching because of the FRET mechanism. In the presence of kanamycin, the FDNA specifically bind to the target due to the high affinity of aptamers, and the QDNA are dissociated. The specific recognition between aptamers and kanamycin will obstruct the formation of structure switch and reduce the efficiency of FRET between FDNA and QDNA, thus leading to the fluorescence enhancement. Therefore, based on the structure-switching aptamers, a simple fluorescent assay for rapid detection of kanamycin was developed. Under optimal conditions, there was a good linear relationship between kanamycin concentration and the fluorescence signal recovery. The linear range of this method in milk samples was 100–600 nM with the detection limit of 13.52 nM (3σ), which is well below the maximum residue limit (MRL) of kanamycin in milk. This method shows excellent selectivity for kanamycin over the other common antibiotics. The structure-switching aptamers have been successfully applied to the detection of kanamycin spiked in milk samples with the satisfying recoveries between 101.3 and 109.1%, which is well-consistent with the results from LC-MS/MS. Due to the outstanding advantages of facile operation, rapid detection, high sensitivity, excellent specificity, and low cost, the application and extension of this strategy for rapid determination of antibiotics in food samples may greatly improve the efficiency in food safety and quality supervision