Vascular device interaction with the endothelium

Copyright @ 2008 Elsevier. This is the post-print version of the article.Cerebral stents and Intra Aortic Balloon Pumps (IABP) are examples of mechanical devices that are inserted into arteries to restore flows to clinically healthy states. The stent and the IABP ‘correct’ the arterial flow by static dilation and by cyclical occlusion respectively. As this presentation shows, these functions are effectively modelled by current engineering practice. As interventions however, by their very nature they involve physical contact between a non-biological structure and the sensitive endothelial surface. The possible damage to the endothelium is not currently well addressed and we also consider this issue. Cerebral stents generally have two primary clinical objectives: to mechanically dilate a stenosed artery and to have minimal detrimental impact upon local blood flow characteristics. These objectives are well served at the arterial scale as these devices are evidently effective in opening up diseased arteries and restoring vital flows. However, at the near-wall micro-scale the picture is less satisfactory, as thin stent wires apply stresses to the endothelium and glycocalyx and the local flow is disturbed rather than being ideally streamlined. This causes further interaction with this endothelium topography. Wall Shear Stress (WSS) is the measure commonly used to indicate the interaction between fluid and wall but it is a broad brush approach that loses fidelity close to the wall. We will present simulation results of blood flow through a stented cerebral saccular aneurysm under these limitations of WSS. The Intra Aortic Balloon Pump (IABP) is a widely used temporary cardiac assist device. The balloon is usually inserted from the iliac artery, advanced in the aorta until it reaches the desired position; with its base just above the renal bifurcation and the tip approximately 10cm away from the aortic valve. The balloon is inflated and deflated every- (1:1), every other- (1:2) or every second (1:3) cardiac cycle. Balloon inflation, which takes place during early diastole, causes an increase in the pressure of the aortic root which leads to an increase in coronary flow. Balloon deflation which takes place during late diastole achieves one of the main IABP therapeutic effects by reducing left ventricular afterload. Unavoidably, the balloon contacts the inner wall of the aorta with every inflation/deflation cycle. This repeated event and possible contact with atherosclerotic plaque have been reported to be responsible for balloon rupture. However, there has not been a methodical study to investigate the mechanical effects of balloon-wall interaction. For example, during inflation the balloon approaches the endothelium as it displaces a volume of blood proximally and distally. This squeezing process generates shear stresses, which hasn't yet been quantified. Similarly, when the balloon moves away from the endothelium during deflation, it generates micro pressure differences that may impose stretching (pulling) stresses on the endothelium cells. Both of the above cases indicate that a very high spatial resolution is required in order to fully understand the process of interaction between device and endothelium, and to interpret the effects at the cellular level

Beyond the virtual intracranial stenting challenge 2007: non-Newtonian and flow pulsatility effects

The attached article is a post print version of the final published version which may be accessed at the link below. Crown Copyright (c) 2010 Published by Elsevier Ltd. All rights reserved.The Virtual Intracranial Stenting Challenge 2007 (VISC’07) is becoming a standard test case in computational minimally invasive cerebrovascular intervention. Following views expressed in the literature and consistent with the recommendations of a report, the effects of non-Newtonian viscosity and pulsatile flow are reported. Three models of stented cerebral aneurysms, originating from VISC’07 are meshed and the flow characteristics simulated using commercial computational fluid dynamics (CFD) software. We conclude that non-Newtonian and pulsatile effects are important to include in order to discriminate more effectively between stent designs

Finite SU(3)^3 model

We consider N=1 supersymmetric gauge theories based on the group SU(N)_1 x SU(N)_2 x ... x SU(N)_k with matter content (N,N*,1,...,1) + (1,N,N*,..., 1) + >... + (N*,1,1,...,N) as candidates for the unification symmetry of all particles. In particular we examine to which extent such theories can become finite, and find that a necessary condition is that there should be exactly three families. From phenomenological considerations an SU(3)^3 model is singled out. We consider an all-loop and a two-loop finite model based on this gauge group and we study their predictions concerning the third generation quark masses.Comment: 4 pages, 2 figures. Talk given at 17th International Conference on Supersymmetry and the Unification of Fundamental Interactions (SUSY09), Boston, USA, 5-10 June 200

Can a 3+2 Oscillation Model Explain the NuTeV Electroweak Results?

The weak mixing angle result from NuTeV falls three standard deviations above the value determined by global electroweak fits. It has been suggested that one possible explanation for this result could be the oscillation of electron neutrinos in the NuTeV beam to sterile neutrinos. This article examines several cases of masses and mixings for 3+2 neutrino oscillation models which fit the current oscillation data at 99% CL. We conclude that electron to sterile neutrino oscillations can account for only up to a third of a standard deviation between the NuTeV determination of the weak mixing angle and the standard model.Comment: 3 pages, 2 figures, submitted to Brief Report

Government Guarantees in Infrastructure Projects: A Second, Third Look at the Policy

To encourage private sector participation in public infrastructure projects, government guarantee has been utilized as an instrument to mitigate the risks associated with public investments. However, this creates contingent liabilities that the government has to face. This issue argues that the government must move towards project financing structures having less provision for subsidies and guarantees. Private sector should then have greater risk participation while strict monitoring measures should be implemented concerning contingent liabilities.government guarantee, public infrastructure projects, BOT scheme, private sector participation, contingent liability

A New Vision and Credit Policy Framework for Financing LGUs Basic Services and Development Projects

This paper presents a new vision and the proposed policy framework for financing local government’s basic services and development projects. This vision intends to wean away the LGUs from their dependence on the national government and to promote a more effective private sector participation in developing and funding local projects. The credit policy framework aims to direct and make LGUs creditworthy to the private sources of capital.local government unit, capital markets, services sector, credit program

Probing CP-violating Higgs contributions in gamma-gamma -> f anti-f through fermion polarization

We discuss the use of fermion polarization for studying neutral Higgs bosons at a photon collider. To this aim we construct polarization asymmetries which can isolate the contribution of a Higgs boson $\phi$ in $\gamma\gamma\to f \bar f$, $f=\tau/t$, from that of the QED continuum. This can help in getting information on the $\gamma\gamma\phi$ coupling in case $\phi$ is a CP eigenstate. We also construct CP-violating asymmetries which can probe CP mixing in case $\phi$ has indeterminate CP. Furthermore, we take the MSSM with CP violation as an example to demonstrate the potential of these asymmetries in a numerical analysis. We find that these asymmetries are sensitive to the presence of a Higgs boson as well as its CP properties over a wide range of MSSM parameters. In particular, the method suggested can cover the region where a light Higgs boson may have been missed by LEP due to CP violation in the Higgs sector, and may be missed as well at the LHC.Comment: 14 pages, 14 figures, typeset in revtex4. Version which has appeared in Physical Review D; typos in two references correcte