Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo

Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of schizophrenia and angina respectively, inhibit Akt-pS473 phosphorylation and promote FOXO3 nuclear localization and activation in TNBC cells. BPD and TFP inhibit survival and proliferation in TNBC cells and suppress the growth of TNBC tumors, whereas silencing FOXO3 reduces the BPD- and TFP-mediated suppression of survival in TNBC cells. While BPD and TFP decrease the expression of oncogenic c-Myc, KLF5, and dopamine receptor DRD2 in TNBC cells, silencing FOXO3 diminishes BPD- and TFP-mediated repression of the expression of these proteins in TNBC cells. Since c-Myc, KLF5, and DRD2 have been suggested to increase cancer stem cell-like populations in various tumors, reducing these proteins in response to BPD and TFP suggests a novel FOXO3-dependent mechanism underlying BPD- and TFP-induced apoptosis in TNBC cells

Numerical framework for transcritical real-fluid reacting flow simulations using the flamelet progress variable approach

An extension to the classical FPV model is developed for transcritical real-fluid combustion simulations in the context of finite volume, fully compressible, explicit solvers. A double-flux model is developed for transcritical flows to eliminate the spurious pressure oscillations. A hybrid scheme with entropy-stable flux correction is formulated to robustly represent large density ratios. The thermodynamics for ideal-gas values is modeled by a linearized specific heat ratio model. Parameters needed for the cubic EoS are pre-tabulated for the evaluation of departure functions and a quadratic expression is used to recover the attraction parameter. The novelty of the proposed approach lies in the ability to account for pressure and temperature variations from the baseline table. Cryogenic LOX/GH2 mixing and reacting cases are performed to demonstrate the capability of the proposed approach in multidimensional simulations. The proposed combustion model and numerical schemes are directly applicable for LES simulations of real applications under transcritical conditions.Comment: 55th AIAA Aerospace Sciences Meeting, Dallas, T

Axial vector form factor of nucleons in a light-cone diquark model

The nucleon axial vector form factor is investigated in a light-cone quark spectator diquark model, in which Melosh rotations are applied to both the quark and vector diquark. It is found that this model gives a very good description of available experimental data and the results have very little dependence on the parameters of the model. The relation between the nucleon axial constant and the anomalous magnetic moment of nucleons is also discussed.Comment: 8 pages, Revtex4, 1 figure, version to be published in Phys. Rev.

Pion-photon and photon-pion transition form factors in light-cone formalism

We derive the minimal Fock-state expansions of the pion and the photon wave functions in light-cone formalism, then we calculate the pion-photon and the photon-pion transition form factors of $\gamma ^{\ast}\pi ^{0}\to \gamma$ and $\gamma ^{\ast}\gamma \to \pi ^{0}$ processes by employing these quark-antiquark wave functions of the pion and the photon. We find that our calculation for the $\gamma ^{\ast}\gamma \to \pi ^{0}$ transition form factor agrees with the experimental data at low and moderately high energy scale. Moreover, the physical differences and inherent connections between the transition form factors of $\gamma ^{\ast}\pi ^{0}\to \gamma$ and $\gamma ^{\ast}\gamma \to \pi ^{0}$ have been illustrated, which indicate that these two physical processes are intrinsically related. In addition, we also discuss the $\pi ^{0}\to \gamma \gamma$ form factor and the decay width $\mathit{\Gamma}(\pi \to \gamma \gamma)$ at $Q^{2}=0$.Comment: 20 pages, 2 figure

Higgs bosons near 125 GeV in the NMSSM with constraints at the GUT scale

We study the NMSSM with universal Susy breaking terms (besides the Higgs sector) at the GUT scale. Within this constrained parameter space, it is not difficult to find a Higgs boson with a mass of about 125 GeV and an enhanced cross section in the diphoton channel. An additional lighter Higgs boson with reduced couplings and a mass <123 GeV is potentially observable at the LHC. The NMSSM-specific Yukawa couplings lambda and kappa are relatively large and tan(beta) is small, such that lambda, kappa and the top Yukawa coupling are of order 1 at the GUT scale. The lightest stop can be as light as 105 GeV, and the fine-tuning is modest. WMAP constraints can be satisfied by a dominantly higgsino-like LSP with substantial bino, wino and singlino admixtures and a mass of ~60-90 GeV, which would potentially be detectable by XENON100.Comment: 20 pages, 14 figure

Heavy quarkonium 2S states in light-front quark model

We study the charmonium 2S states $\psi'$ and $\eta_c'$, and the bottomonium 2S states $\Upsilon'$ and $\eta_b'$, using the light-front quark model and the 2S state wave function of harmonic oscillator as the approximation of the 2S quarkonium wave function. The decay constants, transition form factors and masses of these mesons are calculated and compared with experimental data. Predictions of quantities such as Br$(\psi' \to \gamma \eta_c')$ are made. The 2S wave function may help us learn more about the structure of these heavy quarkonia.Comment: 5 latex pages, final version for journal publicatio