10,735 research outputs found
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo
Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of schizophrenia and angina respectively, inhibit Akt-pS473 phosphorylation and promote FOXO3 nuclear localization and activation in TNBC cells. BPD and TFP inhibit survival and proliferation in TNBC cells and suppress the growth of TNBC tumors, whereas silencing FOXO3 reduces the BPD- and TFP-mediated suppression of survival in TNBC cells. While BPD and TFP decrease the expression of oncogenic c-Myc, KLF5, and dopamine receptor DRD2 in TNBC cells, silencing FOXO3 diminishes BPD- and TFP-mediated repression of the expression of these proteins in TNBC cells. Since c-Myc, KLF5, and DRD2 have been suggested to increase cancer stem cell-like populations in various tumors, reducing these proteins in response to BPD and TFP suggests a novel FOXO3-dependent mechanism underlying BPD- and TFP-induced apoptosis in TNBC cells
Numerical framework for transcritical real-fluid reacting flow simulations using the flamelet progress variable approach
An extension to the classical FPV model is developed for transcritical
real-fluid combustion simulations in the context of finite volume, fully
compressible, explicit solvers. A double-flux model is developed for
transcritical flows to eliminate the spurious pressure oscillations. A hybrid
scheme with entropy-stable flux correction is formulated to robustly represent
large density ratios. The thermodynamics for ideal-gas values is modeled by a
linearized specific heat ratio model. Parameters needed for the cubic EoS are
pre-tabulated for the evaluation of departure functions and a quadratic
expression is used to recover the attraction parameter. The novelty of the
proposed approach lies in the ability to account for pressure and temperature
variations from the baseline table. Cryogenic LOX/GH2 mixing and reacting cases
are performed to demonstrate the capability of the proposed approach in
multidimensional simulations. The proposed combustion model and numerical
schemes are directly applicable for LES simulations of real applications under
transcritical conditions.Comment: 55th AIAA Aerospace Sciences Meeting, Dallas, T
Axial vector form factor of nucleons in a light-cone diquark model
The nucleon axial vector form factor is investigated in a light-cone quark
spectator diquark model, in which Melosh rotations are applied to both the
quark and vector diquark. It is found that this model gives a very good
description of available experimental data and the results have very little
dependence on the parameters of the model. The relation between the nucleon
axial constant and the anomalous magnetic moment of nucleons is also discussed.Comment: 8 pages, Revtex4, 1 figure, version to be published in Phys. Rev.
Pion-photon and photon-pion transition form factors in light-cone formalism
We derive the minimal Fock-state expansions of the pion and the photon wave
functions in light-cone formalism, then we calculate the pion-photon and the
photon-pion transition form factors of and
processes by employing these
quark-antiquark wave functions of the pion and the photon. We find that our
calculation for the transition form factor
agrees with the experimental data at low and moderately high energy scale.
Moreover, the physical differences and inherent connections between the
transition form factors of and have been illustrated, which indicate that these
two physical processes are intrinsically related. In addition, we also discuss
the form factor and the decay width at .Comment: 20 pages, 2 figure
Higgs bosons near 125 GeV in the NMSSM with constraints at the GUT scale
We study the NMSSM with universal Susy breaking terms (besides the Higgs
sector) at the GUT scale. Within this constrained parameter space, it is not
difficult to find a Higgs boson with a mass of about 125 GeV and an enhanced
cross section in the diphoton channel. An additional lighter Higgs boson with
reduced couplings and a mass <123 GeV is potentially observable at the LHC. The
NMSSM-specific Yukawa couplings lambda and kappa are relatively large and
tan(beta) is small, such that lambda, kappa and the top Yukawa coupling are of
order 1 at the GUT scale. The lightest stop can be as light as 105 GeV, and the
fine-tuning is modest. WMAP constraints can be satisfied by a dominantly
higgsino-like LSP with substantial bino, wino and singlino admixtures and a
mass of ~60-90 GeV, which would potentially be detectable by XENON100.Comment: 20 pages, 14 figure
Heavy quarkonium 2S states in light-front quark model
We study the charmonium 2S states and , and the bottomonium
2S states and , using the light-front quark model and the
2S state wave function of harmonic oscillator as the approximation of the 2S
quarkonium wave function. The decay constants, transition form factors and
masses of these mesons are calculated and compared with experimental data.
Predictions of quantities such as Br are made. The
2S wave function may help us learn more about the structure of these heavy
quarkonia.Comment: 5 latex pages, final version for journal publicatio
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