899 research outputs found
A rigorous evaluation of crossover and mutation in genetic programming
The role of crossover and mutation in Genetic Programming (GP) has been the subject of much debate since the emergence of the field. In this paper, we contribute new empirical evidence to this argument using a rigorous and principled experimental method applied to six problems common in the GP literature. The approach tunes the algorithm parameters to enable a fair and objective comparison of two different GP algorithms, the first using a combination of crossover and reproduction, and secondly using a combination of mutation and reproduction. We find that crossover does not significantly outperform mutation on most of the problems examined. In addition, we demonstrate that the use of a straightforward Design of Experiments methodology is effective at tuning GP algorithm parameters
Nuclear accessibility of β-actin mRNA is measured by 3D single-molecule real-time tracking
Imaging single proteins or RNAs allows direct visualization of the inner workings of the cell. Typically, three-dimensional (3D) images are acquired by sequentially capturing a series of 2D sections. The time required to step through the sample often impedes imaging of large numbers of rapidly moving molecules. Here we applied multifocus microscopy (MFM) to instantaneously capture 3D single-molecule real-time images in live cells, visualizing cell nuclei at 10 volumes per second. We developed image analysis techniques to analyze messenger RNA (mRNA) diffusion in the entire volume of the nucleus. Combining MFM with precise registration between fluorescently labeled mRNA, nuclear pore complexes, and chromatin, we obtained globally optimal image alignment within 80-nm precision using transformation models. We show that {beta}-actin mRNAs freely access the entire nucleus and fewer than 60% of mRNAs are more than 0.5 {my}m away from a nuclear pore, and we do so for the first time accounting for spatial inhomogeneity of nuclear organization
On manifolds with nonhomogeneous factors
We present simple examples of finite-dimensional connected homogeneous spaces
(they are actually topological manifolds) with nonhomogeneous and nonrigid
factors. In particular, we give an elementary solution of an old problem in
general topology concerning homogeneous spaces
General Static Solutions of 2-dimensional Einstein-Dilaton-Maxwell-Scalar Theories
General static solutions of effectively 2-dimensional
Einstein-Dilaton-Maxwell-Scalar theories are obtained. Our model action
includes a class of 2-d dilaton gravity theories coupled with a gauge
field and a massless scalar field. Therefore it also describes the spherically
symmetric reduction of -dimensional Einstein-Scalar-Maxwell theories. The
properties of the analytic solutions are briefly discussed.Comment: 16 pages, Latex fil
Thermally assisted magnetization reversal in the presence of a spin-transfer torque
We propose a generalized stochastic Landau-Lifshitz equation and its
corresponding Fokker-Planck equation for the magnetization dynamics in the
presence of spin transfer torques. Since the spin transfer torque can pump a
magnetic energy into the magnetic system, the equilibrium temperature of the
magnetic system is ill-defined. We introduce an effective temperature based on
a stationary solution of the Fokker-Planck equation. In the limit of high
energy barriers, the law of thermal agitation is derived. We find that the
N\'{e}el-Brown relaxation formula remains valid as long as we replace the
temperature by an effective one that is linearly dependent of the spin torque.
We carry out the numerical integration of the stochastic Landau-Lifshitz
equation to support our theory. Our results agree with existing experimental
data.Comment: 5 figure
Magnetization dynamics with a spin-transfer torque
The magnetization reversal and dynamics of a spin valve pillar, whose lateral
size is 6464 nm, are studied by using micromagnetic simulation in
the presence of spin transfer torque. Spin torques display both characteristics
of magnetic damping (or anti-damping) and of an effective magnetic field. For a
steady-state current, both M-I and M-H hysteresis loops show unique features,
including multiple jumps, unusual plateaus and precessional states. These
states originate from the competition between the energy dissipation due to
Gilbert damping and the energy accumulation due to the spin torque supplied by
the spin current. The magnetic energy oscillates as a function of time even for
a steady-state current. For a pulsed current, the minimum width and amplitude
of the spin torque for achieving current-driven magnetization reversal are
quantitatively determined. The spin torque also shows very interesting thermal
activation that is fundamentally different from an ordinary damping effect.Comment: 15 figure
String Cosmology: A Review
We give an overview of the status of string cosmology. We explain the
motivation for the subject, outline the main problems, and assess some of the
proposed solutions. Our focus is on those aspects of cosmology that benefit
from the structure of an ultraviolet-complete theory.Comment: 55 pages. v2: references adde
Late-Time Tails of Wave Propagation in Higher Dimensional Spacetimes
We study the late-time tails appearing in the propagation of massless fields
(scalar, electromagnetic and gravitational) in the vicinities of a
D-dimensional Schwarzschild black hole. We find that at late times the fields
always exhibit a power-law falloff, but the power-law is highly sensitive to
the dimensionality of the spacetime. Accordingly, for odd D>3 we find that the
field behaves as t^[-(2l+D-2)] at late times, where l is the angular index
determining the angular dependence of the field. This behavior is entirely due
to D being odd, it does not depend on the presence of a black hole in the
spacetime. Indeed this tails is already present in the flat space Green's
function. On the other hand, for even D>4 the field decays as t^[-(2l+3D-8)],
and this time there is no contribution from the flat background. This power-law
is entirely due to the presence of the black hole. The D=4 case is special and
exhibits, as is well known, the t^[-(2l+3)] behavior. In the extra dimensional
scenario for our Universe, our results are strictly correct if the extra
dimensions are infinite, but also give a good description of the late time
behaviour of any field if the large extra dimensions are large enough.Comment: 6 pages, 3 figures, RevTeX4. Version to appear in Rapid
Communications of Physical Review
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