57 research outputs found
Application of functional genomics to primate endometrium: insights into biological processes
Endometrium is a dynamic tissue that responds on a cyclic basis to circulating levels of the ovarian-derived steroid hormones, estradiol and progesterone. Functional genomics has enabled a global approach to understanding gene regulation in whole endometrial tissue in the setting of a changing hormonal milieu. The proliferative phase of the cycle, under the influence of estradiol, has a preponderance of genes involved in DNA synthesis and cell cycle regulation. Interestingly, genes encoding ion channels and cell adhesion, as well as angiogenic factors, are also highly regulated in this phase of the cycle. After the LH surge, different gene expression profiles are uniquely observed in the early secretory, mid-secretory (window of implantation), and late secretory phases. The early secretory phase is notable for up-regulation of multiple genes and gene families involved in cellular metabolism, steroid hormone metabolism, as well as some secreted glycoproteins. The mid-secretory phase is characterized by multiple biological processes, including up-regulation of genes encoding secreted glycoproteins, immune response genes with a focus on innate immunity, and genes involved in detoxification mechanisms. In the late secretory phase, as the tissue prepares for desquamation, there is a marked up-regulation of an inflammatory response, along with matrix degrading enzymes, and genes involved in hemostasis, among others. This monograph reviews hormonal regulation of gene expression in this tissue and the molecular events occurring therein throughout the cycle derived from functional genomics analysis. It also highlights challenges encountered in using human endometrial tissue in translational research in this context
Polymer Film Supported Bimetallic Au–Ag Catalysts for Electrocatalytic Oxidation of Ammonia Borane in Alkaline Media
SECM study of solute partitioning and electron transfer at the ionic liquid/water interface
Comparative study of electron transfer reactions at the ionic liquid/water and organic/water interfaces
Electrochemical detection of lateral charge transport in metal complex-DNA monolayers synthesized on Si(1 1 1) electrodes
The Simulation and Research of Etching Function Based on Scanning Electrochemical Microscopy
Tetrathiafulvalene-functionalized Cavitands as Building Blocks for Redox Active Hemicarcerands
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