9 research outputs found
Binding Site of Loperamide: Automated Docking of Loperamide in Human mu- and delta-Opioid Receptors
No full textLoperamide is a piperidine analogue, acting as agonist on peripheral opioid receptors, exhibiting affinity and selectivity for the cloned μ human opioid receptor compared with the δ human opioid receptor. Automatic docking studies of loperamide, using AutoDock, on human μ- and δ-opioid receptors is described. Whilst no meaningful difference was detected concerning the docking of the arylpiperidine moiety, μ/δ selectivity could be explained as a different accommodation of the two phenyl groups in two lipophylic pockets of receptor
New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents.
No full textInhibition of intestinal motility and secretion by flavonoids in mice and rats: structure-activity relationships.
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Synthesis, antiinflammatory and antimicrobial activities of some 2,4-dichloro-5-fluorophenyl substituted arylidenetriazolothiazolidinones
No full textA new efficient synthesis of thiazolidine derivatives in the presence of Fe3O4@SiO2–SO3H nanoparticles as a magnetically separable catalyst
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