6 research outputs found
A Hepatocellular Adenoma in a Diet-induced Obese Mouse
A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53
weeks of age. Macroscopically, a protruding yellowish white nodule was observed
on the visceral surface of the left lateral lobe. Light microscopy demonstrated
clear demarcation from the compressed adjacent parenchyma, with loss of the
distinct lobular pattern. The proliferating cells of the lesion varied in shape
and showed cellular atypia and prominent nucleoli along with vacuoles of various
sizes. Some of the cells contained various-sized eosinophilic inclusion bodies
in their cytoplasm, and electron microscopy revealed the presence of lipid
droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were
observed as electron dense granular material in the rough endoplasmic reticulum,
with one or a few low density central cores. A diagnosis of hepatocellular
adenoma was made based on these findings
Coexistence of primary sclerosing cholangitis in a patient with myasthenia gravis
Myasthenia gravis (MG) is an immune-mediated disease that compromises the postsynaptic membrane of the neuromuscular junction. Primary sclerosing cholangitis (PSC) is considered an immune-mediated cholestatic liver disease. Both MG and PSC include an autoimmune pathogenesis, so there is some evidence that patients with MG or PSC have a higher risk of developing autoantibodies and other immune disorders than normal controls, but the coexistence of these two disorders has never been documented. We report a 40-year-old woman who presented with MG when she was 20 years old and developed PSC 20 years after a thymectomy. Liver biochemistry revealed cholestasis. Magnetic resonance imaging showed multifocal strictures and beads involving the intrahepatic bile ducts. A liver biopsy confirmed sclerosing cholangitis. Serological analysis demonstrated positive autoantibodies (Anti-nuclear antibodies, anti-smooth muscle antibodies). Repetitive stimulation had a decremental response, and antibodies to acetylcholine receptors were detectable. To our knowledge, this is the first case of PSC in a patient with MG. The main characteristics of both MG and PSC combination are discussed