Ege Bölgesi'nde yaşayan Blanus Strauchi (Bedriaga, 1884) (Amphisbaenia, Blanidae) populastonları üzerinde morfolojik bir araştırma

Bu çalışmada, Blanus strauchi’nin Ege Bölgesi’nde yaşayan populasyonları morfolojik açıdan değerlendirilmiştir. Ege Bölgesi’nde yapılan arazi çalışmaları sonucunda toplanan yeni örnekler ve müze örnekleri ile beraber toplamda 153 örnek incelenmiştir. Analiz için örnekler İzmir, Aydın, Denizli, Muğla ve Fethiye olmak üzere 5 gruba ayrılmıştır. Bu gruplardan Fethiye populasyonları diğer populasyonlardan özellikle infralabial plak sayısı ve prekloakal porların sayısı ve ventral medianda temas durumlarına göre ayrılmaktadır. Buna göre Fethiye haricinde Ege Bölgesi’nde Blanus s. strauchi, Fethiye civarında ise Blanus s. bedriagae alttürü yaşamaktadır

EXPOSURE TO MELAMINE FROM THE EARLY POSTNATAL PERIOD CAUSES NEPROTOXICITY: A HISTOPATHOLOGIC AND ULTRASTRUCTURAL STUDY

Objective: Melamine (mel), which is illegally added to formula to providing false-positive protein content, has caused acute renal failure in infants due to crystal formation. This study aimed to investigate the nephrotoxic effects of chronic low-dose mel exposure from the weaning period (supplementary food period)

Autologously transplanted dermis-derived cells alleviated monobenzone-induced vitiligo in mouse

Vitiligo is a depigmentation disease which affects skin and hair follicles with a prevalence of 0.5%-1% worldwide. In this study, we aimed to investigate treatmental potential of dermis-derived cells in monobenzone (MBEH)-induced mouse vitiligo model with light and electron microscopy. MBEH (40%) cream was topically applied to C57BL/6 mice until depigmentation occured in vitiligo and experimental groups. In experimental groups, dermis-derived cells obtained from back skin biopsy samples before induction of vitiligo, were injected intradermally to vitiligo mice. On Days 3 and 15 after cell transplantation to experimental groups, skin biopsies were compared with biopsies of control and vitiligo groups. Dermis-derived cells obtained from back skin biopsy samples of experimental groups showed nestin and versican immunoreactivity. Melanin in hair follicles of control group was detected by histochemical stainings (Haematoxylin and eosin and Fontana-Masson) whereas sparse melanin granules were observed in hair follicles of vitiligo group. In experimental groups, there was an increase in the number of hair follicles with melanin compared with vitiligo group. We observed MART-1 immunoreactive cells mostly around the hair follicles in control group and within dermis in vitiligo group. Electron microscopic investigation showed presence of melanosomes in hair follicles of control group and lacking in vitiligo group. In experimental groups, both type of hair follicles were observed with electron microscope. Our data suggest that autologously transplanted dermis-derived cells may be effective in vitiligo treatment by contrubuting to melanin production