Değişen Gündem ve Türkiye: 2009 YılıMedya Gündemi Üzerine Bir İnceleme

Enformasyonun haber formatındaki üretimi ve dağıtımıişlevini yerine getiren medya, kamusal alandaki tartışmaların en önemli belirleyicisi ve taşıyıcısıolarak kilit bir rol üstlenmektedir. Buna bağlıolarak haber medyasında öne çıkan konular ve bu konuların haberleştirilmesinde kullanılan dilsel pratikler genişbir inceleme alanıolarak ortaya çıkmaktadır. Bu çalışmada ise medya gündeminin çok sık değiştiği ya da değiştirildiği yönündeki tartışmaların hız kazandığıbir yıl olarak 2009 yılında, yaygın medyanın değişmez konu başlıkları, bu konulardan oluşanmedya gündemini kimin belirlediği, nasıl şekillendirdiği, gündemin değişim sıklığıve hızı, haber sunumunda öne çıkan çerçeveler gibi sorulara yanıtlar aranmıştır. Bu çerçevede 1 Ocak-31 Aralık 2009 tarihleri arasında yaygın medyaya mensup Akşam, Cumhuriyet, Hürriyet, Milliyet, Posta, Radikal, Sabah, Taraf, Yeni Şafak ve Zaman gazetelerinin manşet ve sürmanşetleri içerik analizi yöntemiyle incelenmiştir. Araştırma sonucunda 2009 yılında en fazla gündemde kalan konuların Ergenekon davasına ilişkin gelişmeler ve Kürt açılımıtartışmalarıolduğu saptanmıştır. Bu konularıilk defa manşetlerine taşıyan ve uzun süre gündemde kalmasınısağlayan gazeteler ise Zaman, Taraf ve Radikal’dir. Çalışmanın ortaya çıkardığıtemel bulgu, gazetelerin ateşleyici olayların dışında kalan zamanlarda kendi yayın politikalarıve ideolojik duruşlarıile gündemlerini belirledikleri şeklindedir. Nitekim haberde ideolojik kutuplaşmaya göre kendi düşüncelerini destekleyecek sözcükleri seçme, cümleleri kurma ve sunma davranışıCumhuriyet, Zaman ve Yeni Şafak gazetelerinde yoğun olarak görülmektedir

Hazır Beton Sektöründe Sipariş Maliyeti Yöntemi ve Bir Uygulama

Maliyet muhasebesi günümüz koşullarında sadece üretilen ürünün maliyetini tespit etmek amacıyla değil, bir işletme için mevcut durumun tespiti, geleceğe yönelik öngörüde bulunma ve planlama yapma fonksiyonlarını yerine getiren önemli bir yönetim faktörüdür. Yapılan çalışmada hazır beton sektöründe faaliyet gösteren bir işletmede maliyet muhasebesi prensiplerine uygun şekilde işleyen bir maliyet yönteminin uygulanabilirliği araştırılmıştır. Bu uygulama ile işletmenin üretim sürecinde ortaya çıkan gerçekçi maliyet verilerinin tespit edilmesi ve mevcut durumun analizinin yapılması amaçlanmıştır. İşletmenin gider yerleri belirlenmiş ve uygun maliyet sürücüleri kullanılarak dağıtımlar yapılmıştır. Sipariş maliyeti kartları ile toplam ve birim maliyetler tespit edilmiştir. Ayrıca yapılan dağıtımlara ilişkin ilgili yevmiye kayıtları yapılmıştır. Çalışma neticesinde işletmede, sektörün taşıdığı özellikler nedeniyle sipariş maliyeti yönteminin kullanılması önerilmiştir. Böylece işletmenin mali tablolarında yer alan veriler arası tutarsızlıkların giderilebileceği öngörülmüştür. Ayrıca bu yöntem yoluyla elde edilecek şeffaf veriler ile yönetimin karar alma süreci, işletmeye verimlilik ve karlılık olarak katkı sağlayacak bir sürece dönüşebilecektir. Çalışma esnasında karşılaşılan kısıtlar uygulama yapılan işletme tarafından sınırlı veri paylaşımı yapılması ve alınan maliyet verilerinin gizli kalmasının istenmesidir

An assessment of nasal and orbital parameters in human fetuses

Background: Nasal bone aplasia and hypoplasia have been reported on fetuses with aneuploidy. Trisomy 21 is one of the most common chromosomal abnormality detected in new-borns. The purpose of our study is to obtain data of some face parameters in Turkish fetal population and to contribute creation of reference ranges that may be used for prenatal diagnosis.Methods: This study was performed in 66 spontaneously aborted fetuses (47 second trimester and 19 third trimester) (28 male and 38 female) with no detectable external pathology or anomalies. Measurements were designed as nasal bone length (NBL), nose length (NL), nose width (NW), nostril width (NsW),                intraocular distance (IOD), innercanthal distance (ICD), outercanthal distance (OCD), orbital diameter (OD), biparietal diameter (BPD).Results: In comparison between genders, ICD and BPD averages were found significantly higher in male fetuses than female fetuses (P<0.05). There was not any statistically significant difference between averages of the values on the right and left. The difference between second and the third trimester was significant in terms of all parameters (P<0.05). A strong correlation was detected between gestational age and our parameters.Conclusions: Present study has contributed to create reference ranges of Turkish community. When importance of early diagnosis is considered, we believe that this data will be useful for clinicians

Serum YKL-40 levels as a novel marker of inflammation and endothelial dysfunction in patients with pseudoexfoliation syndrome

WOS: 000321700800013PubMed: 23661157Purpose To evaluate serum levels of YKL-40 in patients with pseudoexfoliation syndrome (PEX) in comparison with those of age-and sex-matched healthy subjects. Methods Forty patients with PEX (PEX group) and 40 age- and sex-matched control subjects (control group) were enrolled in the study. An enzyme immunoassay method using the commercially available test MicroVue YKL-40 was used to measure serum YKL-40 concentration. Systolic and diastolic blood pressures, serum levels of high sensitivity C-reactive protein (hsCRP), total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides were also examined. Results the mean age was 54.4 +/- 7.6 (ranging 41-65) years in each group. the mean serum YKL-40 level of the PEX group was significantly higher than that of the control group (P<0.001). in addition, the mean serum HsCRP, total cholesterol, LDL, and triglycerides levels were significantly higher, and mean serum HDL level was significantly lower in the PEX group than in the control group (all P<0.001, excluding both P = 0.002 for triglycerides and HDL levels). Further, the mean systolic and diastolic blood pressures were significantly higher in the PEX group than in the control group (P-1 = 0.001 and P-2 = 0.01, respectively). Conclusion We have shown a relationship between PEX and elevated serum levels of YKL-40. We imply that a better understanding of the role of YKL-40 in the pathogenesis of endothelial dysfunction and atherosclerosis is necessary to develop new therapies for preventing or treating PEX. Further studies are warranted to clarify the clinical relevance of these findings

Application of a short-term hydrological forecast system

Bu çalışmanın amacı kar erimesinin etkili olduğu dağlık memba havzaları için kısa dönemli akım tahmin sisteminin geliştirilmesidir. Çalışma alanları olarak seçilen dağlık Fırat ve Seyhan Havzaları, yüksek su potansiyeli, bu potansiyeli besleyen kar erimeleri, mansapta büyük ve önemli su yapılarının bulunması ile ön plana çıkmaktadırlar. Yağış-akış ilişkisinin simülasyonu için dağlık bölge uygulamalarında literatürde yaygın olarak kullanılan HBV modeli seçilmiştir. Sayısal Hava Tahmin (SHT) verisi olarak Mesoscale Model 5 (MM5) ve Weather Research and Forecast (WRF) model sonuçları kullanılmıştır. Hidrolojik model parametrelerinin gözlenen yağış, sıcaklık ve akım verileriyle kalibrasyon/doğrulama işleminin yapılmasının ardından, analizleri yapılan SHT verilerinin girdi olarak kullanılması ile 1 ve 2 günlük akım tahminleri elde edilmiştir. İleriye dönük akım tahminleri Delft-FEWS platformunda kapalı döngü şeklinde çalıştırılarak, geçmiş dönem tahmin simülasyonları gerçekleştirilmiş ve akım gözlemleri ile kıyaslanarak performans değerlendirmesi yapılmıştır. Elde edilen sonuçlar havzaların akış aşağısında bulunan su yapılarının daha verimli işletilmesine ve böylece ülke ekonomisine katkı sağlayabilecektir.This study aims to deploy a short term hydrological forecast system in snow dominated mountainous basins. The headwaters of Euphrates and Seyhan Basins, selected as study areas, stand out with their high water potential, snow melt feeding this potential and the presence of large and important water structures in the downstream. For the simulation of precipitation-runoff relationship, HBV model, a widely used model in the literature especially for mountainous regions, is utilized. Mesoscale Model 5 (MM5) and Weather Research and Forecast (WRF) model results are preferred as Numerical Weather Prediction (NWP) data. After calibration/validation of hydrological model parameters with observed precipitation, temperature and flow data, 1- and 2-day flow estimates are obtained using the analyzed NWP data as input. Hindcast simulations for the past period are implemented with a closed-loop structure on the Delft-FEWS platform, and performance evaluation is conducted by comparing them with streamflow observations. The results obtained may contribute to the more efficient operation of water structures located downstream of the basins and thus to the national economy

Real-life experiences with galcanezumab and predictors for treatment response in Turkey

BackgroundThe complexity of clinical practice extends far beyond the controlled settings of trials, and there is a need for real-world studies aimed at identifying which patients will respond to anti-CGRP monoclonal antibodies in different countries. This study aimed to investigate the efficacy and safety of galcanezumab in treating migraine in a real-life setting in Turkey, as well as identify predictors of treatment response.MethodsA total of 476 patients who diagnosed with migraine according to ICHD-3 criteria and treated with galcanezumab by headache specialists were voluntarily participated in this cross-sectional study. Galcanezumab is indicated for the prevention of migraine in adults who have at least 4 monthly migraine days in Turkey. All patients filled out a survey on Google Form that comprised 54 questions, addressing various aspects such as demographics, migraine characteristics, previous use of acute symptomatic medication, failures with preventive drug classes, comorbidities, most bothersome symptoms, as well as the interictal burden of migraine.ResultsAmong the participants, 89.3% reported that galcanezumab treatment was beneficial for them. A decrease in the frequency (80.0%), severity (85.7%), and acute medication usage for migraine attacks (71.4%) was reported with galcanezumab treatment. An adverse effect related to galcanezumab was reported in 16.3% of cases, but no serious adverse reactions were observed. Remarkably, 14.3% of participants reported no longer experiencing any headaches, and 18.9% did not require any acute treatment while receiving galcanezumab treatment. A logistic regression model showed that male gender, lack of ictal nausea, and previous failure of more than 2 prophylactic agents may predict the non-responders.ConclusionsThe first large series from Turkey showed that galcanezumab treatment is safe and effective in most of the patients diagnosed with migraine by headache experts in the real-life setting. Patients reported a significant decrease in both ictal and interictal burden of migraine and expressed satisfaction with this treatment

COVID-19 vaccination-related headache showed two different clusters in the long-term course: A prospective multicenter follow-up study (COVA-Head Study)

BackgroundAlthough acute headache following COVID-19 vaccination is widely acknowledged, the long-term progression of these headaches remains poorly understood. Our objective was to identify various phenotypes of prolonged or worsened headaches associated with COVID-19 vaccination and document any changes in these phenotypes over an extended period. Additionally, we aimed to document the diverse headache presentations among patients with pre-existing primary headaches.MethodsA multinational, prospective observational study was conducted to investigate prolonged or worsened headaches associated with COVID-19 vaccination. Questionnaires assessing COVID-19 vaccination-related headaches at three time points (initial visit, 3rd month follow-up, and 6th month follow-up) were developed for the study. Headache specialists/clinicians evaluated patients using these questionnaires in a prospective manner. Repeated K-means cluster analysis was performed to identify patient profiles with prolonged or worsened headaches related to COVID-19 vaccination.ResultsAmong the 174 patients included in the study, there was a female-to-male ratio of 128 (73.6%) to 46 (26.4%). The mean age of the patient group was 45.2 +/- 13.3 years, and 107 patients (61.5%) had a pre-existing history of primary headaches. Through the analysis, two major clusters were identified based on headache characteristics at each visit. During the first visit (n = 174), Cluster 1 primarily comprised patients with a history of primary headaches, frontal localization of pain, throbbing pain type, more severe headaches accompanied by symptoms such as nausea, phonophobia, photophobia, and osmophobia, and worsened by physical activity. In contrast, Cluster 2 consisted of patients with longer headache durations (over one month) and a stabbing/pressing quality of pain. Patients in Cluster 1 had a higher prevalence of migraine as the pre-existing primary headache disorder compared to Cluster 2 (90.48% vs. 68.18%, respectively; p = 0.005).ConclusionThe identification of two distinct phenotypes of prolonged or worsened headaches related to COVID-19 vaccination can provide valuable clinical insights. Having an awareness of the potential worsening of headaches following COVID-19 vaccination, particularly in patients with a primary headache disorder such as migraine, can help clinicians and headache experts anticipate and adjust their treatment strategies accordingly. This knowledge can aid in preplanning treatment modifications and optimize patient care

The relationship of plasma catestatin concentrations with metabolic and vascular parameters in untreated hypertensive patients: Influence on high-density lipoprotein cholesterol

Objective: Catestatin has several cardiovascular actions, in addition to diminished sympatho-adrenal flow. Decreased plasma catestatin levels may reflect a predisposition for the development of hypertension and metabolic disorders. We planned to investigate the possible roles of catestatin in untreated hypertensive patients. As a secondary objective, we compared catestatin concentrations of healthy subjects with those of hypertensive patients in order to understand whether catestatin is increased reactively or diminished at onset. Methods: Our study was cross-sectional and observational. The patient group, comprising 109 consecutive untreated hypertensive patients without additional systemic or coronary heart disease, underwent evaluations of plasma catestatin, waist circumference, lipid parameters, left ventricular mass, carotid intima-media thickness, and flow-mediated dilation of the brachial artery. Additionally, we measured catestatin con- centrations of 38 apparently healthy subjects without any disease using a commercial enzyme-linked immunosorbent assay kit. Results: We documented increased catestatin concentrations in previously untreated hypertensive patients compared to healthy controls (2.27±0.83 vs. 1.92±0.49 ng/mL, p=0.004). However, this association became insignificant after adjustments for age, gender, height, and weight. Within the patient group, catestatin levels were significantly higher in females. Among all study parameters, age, high-density lipoprotein cholesterol (HDL-C) corre- lated positively to plasma catestatin, whereas triglycerides, hemoglobin, and left ventricular mass correlated negatively to plasma catestatin. We could not detect an association between vascular parameters and catestatin. Catestatin levels were significantly elevated with increasing HDL-C (1.91±0.37, 2.26±0.79, and 3.1±1.23 ng/mL in patients with HDL-C 60 mg/dL, respectively). Multiple linear regression analysis revealed age (beta: 0.201, p=0.041) and HDL-C (beta: 0.390, p<0.001) as independent correlates of plasma catestatin concentration. Additionally, male gender (beta:-0.330, p=0.001) and plasma catestatin (beta: 0.299, p=0.002) were significantly associated with HDL-C concentrations. Conclusion: We documented that plasma catestatin is an independent predictor of high-density lipoprotein cholesterol. In addition to antihy- pertensive effects, catestatin appears to be related to improved lipid and metabolic profiles. Coexistence of low catestatin levels with low HDL-C may provide a probable mechanism for the predictive value of low HDL-C for increased hypertension and cardiovascular events

Plasma catestatin concentration is independently correlated with high-density lipoprotein cholesterol levels in untreated hypertensive patients

29th Turkish Cardiology Congress of the Turkish-Society-of-Cardiology (TSC) with International Participation -- OCT 26-29, 2013 -- Antalya, TURKEYCetin, Mustafa/0000-0001-6342-436X; Durakoglugil, Emre/0000-0001-5268-4262WOS: 000329858400426Purpose Catestatin (CST), a novel peptide derived from Chromogranin A, has diverse cardiovascular actions in addition to diminished sympathoadrenal flow. We intended to investigate metabolic and vascular associations of CST.Turkish Soc Cardio