DNN-based Voice Conversion with Auxiliary Phonemic Information to Improve Intelligibility of Glossectomy Patients' Speech

In this paper, we propose using phonemic information in addition to acoustic features to improve the intelligibility of speech uttered by patients with articulation disorders caused by a wide glossectomy. Our previous studies showed that voice conversion algorithm improves the quality of glossectomy patients' speech. However, losses in acoustic features of glossectomy patients' speech are so large that the quality of the reconstructed speech is low. To solve this problem, we explored potentials of several additional information to improve speech intelligibility. One of the candidates is phonemic information, more specifically Phoneme Labels as Auxiliary input (PLA). To combine both acoustic features and PLA, we employed a DNN-based algorithm. PLA is represented by a kind of one-of-k vector, i.e., PLA has a weight value (<; 1.0) that gradually changes in time axis, whereas one-of-k has a binary value (0 or 1). The results showed that the proposed algorithm reduced the mel-frequency cepstral distortion for all phonemes, and almost always improved intelligibility. Notably, the intelligibility was largely improved in phonemes /s/ and /z/, mainly because the tongue is used to sustain constriction to produces these phonemes. This indicates that PLA works well to compensate the lack of a tongue

Polarization Jumps across Topological Phase Transitions in Two-dimensional Systems

In topological phase transitions involving a change in topological invariants such as the Chern number and the $\mathbb{Z}_2$ topological invariant, the gap closes, and the electric polarization becomes undefined at the transition. In this paper, we show that the jump of polarization across such topological phase transitions in two dimensions is described in terms of positions and monopole charges of Weyl points in the intermediate Weyl semimetal phase. We find that the jump of polarization is described by the Weyl dipole at $\mathbb{Z}_2$ topological phase transitions and at phase transitions without any change in the value of the Chern number. Meanwhile, when the Chern number changes at the phase transition, the jump is expressed in terms of the relative positions of Weyl points measured from a reference point in the reciprocal space.Comment: 12pages, 10 figure

QAC RESISTANCE OF P. AERUGINOSA

The adaptation mechanism of Pseudomonas aeruginosa ATCC 10145 to quaternary ammonium compounds (QACs) was investigated. A P. aeruginosa strain with adapted resistance to QACs was developed by a standard broth dilution method. It was revealed that P. aeruginosa exhibited remarkable resistance to N-dodecylpyridinium iodide (P-12), whose structure is similar to that of a common disinfectant, cetylpyridinium chloride. Adapted resistance to benzalkonium chloride (BAC), which is commonly used as a disinfectant, was also observed in P. aeruginosa. Moreover, the P-12-resistant strain exhibited cross-resistance to BAC. Analysis of the outer membrane protein of the P-12-resistant strain by two-dimensional polyacrylamide gel electrophoresis showed a significant increase in the level of expression of a protein (named OprR) whose molecular mass was approximately 26 kDa. The actual function of OprR is not yet clear; however, OprR was expected to be an outer membrane-associated protein with homology to lipoproteins of other bacterial species, according to a search of the National Center for Biotechnology Information website with the BLAST program by use of the N-terminal sequence of OprR. A correlation between the level of expression of OprR and the level of resistance of P. aeruginosa to QACs was observed by using a PA2800 gene knockout mutant derived from the P-12-resistant strain. The knockout mutant recovered susceptibility not only to P-12 but also to BAC. These results suggested that OprR significantly participated in the adaptation of P. aeruginosa to QACs, such as P-12 and BAC

Bone marrow transplantation improves outcome in a mouse model of congenital muscular dystrophy

AbstractWe examined whether pathogenesis in dystrophin-deficient (mdx) mice and laminin-α2-deficient (dy) mice is ameliorated by bone marrow transplantation (BMT). Green fluorescent protein (GFP) mice were used as donors. In mdx mice, BMT failed to produce any significant differences in muscle pathology, although some GFP-positive fibers with restored dystrophin expression were observed. In contrast, in the dy mice, BMT led to a significant increase in lifespan and an increase in growth rate, muscle strength, and respiratory function. We conclude that BMT improved outcome in dy mice but not mdx mice

Novel Charge Ordering in the Trimer Iridium Oxide BaIrO3

We have prepared polycrystalline samples of the trimer Ir oxide BaIrO3 with face-shared Ir3O12 trimers, and have investigated the origin of the phase transition at 182 K by measuring resistivity, thermopower, magnetization and synchrotron x-ray diffraction. We propose a possible electronic model and transition mechanism, starting from a localized electron picture on the basis of the Rietveld refinement. Within this model, BaIrO3 can be basically regarded as a Mott insulator, when the Ir3O12 trimer is identified to one pseudo-atom or one lattice site. The transition can be viewed as a transition from the Mott insulator phase to a kind of charge ordered insulator phase.Comment: 8 pages 5 figures, Crystals (in press