Molecular fingerprinting of radiation resistant tumors: Can we apprehend and rehabilitate the suspects?

Radiation therapy continues to be one of the more popular treatment options for localized prostate cancer. One major obstacle to radiation therapy is that there is a limit to the amount of radiation that can be safely delivered to the target organ. Emerging evidence suggests that therapeutic agents targeting specific molecules might be combined with radiation therapy for more effective treatment of tumors. Recent studies suggest that modulation of these molecules by a variety of mechanisms (e.g., gene therapy, antisense oligonucleotides, small interfering RNA) may enhance the efficacy of radiation therapy by modifying the activity of key cell proliferation and survival pathways such as those controlled by Bcl-2, p53, Akt/PTEN and cyclooxygenase-2. In this article, we summarize the findings of recent investigations of radiosensitizing agents in the treatment of prostate cancer

Técnica de incidente crítico e seu uso na Enfermagem: revisão integrativa da literatura

Revisão integrativa da literatura realizada nas bases de dados LILACS, MEDLINE e SciELO no período de 2000 a 2010, com os objetivos de sintetizar o conhecimento produzido nas pesquisas em enfermagem que utilizaram a técnica de incidente crítico e identificar o uso e a aplicabilidade dessa técnica como referencial metodológico. Os achados perfizeram um total de dezessete artigos científicos e demonstraram que o Brasil se destacou com 76,5% de publicações. A análise e categorização, segundo os três elementos da técnica, ocorreram em 76,0% dos artigos. A categoria "análise de iatrogenias" provocadas pelos profissionais de saúde se destacou quanto à utilização da técnica de incidente crítico. A revisão integrativa possibilitou a construção de uma síntese do conhecimento científico sobre essa técnica, além de demonstrar sua ampla contribuição para a melhoria da assistência de enfermagem e de saúde

Merging without alienating: interventions promoting cross-cultural organizational integration and their limitations

Foreign direct investment, particularly cross-border mergers and acquisitions can spawn a range of individual-level outcomes from cross-cultural adjustment and synergistic learning, on the positive side, to work alienation, on the negative. Unsuccessful navigation of these individual-level outcomes leads to failed integration that can seriously affect the realization of desired organizational outcomes such as successful technology transfer, knowledge-sharing, and the general realization of global growth. By means of an iterative between-methods triangulation, the study surfaces cross-cultural work alienation as a phenomenon that can limit the overall success of such ventures, and identifies interventions that help to promote successful post-merger integration. Journal of International Business Studies (2009) 40, 468–489. doi:10.1057/jibs.2008.80

Microbiome of Drinking Water Distribution Systems

International audienc