Paulista registry of glomerulonephritis: 5-year data report

Background. The Paulista Registry of Glomerulopathies was created in May 1999 and comprises several centres of Sao Paulo, the most populous Brazilian State, that concentrates people from all regions of the country who look for health care. Methods. This report includes data from 2086 patients from Brazil submitted to renal biopsy due to the presumed diagnosis of glomerular diseases, registered prospectively since May 1999 until January 2005. Data were collected by the integrants of the 11 centres involved, utilizing a standardized questionnaire. Results. The mean age of the patients was 34.5 +/- 14.6 years. Primary glomerular diseases were more frequent in males (55.1%) than in females; on the other hand, secondary glomerular diseases were more frequent in females (71.8%). The most common clinical presentation was nephrotic syndrome and the frequency of hypertension, at this time, was 55.5%. There was a predominance of indication of biopsies in the third, fourth and fifth decades of life. The most common primary glomerular diseases were focal and segmental glomerulosclerosis (29.7%), followed by membranous nephropathy (20.7%), IgA nephropathy (17.8%), minimal change disease (9.1%), membranoproliferative glomerulonephritis (7%), crescentic glomerulonephritis (4.1%), advanced chronic glomerulopathy (4%), non-IgA mesangial glomerulonephritis (3.8%), diffuse proliferative glomerulonephritis (2.5%), focal segmental proliferative glomerulonephritis (1%) and others (0.3%). The most frequent secondary glomerular disease was lupus nephritis, corresponding to 66.2% of the cases, followed by post-infectious glomerulonephritis (12.5%), diabetic nephropathy (6.2%), diseases associated to paraproteinaemia (4.9%), hereditary diseases (4.6%), vasculitis (3.2%), malignancies (0.9.%), secondary focal segmental glomerulosclerosis (0.6%) and others (0.9%). Conclusion. Focal segmental glomerulosclerosis was the most frequent primary glomerular disease, followed by membranous nephropathy and IgA nephropathy. Lupus nephritis predominated over all the other secondary glomerular diseases.21113098310

Activity and viability of methanogens in anaerobic digestion of unsaturated and saturated long-chain fatty acids

Lipids can be anaerobically digested to methane, but methanogens are often considered to be highly sensitive to the long-chain fatty acids (LCFA) deriving from lipids hydrolysis. In this study, the effect of unsaturated (oleate [C18:1]) and saturated (stearate [C18:0] and palmitate [C16:0]) LCFA toward methanogenic archaea was studied in batch enrichments and in pure cultures. Overall, oleate had a more stringent effect on methanogens than saturated LCFA, and the degree of tolerance to LCFA was different among distinct species of methanogens. Methanobacterium formicicum was able to grow in both oleate- and palmitate-degrading enrichments (OM and PM cultures, respectively), whereas Methanospirillum hungatei only survived in a PMculture. The two acetoclastic methanogens tested, Methanosarcina mazei and Methanosaeta concilii, could be detected in both enrichment cultures, with better survival in PM cultures than inOMcultures. Viability tests using live/dead staining further confirmed that exponential growth-phase cultures of M. hungatei are more sensitive to oleate than are M. formicicum cultures; exposure to 0.5 mMoleate damaged 99% 1% of the cell membranes of M. hungatei and 53% 10% of the cell membranes of M. formicicum. In terms of methanogenic activity, M. hungatei was inhibited for 50% by 0.3, 0.4, and 1mMoleate, stearate, and palmitate, respectively. M. formicicum was more resilient, since 1mMoleate and>4mMstearate or palmitate was needed to cause 50% inhibition on methanogenic activity.This study was financially supported by FEDER funds through the Operational Competitiveness Programme (COMPETE) and by national funds through the Portuguese Foundation for Science and Technology (FCT) in the frame of the projects FCOMP-01-0124-FEDER-007087 and FCOMP-01-0124-FEDER-014784. Financial support from the FCT and the European Social Fund (POPH-QREN) through Ph.D. grant SFRH/BD/48960/2008 to A.F.S. is also acknowledged. A.J.M.S. was supported by grants from ALW-TOP (project 700.55.343) and ERC (project 323009)

Regionalização como estratégia para a definição de políticas públicas de controle de homicídios Regionalization as a strategy for the definition of homicide-control public policies

Neste artigo, analisamos a distribuição espacial das taxas de homicídios no Estado de Minas Gerais, Brasil, utilizando dados do Sistema de Informações de Mortalidade do Ministério da Saúde (SIM-MS), no período de 1996 a 2000. Os dados populacionais utilizados para o cálculo das taxas também foram obtidos através do MS. Diante da grande extensão territorial do Estado, utilizamos uma metodologia estatística desenvolvida recentemente, implementada no programa SKATER, para a geração de conglomerados espaciais homogêneos. Como resultado, obtivemos 24 conglomerados espaciais, nos quais os municípios semelhantes em relação às taxas de homicídios ficaram agrupados. A partir desses resultados, discutimos a possibilidade da criação de "Núcleos de Gerenciamento em Segurança Pública", que permitiriam a implementação de políticas públicas voltadas para o controle e a diminuição de homicídios em cidades com características semelhantes no que diz respeito a esse tipo de crime.<br>This article analyzes the spatial distribution of homicide rates in Minas Gerais State, Brazil, using data from the Ministry of Health Mortality Information System (SIM/MS) from 1996 to 2000. Population data used to calculate rates were also obtained from the Brazilian Ministry of Health. Minas Gerais has a large territory, so the study used a recently developed statistical methodology implemented in the SKATER software to generate homogeneous spatial clusters. The technique obtained 24 spatial clusters, in which municipalities with similar homicide rates were aggregated. Using these results, the authors discuss the possible creation of "public security administration areas" that would allow the implementation of public policies aimed at controlling and diminishing homicides in municipalities with similar characteristics for this type of crime

Cognitive representations in low back pain in patients receiving chiropractic versus physiotherapy treatment

This study focused on cognitive representations of low back pain patients receiving chiropractic (n = 213) versus physiotherapy treatment (n = 125). Variables assessed included satisfaction with care, illness perceptions, beliefs about pain and medicines, attitudes towards doctors and medicine, suffering, adherence and functional incapacity. In the chiropractic treatment, functional incapacity was predicted by painful symptoms, suffering and personal control, and in the physiotherapy treatment by age, pain intensity, positive suffering, care satisfaction, illness identity and medication adherence. The groups differed on all cognitive variables assessed. Interventions should take into consideration cognitive dimensions, across treatment modalities.info:eu-repo/semantics/submittedVersio