Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development

Background: Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3). KDM5C is expressed in the brain and skeletal muscles of humans and is associated with various biologically significant processes. KDM5C is known to be associated with X-linked mental retardation and is also involved in the development of cancer. However, the developmental significance of KDM5C has not been explored yet. In the present study, we investigated the physiological roles of KDM5C during Xenopus laevis embryonic development. Results: Loss-of-function analysis using kdm5c antisense morpholino oligonucleotides indicated that kdm5c knockdown led to small-sized heads, reduced cartilage size, and malformed eyes (i.e., small-sized and deformed eyes). Molecular analyses of KDM5C functional roles using whole-mount in situ hybridization, -galactosidase staining, and reverse transcription-polymerase chain reaction revealed that loss of kdm5c resulted in reduced expression levels of neural crest specifiers and genes involved in eye development. Furthermore, transcriptome analysis indicated the significance of KDM5C in morphogenesis and organogenesis. Conclusion: Our findings indicated that KDM5C is associated with embryonic development and provided additional information regarding the complex and dynamic gene network that regulates neural crest formation and eye development. This study emphasizes the functional significance of KDM5C in Xenopus embryogenesis; however, further analysis is needed to explore the interactions of KDM5C with specific developmental genes

Gender in Politics

Women’s political participation and representation vary dramatically within and between countries. We selectively review the literature on gender in politics, focusing on women’s formal political participation. We discuss both traditional explanations for women’s political participation and representation, such as the supply of women and the demand for women, and newer explanations such as the role of international actors and gender quotas. We also ask whether women are distinctive—does having more women in office make a difference to public policy? Throughout the review we demonstrate that a full understanding of women’s political representation requires both deep knowledge of individual cases such as the United States and broad knowledge comparing women’s participation across countries. We end with four recommended directions for future research: (a) globalizing theory and research, (b) expanding data collection, (c) remembering alternative forms of women’s agency, and (d ) addressing intersectionality

Biotic interactions between saproxylic insect species

Biotic interactions between saproxylic insect specie