A Low Dimensional Framework for Exact Polygon-to-Polygon Occlusion Queries

Despite the importance of from-region visibility computation in computer graphics, efficient analytic methods are still lacking in the general 3D case. Recently, different algorithms have appeared that maintain occlusion as a complex of polytopes in Plücker space. However, they suffer from high implementation complexity, as well as high computational and memory costs, limiting their usefulness in practice. In this paper, we present a new algorithm that simplifies implementation and computation by operating only on the skeletons of the polyhedra instead of the multi-dimensional face lattice usually used for exact occlusion queries in 3D. This algorithm is sensitive to complexity of the silhouette of each occluding object, rather than the entire polygonal mesh of each object. An intelligent feedback mechanism is presented that greatly enhances early termination by searching for apertures between query polygons. We demonstrate that our technique is several times faster than the state of the art

Improvement of Radwaste Management System at Bilibinskaya NPP in the Far North Conditions -13456

ABSTRACT Since 2009 Bilibinskay NPP is getting started to prepare to the decommissioning in the Far North conditions. Bilibinskaya NPP is located in the Far North of Russian Federation in Chukotka region. Since 1974 it operates 4 units EGP-6 with the capacity of 48 MW each. According to the contract, SIA Radon has performed the following works: -LLRW disposal safety analysis, -The technology of spent ion-exchanger and salt residue solidification is proposed, -Expected radwaste (till 2027) management economical analysis -Technical proposals for LLRW and IRW management

Fluxes and Warping for Gauge Couplings in F-theory

We compute flux-dependent corrections in the four-dimensional F-theory effective action using the M-theory dual description. In M-theory the 7-brane fluxes are encoded by four-form flux and modify the background geometry and Kaluza-Klein reduction ansatz. In particular, the flux sources a warp factor which also depends on the torus directions of the compactification fourfold. This dependence is crucial in the derivation of the four-dimensional action, although the torus fiber is auxiliary in F-theory. In M-theory the 7-branes are described by an infinite array of Taub-NUT spaces. We use the explicit metric on this geometry to derive the locally corrected warp factor and M-theory three-from as closed expressions. We focus on contributions to the 7-brane gauge coupling function from this M-theory back-reaction and show that terms quadratic in the internal seven-brane flux are induced. The real part of the gauge coupling function is modified by the M-theory warp factor while the imaginary part is corrected due to a modified M-theory three-form potential. The obtained contributions match the known weak string coupling result, but also yield additional terms suppressed at weak coupling. This shows that the completion of the M-theory reduction opens the way to compute various corrections in a genuine F-theory setting away from the weak string coupling limit.Comment: 46 page

Five-Brane Superpotentials, Blow-Up Geometries and SU(3) Structure Manifolds

We investigate the dynamics of space-time filling five-branes wrapped on curves in heterotic and orientifold Calabi-Yau compactifications. We first study the leading N=1 scalar potential on the infinite deformation space of the brane-curve around a supersymmetric configuration. The higher order potential is also determined by a brane superpotential which we compute for a subset of light deformations. We argue that these deformations map to new complex structure deformations of a non-Calabi-Yau manifold which is obtained by blowing up the brane-curve into a four-cycle and by replacing the brane by background fluxes. This translates the original brane-bulk system into a unifying geometrical formulation. Using this blow-up geometry we compute the complete set of open-closed Picard-Fuchs differential equations and identify the brane superpotential at special points in the field space for five-branes in toric Calabi-Yau hypersurfaces. This has an interpretation in open mirror symmetry and enables us to list compact disk instanton invariants. As a first step towards promoting the blow-up geometry to a supersymmetric heterotic background we propose a non-Kaehler SU(3) structure and an identification of the three-form flux.Comment: 95 pages, 4 figures; v2: Minor corrections, references update

Food effects on statolith composition of the common cuttlefish (Sepia officinalis)

The concentration of trace elements within cephalopod statoliths can provide a record of the environmental characteristics at the time of calcification. To reconstruct accurately the environmental characteristics at the time of calcification, it is important to understand the influence of as many factors as possible. To test the hypothesis that the elemental composition of cuttlefish statoliths could be influenced by diet, juvenile Sepia officinalis were fed either shrimp Crangon sp. or fish Clupea harengus under equal temperature and salinity regimes in laboratory experiments. Element concentrations in different regions of the statoliths (core–lateral dome–rostrum) were determined using laser ablation inductively coupled plasma mass spectrometry (LA- ICPMS). The ratios of Sr/Ca, Ba/Ca, Mn/Ca and Y/Ca in the statolith’s lateral dome of shrimp-fed cuttlefish were significantly higher than in the statolith’s lateral dome of fish-fed cuttlefish. Moreover, significant differences between statolith regions were found for all analysed elements. The fact that diet adds a considerable variation especially to Sr/Ca and Ba/Ca must be taken into account in future micro-chemical statolith studies targeting cephalopod’s life history

The optimization of in vitro high-throughput chemical lysis of Escherichia coli. Application to ACP domain of the polyketide synthase ppsC from Mycobacterium tuberculosis

Protein production in Escherichia coli involves high-level expression in a culture, followed by harvesting of the cells and finally their disruption, or lysis, to release the expressed proteins. We compare three high-throughput chemical lysis methods to sonication, using a robotic platform and methodologies developed in our laboratory [1]. Under the same expression conditions, all lysis methods varied in the degree of released soluble proteins. With a set of 96 test proteins, we used our split GFP to quantify the soluble and insoluble protein fractions after lysis. Both the amount of soluble protein and the percentage recovered in the soluble fraction using SoluLyse® were well correlated with sonication. Two other methods, Bugbuster® and lysozyme, did not correlate well with sonication. Considering the effects of lysis methods on protein solubility is especially important when accurate protein solubility measurements are needed, for example, when testing adjuvants, growth media, temperature, or when establishing the effects of truncation or sequence variation on protein stability

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although hBD's are primarily expressed by epithelial cells, we show that human platelets express hBD-1 that has both predicted and novel antibacterial activities. We observed that activated platelets surround Staphylococcus aureus (S. aureus), forcing the pathogens into clusters that have a reduced growth rate compared to S. aureus alone. Given the microbicidal activity of β-defensins, we determined whether hBD family members were present in platelets and found mRNA and protein for hBD-1. We also established that hBD-1 protein resided in extragranular cytoplasmic compartments of platelets. Consistent with this localization pattern, agonists that elicit granular secretion by platelets did not readily induce hBD-1 release. Nevertheless, platelets released hBD-1 when they were stimulated by α-toxin, a S. aureus product that permeabilizes target cells. Platelet-derived hBD-1 significantly impaired the growth of clinical strains of S. aureus. hBD-1 also induced robust neutrophil extracellular trap (NET) formation by target polymorphonuclear leukocytes (PMNs), which is a novel antimicrobial function of β-defensins that was not previously identified. Taken together, these data demonstrate that hBD-1 is a previously-unrecognized component of platelets that displays classic antimicrobial activity and, in addition, signals PMNs to extrude DNA lattices that capture and kill bacteria