759 research outputs found
The nature of the continuum limit in strongly coupled quenched QED
We review the results of large scale simulations of noncompact quenched
which use spectrum and Equation of State calculations to determine the theory's
phase diagram, critical indices, and continuum limit. The resulting anomalous
dimensions are in good agreement with Schwinger-Dyson solutions of the ladder
graphs of conventional and they satisfy the hyperscaling relations
expected of a relativistic renormalizable field theory. The spectroscopy
results satisfy the constraints of the Goldstone mechanism and PCAC, and may be
indicative of Technicolor versions of the Standard Model which are strongly
coupled at short distances.Comment: (talk given at the XXVI ICHEP, Dallas, TX, Aug 6-12 92), 6 pp.,
ILL-(TH)-92-#2
Degenerate distributions in complex Langevin dynamics: one-dimensional QCD at finite chemical potential
We demonstrate analytically that complex Langevin dynamics can solve the sign
problem in one-dimensional QCD in the thermodynamic limit. In particular, it is
shown that the contributions from the complex and highly oscillating spectral
density of the Dirac operator to the chiral condensate are taken into account
correctly. We find an infinite number of classical fixed points of the Langevin
flow in the thermodynamic limit. The correct solution originates from a
continuum of degenerate distributions in the complexified space.Comment: 20 pages, several eps figures, minor comments added, to appear in
JHE
Large-N spacetime reduction and the sign and silver-blaze problems of dense QCD
We study the spacetime-reduced (Eguchi-Kawai) version of large-N QCD with
nonzero chemical potential. We explore a method to suppress the sign
fluctuations of the Dirac determinant in the hadronic phase; the method employs
a re-summation of gauge configurations that are related to each other by center
transformations. We numerically test this method in two dimensions, and find
that it successfully solves the silver-blaze problem. We analyze the system
further, and measure its free energy F, the average phase theta of its Dirac
determinant, and its chiral condensate . We show that F and
are independent of mu in the hadronic phase but that, as chiral
perturbation theory predicts, the quenched chiral condensate drops from its
mu=0 value when mu~(pion mass)/2. Finally, we find that the distribution of
theta qualitatively agrees with further, more recent, predictions from chiral
perturbation theory.Comment: 43 pages, 17 figure
Properties of the QCD thermal transition with Nf=2+1 flavors of Wilson quark
We study properties of the thermal transition in QCD, using anisotropic, fixed-scale lattice simulations with Nf=2+1 flavors of Wilson fermion. Observables are compared for two values of the pion mass, focusing on chiral properties. Results are presented for the Polyakov loop, various susceptibilities, the chiral condensate and its susceptibility, and the onset of parity doubling in the light and strange baryonic sector
Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12
Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling pathways has become a novel therapeutic approach in CLL. The tyrosine kinase inhibitor dasatinib inhibits migration of several cell lines from solid-organ tumours, but effects on CLL cells have not been reported. We studied the effect of clinically achievable concentrations of dasatinib on signaling induced by the chemokine CXCL12 through its' receptor CXCR4, which is highly expressed on CLL cells. Dasatinib pre-treatment inhibited Akt and ERK phosphorylation in CLL cells upon stimulation with CXCL12. Dasatinib also significantly diminished the rapid increase in actin polymerisation observed in CLL cells following CXCL12 stimulation. Moreover, the drug significantly inhibited chemotaxis in a transwell assay, and reduced the percentage of cells able to migrate beneath a CXCL12-expressing murine stromal cell line. Dasatinib also abrogated the anti-apoptotic effect of prolonged CXCL12 stimulation on cultured CLL cells. These data suggest that dasatinib, akin to other small molecule kinase inhibitors targeting the B-cell receptor signaling pathway, may redistribute CLL cells from protective tissue niches to the peripheral blood, and support the investigation of dasatinib in combination strategies
Lattice QCD at nonzero temperature and density
Abstract We discuss some selected recent developments in the field of lattice QCD at nonzero temperature and density, describing in particular the transition from the hadronic gas to the quark-gluon plasma, as seen in simulations using Wilson fermions.</jats:p
Over-Selectivity is Related to Autism Quotient and Empathizing, But not to Systematizing
The relationships of autism quotient (AQ), systematizing (SQ), and empathizing (EQ), with over-selectivity were explored to assess whether over-selectivity is implicated in complex social skills, which has been assumed, but not experimentally examined. Eighty participants (aged 18–60) were trained on a simultaneous discrimination task (AB+CD−), and tested in extinction on the degree to which they had learned about both elements of the reinforced (AB) compound. Higher AQ and lower EQ scorers demonstrated greater over-selectivity, but there was no relationship between SQ and over-selectivity. These results imply that high AQ scorers perform similarly to individuals with ASD on this cognitive task, and that over-selectivity may be related to some complex social skills, like empathy
Mixed Climatology, Non-synoptic Phenomena and Downburst Wind Loading of Structures
Modern wind engineering was born in 1961, when Davenport published a paper in which meteorology, micrometeorology, climatology, bluff-body aerodynamics and structural dynamics were embedded within a homogeneous framework of the wind loading of structures called today \u201cDavenport chain\u201d. Idealizing the wind with a synoptic extra-tropical cyclone, this model was so simple and elegant as to become a sort of axiom. Between 1976 and 1977 Gomes and Vickery separated thunderstorm from non-thunderstorm winds, determined their disjoint extreme distributions and derived a mixed model later extended to other Aeolian phenomena; this study, which represents a milestone in mixed climatology, proved the impossibility of labelling a heterogeneous range of events by the generic term \u201cwind\u201d. This paper provides an overview of this matter, with particular regard to the studies conducted at the University of Genova on thunderstorm downbursts
Cloacal Bacterial Diversity Increases with Multiple Mates: Evidence of Sexual Transmission in Female Common Lizards
Sexually transmitted diseases have often been suggested as a potential cost of multiple mating and as playing a major role in the evolution of mating systems. Yet there is little empirical data relating mating strategies to sexually transmitted microorganisms in wild populations. We investigated whether mating behaviour influences the diversity and composition of cloacal assemblages by comparing bacterial communities in the cloaca of monandrous and polyandrous female common lizards Zootoca vivipara sampled after the mating period. We found that polyandrous females harboured more diverse communities and differed more in community composition than did monandrous females. Furthermore, cloacal diversity and variability were found to decrease with age in polyandrous females. Our results suggest that the higher bacterial diversity found in polyandrous females is due to the sexual transmission of bacteria by multiple mates. The impact of mating behaviour on the cloacal microbiota may have fitness consequences for females and may comprise a selective pressure shaping the evolution of mating systems
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