The Permian Cornubian granite batholith, SW England; part 2: gravity anomalies, structure, and state of isostasy

A new compilation of Bouguer gravity anomaly data has been used, together with forward and inverse modeling, to reappraise the structure, volume, and state of isostasy of the Cornubian batholith of SW England. We show the individual plutons that comprise the batholith are, on average, ∼10−11 km thick, are outward-sloping in their upper 2−3 km, and are underlain by roots which protrude downward into the middle crust. The batholith volume is estimated within the range of 76,367 ± 17,286 km3, significantly larger than previous estimates. Granite outcrops correlate with elevated topography, and mass balance calculations show that the mass deficiency of the granites relative to their host metasedimentary rocks is approximately equal to the mass excess of the topography relative to air. The existence of roots beneath individual plutons is in general agreement with predictions of an Airy model of isostasy and a depth of compensation that is within the crust rather than at the Moho. In addition, a middle crust compensation depth is compatible with the origin of the granites by heating and melting of metasedimentary rocks and with data from experimental rock mechanics which suggest that at the melting temperature and pressure of granite formation, deformation is likely to be plastic and controlled by glide along dislocations. During pluton emplacement the middle crust would, therefore, have acted as a mechanically weak layer, effectively decoupling the topography from any support it might otherwise have received from the lower crust and/or upper mantle

The Permian Cornubian granite batholith, SW England; Part 1: Field, structural, and petrological constraints

This is the author accepted manuscript. The final version is available from the Geological Society of America via the DOI in this recordThe Permian Cornubian granite batholith (295−275 Ma) in SW England includes seven major plutons and numerous smaller stocks extending for ∼250 km from the Isles of Scilly in the WSW to Dartmoor in the ENE. The granites are peraluminous and classified as crustal melt S-type, predominantly two-mica granites, and biotite or tourmaline monzo- and syenogranites, with subordinate minor topaz granite and lithium mica granite. The granites and their host rocks are pervasively mineralized with tin (cassiterite), tungsten (wolframite, ferberite), copper (chalcopyrite, chalcocite, bornite), arsenic (arsenopyrite), and zinc (sphalerite) mineralized lodes. Quartz-muscovite selvedges (greisen-bordered) also contain enrichment of lithophile elements such as boron (tourmaline), fluorine (fluorite), and lithium (lithium-micas such as lepidolite and zinnwaldite). They are derived from both muscovite and biotite dehydration melting of pelitic-psammitic rocks and intruded from a common source along the length of the batholith. Pressure estimates from andalusite and cordierite-bearing hornfels in the contact metamorphic aureole (150 ± 100 MPa) show that the granites intruded to 3 km depth. Cupolas around the Land’s End and Tregonning granites show aplite-pegmatite dikes and tourmaline + quartz + muscovite veins (greisen) that are frequently mineralized. Synchronous intrusions of lamprophyre dikes suggest an additional heat source for crustal melting may have been from underplating of alkaline magmas. The lack of significant erosion means that the source region is not exposed. In an accompanying paper (Part 2; Watts et al., 2024), gravity modeling reveals possible solutions for the shape and depth of the granite and the structure of the lower crust. We present a new model for the Land’s End, Tregonning, and Carnmenellis granites showing a mid-crustal source composed of amphibolite facies migmatites bounded by prominent seismic reflectors, with upward expanding dikes feeding inter-connected granite laccoliths that show inflated cupolas with shallow contact metamorphism. The Cornubian granites intruded >90 m.y. after obduction of the Lizard ophiolite complex, and after Upper Devonian−Carboniferous Variscan compressional, and later extensional, deformation of the surrounding Devonian country rocks. Comparisons are made between the Cornubian batholith and the Patagonian batholith in Chile, the Himalayan leucogranites, and the Baltoro granite batholith along the Karakoram range in northern Pakistan

Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome.

The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regulator genes. Emerging evidence suggests that Polycomb complexes act through controlling spatial genome organization. We show that PRC1 functions as a master regulator of mouse ESC genome architecture by organizing genes in three-dimensional interaction networks. The strongest spatial network is composed of the four Hox gene clusters and early developmental transcription factor genes, the majority of which contact poised enhancers. Removal of Polycomb repression leads to disruption of promoter-promoter contacts in the Hox gene network. In contrast, promoter-enhancer contacts are maintained in the absence of Polycomb repression, with accompanying widespread acquisition of active chromatin signatures at network enhancers and pronounced transcriptional upregulation of network genes. Thus, PRC1 physically constrains developmental transcription factor genes and their enhancers in a silenced but poised spatial network. We propose that the selective release of genes from this spatial network underlies cell fate specification during early embryonic development

Beyond the hippocampus and the SVZ : adult neurogenesis throughout the brain

202011 bcrcVersion of RecordSelf-fundedPublishe