69 research outputs found
Correlations Between Charge Ordering and Local Magnetic Fields in Overdoped YBaCuO
Zero-field muon spin relaxation (ZF-SR) measurements were undertaken on
under- and overdoped samples of superconducting YBaCuO to
determine the origin of the weak static magnetism recently reported in this
system. The temperature dependence of the muon spin relaxation rate in
overdoped crystals displays an unusual behavior in the superconducting state. A
comparison to the results of NQR and lattice structure experiments on highly
doped samples provides compelling evidence for strong coupling of charge, spin
and structural inhomogeneities.Comment: 4 pages, 4 figures, new data, new figures and modified tex
Resonance peak in underdoped cuprates
The magnetic susceptibility measured in neutron scattering experiments in
underdoped YBaCuO is interpreted based on the self-consistent
solution of the t-J model of a Cu-O plane. The calculations reproduce correctly
the frequency and momentum dependencies of the susceptibility and its variation
with doping and temperature in the normal and superconducting states. This
allows us to interpret the maximum in the frequency dependence -- the resonance
peak -- as a manifestation of the excitation branch of localized Cu spins and
to relate the frequency of the maximum to the size of the spin gap. The
low-frequency shoulder well resolved in the susceptibility of superconducting
crystals is connected with a pronounced maximum in the damping of the spin
excitations. This maximum is caused by intense quasiparticle peaks in the hole
spectral function for momenta near the Fermi surface and by the nesting.Comment: 9 pages, 6 figure
Gutzwiller-Correlated Wave Functions: Application to Ferromagnetic Nickel
Ferromagnetic Nickel is the most celebrated iron group metal with pronounced
discrepancies between the experimental electronic properties and predictions of
density functional theories. In this work, we show in detail that the recently
developed multi-band Gutzwiller theory provides a very good description of the
quasi-particle band structure of nickel. We obtain the correct exchange
splittings and we reproduce the experimental Fermi-surface topology. The
correct (111)-direction of the magnetic easy axis and the right order of
magnitude of the magnetic anisotropy are found. Our theory also reproduces the
experimentally observed change of the Fermi-surface topology when the magnetic
moment is oriented along the (001)-axis. In addition to the numerical study, we
give an analytical derivation for a much larger class of variational
wave-functions than in previous investigations. In particular, we cover cases
of superconductivity in multi-band lattice systems.Comment: 35 pages, 3 figure
Muon spin relaxation studies of incommensurate magnetism and superconductivity in stage-4 LaCuO and LaSrCuO
This paper reports muon spin relaxation (MuSR) measurements of two single
crystals of the title high-Tc cuprate systems where static incommensurate
magnetism and superconductivity coexist. By zero-field MuSR measurements and
subsequent analyses with simulations, we show that (1) the maximum ordered Cu
moment size (0.36 Bohr magneton) and local spin structure are identical to
those in prototypical stripe spin systems with the 1/8 hole concentration; (2)
the static magnetism is confined to less than a half of the volume of the
sample, and (3) regions with static magnetism form nano-scale islands with the
size comparable to the in-plane superconducting coherence length. By
transverse-field MuSR measurements, we show that Tc of these systems is related
to the superfluid density, in the same way as observed in cuprate systems
without static magnetism. We discuss a heuristic model involving percolation of
these nanoscale islands with static magnetism as a possible picture to
reconcile heterogeneity found by the present MuSR study and long-range spin
correlations found by neutron scattering.Comment: 19 pages, 15 figures, submitted to Phys. Rev. B. E-mail:
[email protected]
Competing orders in a magnetic field: spin and charge order in the cuprate superconductors
We describe two-dimensional quantum spin fluctuations in a superconducting
Abrikosov flux lattice induced by a magnetic field applied to a doped Mott
insulator. Complete numerical solutions of a self-consistent large N theory
provide detailed information on the phase diagram and on the spatial structure
of the dynamic spin spectrum. Our results apply to phases with and without
long-range spin density wave order and to the magnetic quantum critical point
separating these phases. We discuss the relationship of our results to a number
of recent neutron scattering measurements on the cuprate superconductors in the
presence of an applied field. We compute the pinning of static charge order by
the vortex cores in the `spin gap' phase where the spin order remains
dynamically fluctuating, and argue that these results apply to recent scanning
tunnelling microscopy (STM) measurements. We show that with a single typical
set of values for the coupling constants, our model describes the field
dependence of the elastic neutron scattering intensities, the absence of
satellite Bragg peaks associated with the vortex lattice in existing neutron
scattering observations, and the spatial extent of charge order in STM
observations. We mention implications of our theory for NMR experiments. We
also present a theoretical discussion of more exotic states that can be built
out of the spin and charge order parameters, including spin nematics and phases
with `exciton fractionalization'.Comment: 36 pages, 33 figures; for a popular introduction, see
http://onsager.physics.yale.edu/superflow.html; (v2) Added reference to new
work of Chen and Ting; (v3) reorganized presentation for improved clarity,
and added new appendix on microscopic origin; (v4) final published version
with minor change
Spectral and transport properties of doped Mott-Hubbard systems with incommensurate magnetic order
We present spectral and optical properties of the Hubbard model on a
two-dimensional square lattice using a generalization of dynamical mean-field
theory to magnetic states in finite dimension. The self-energy includes the
effect of spin fluctuations and screening of the Coulomb interaction due to
particle-particle scattering. At half-filling the quasiparticles reduce the
width of the Mott-Hubbard `gap' and have dispersions and spectral weights that
agree remarkably well with quantum Monte Carlo and exact diagonalization
calculations. Away from half-filling we consider incommensurate magnetic order
with a varying local spin direction, and derive the photoemission and optical
spectra. The incommensurate magnetic order leads to a pseudogap which opens at
the Fermi energy and coexists with a large Mott-Hubbard gap. The quasiparticle
states survive in the doped systems, but their dispersion is modified with the
doping and a rigid band picture does not apply. Spectral weight in the optical
conductivity is transferred to lower energies and the Drude weight increases
linearly with increasing doping. We show that incommensurate magnetic order
leads also to mid-gap states in the optical spectra and to decreased scattering
rates in the transport processes, in qualitative agreement with the
experimental observations in doped systems. The gradual disappearence of the
spiral magnetic order and the vanishing pseudogap with increasing temperature
is found to be responsible for the linear resistivity. We discuss the possible
reasons why these results may only partially explain the features observed in
the optical spectra of high temperature superconductors.Comment: 22 pages, 18 figure
Myoclonus in comatose patients with electrographic status epilepticus after cardiac arrest: corresponding EEG patterns, effects of treatment and outcomes
Objective: To clarify the significance of any form of myoclonus in comatose patients after cardiac arrest with rhythmic and periodic EEG patterns (RPPs) by analyzing associations between myoclonus and EEG pattern, response to anti-seizure medication and neurological outcome.Design: Post hoc analysis of the prospective randomized Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resus-citation (TELSTAR) trial.Setting: Eleven ICUs in the Netherlands and Belgium.Patients: One hundred and fifty-seven adult comatose post-cardiac arrest patients with RPPs on continuous EEG monitoring. Interventions: Anti-seizure medication vs no anti-seizure medication in addition to standard care.Measurements and Main Results: Of 157 patients, 98 (63%) had myoclonus at inclusion. Myoclonus was not associated with one specific RPP type. However, myoclonus was associated with a smaller probability of a continuous EEG background pattern (48% in patients with vs 75% without myoclonus, odds ratio (OR) 0.31; 95% confidence interval (CI) 0.16-0.64) and earlier onset of RPPs (24% vs 9% within 24 hours after cardiac arrest, OR 3.86;95% CI 1.64-9.11). Myoclonus was associated with poor outcome at three months, but not invariably so (poor neurological outcome in 96% vs 82%, p = 0.004). Anti-seizure medication did not improve outcome, regardless of myoclonus presence (6% good outcome in the intervention group vs 2% in the control group, OR 0.33; 95% CI 0.03-3.32).Conclusions: Myoclonus in comatose patients after cardiac arrest with RPPs is associated with poor outcome and discontinuous or suppressed EEG. However, presence of myoclonus does not interact with the effects of anti-seizure medication and cannot predict a poor outcome without false positives.Neurological Motor Disorder
Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis
Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analysis (n ~ 43,800) of SK-BMD, identifying 59 loci, collectively explaining 12.5% of the trait variance. Association signals cluster within gene-sets involved in skeletal development and osteoporosis. Among the four novel loci (ZIC1, PRKAR1A, AZIN1/ATP6V1C1, GLRX3), there are factors implicated in intramembranous ossification and as we show, inherent to craniosynostosis processes. Functional follow-up in zebrafish confirms the importance of ZIC1 on cranial suture patterning. Likewise, we observe abnormal cranial bone initiation that culminates in ectopic sutures and reduced BMD in mosaic atp6v1c1 knockouts. Mosaic prkar1a knockouts present asymmetric bone growth and, conversely, elevated BMD. In light of this evidence linking SK-BMD loci to craniofacial abnormalities, our study provides new insight into the pathophysiology, diagnosis and treatment of skeletal diseases. Prevention, Population and Disease management (PrePoD)Public Health and primary car
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease
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