Production of Ac-225 and Application of the Bi-213 Daughter in Cancer Therapy.

Abstract not availableJRC.E-Institute for Transuranium Elements (Karlsruhe

Single-Column Extraction Chromatographic Separation of U, Np, Pu and Am.

Abstract not availableJRC.E-Institute for Transuranium Elements (Karlsruhe

Cyclotron Production of Ac-225 for Targeted Alpha Therapy

The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.JRC.E.5-Nuclear chemistr

Cyclotron Production of Ac-225 for Targeted alpha Therapy.

Abstract not availableJRC.I-Institute for Health and Consumer Protection (Ispra

Cyclotron Production of Ac-225 for Targeted Alpha Therapy

The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.JRC.I.4-Nanotechnology and Molecular Imagin

Development and Validation of a Simple, Rapid and Robust Method for the Chemical Separation of Uranium and Plutonium.

A simple and robust method was developed for the chemical separation of uranium and plutonium from mixed U/Pu/fission product solutions. The method is based on a commercially available resin, UTEVA-spec. It yields pure U and Pu fractions with recoveries superior to 95% respectively, using a single column. The method is simple and robust, allowing a rapid separation with a minimum of secondary waste being created. The method was validated for application in routine analysis of nuclear materials covering a wide range of concentrations and U/Pu ratios.JRC.E-Institute for Transuranium Elements (Karlsruhe

Production of Carrier Free Actinium-225/Bismuth-212 from Thorium-229 for alpha-Immunitherapy.

Abstract not availableJRC.E-Institute for Transuranium Elements (Karlsruhe

Lysine Protection against Bismuth Accumulation in the Kidneys when Using 213-Bi-DTPA-MAB.

Abstract not availableJRC.E-Institute for Transuranium Elements (Karlsruhe

Radiopeptide Therapy with Cholecystokinin(CCK)-B/Gastrin Receptor Ligands Labeled with Auger/Conversion Electron-versus alpha- or Conventional beta Emitters.

Abstract not availableJRC.E-Institute for Transuranium Elements (Karlsruhe

Radiopeptide Therapy with Cholecystokinin-B/Gastrin Receptor Ligands: Dose-Limiting Toxicity and Therapeutic Efficacy of Auger / Conversion Electron (111-In, 140-Nd) vs alpha(213-Bi) or Conventional beta(90-Y, 153-Sm) Emitters.

Abstract not availableJRC.E-Institute for Transuranium Elements (Karlsruhe