Explicit Planning Helps Language Models in Logical Reasoning

Language models have been shown to perform remarkably well on a wide range of natural language processing tasks. In this paper, we propose a novel system that uses language models to perform multi-step logical reasoning. Our system incorporates explicit planning into its inference procedure, thus able to make more informed reasoning decisions at each step by looking ahead into their future effects. In our experiments, our full system significantly outperforms other competing systems. On a multiple-choice question answering task, our system performs competitively compared to GPT-3-davinci despite having only around 1.5B parameters. We conduct several ablation studies to demonstrate that explicit planning plays a crucial role in the system's performance

A Bridge Between Two Worlds: a Cultural Interpretation of Dragonwings

Living in the dual worlds of his life as a Chinese American and in places such as Chinatown, Laurence Yep felt that he was culturally alienated and that he did not have a culture of his own. With the driving wish to find out about Chinese culture―his culture, he finished his best known novel Dragonwings after six years of research on Chinese culture. Based on the true story of Fung Joe Guey, a Chinese American who built and flew an airplane in the Oakland hills in 1909, Dragonwings tells the story of Moon Shadow, who comes to San Francisco to join his unknown father, Windrider, who cherishes the dream of flying. To pursue the dream, Moon Shadow and his father have to move out of Chinatown. After enduring a sea of misunderstanding, cruelty and poverty, Windrider finally realizes his flying dream with the support and aid of his beloved son and his fellowmen, as well as his American friends. Trying to show the process from misinterpretation and misunderstanding to mutual understanding and the possibilities of cultural exchange and cultural fusion between two different cultures, we will discuss how the Chinese culture is rediscovered by a Chinese American and how cultural misunderstanding leads to an unbalanced world and how tolerance and understanding restore the world into a harmonious one. This paper attempts to demonstrate, through the analysis of Dragonwings, the author’s exploration of Chinese culture, cultural exchange and human nature transcending cultural differences. Key words: Dragonwings, Laurence Yep, cultural exchange Abstrait: En vivant dans le monde dual de sa vie comme Américain chinois et aux endroits comme la Cité chinoise, Laurence Yep trouve qu’il était aliéné culturellement et qu’il n’avait pas de culture de sa ville. Avec l’espoir violent à découvrir la culture chinoise----sa culture, il a achevé son roman bien connu Dragon-ailes après une recherche de six années sur la culture chinoise. Basé sur l’histoire vraie de Fung Joe Guey , un Américain Chinois qui a fabriqué et manié un avion dans les Montagnes Oakland en 1909, Dragon-ailes raconte le conte de Ombre de lune, qui vient à San Francisco pour rejoindre son père inconnu , Windrider, qui a le rêve de voler .Poursuivant le rêve, Ombre Lunaire et son père sont obligés de bouger de la Cité chinoise. Après avoir enduré une mer d’incompréhension , de cruauté et de pauvreté, Windrider a finalement réalizé son rêve de voler avec l’aide de son fils et ses compagnons, ainsi que ses amis américains. Essayant de montrer le processus de malinterprétation et de incompréhension à compréhension mutuelle et les possibilités d’échange et de fusion culturels entre deux cultures différentes, nous discuterons comment la culture chinoise est redécouverte par un Américian chinois et comment l’incompréhension culturelle conduit à un monde inégal et comment la tolérance et la compréhension reconstruisent le monde à celui d’harmonique. Ce papier tente de démontrer , à travers l’analyse de Dragon-ailes , l’exploration de l’auteur de la culture chinoise , de l’échange culturel et des différences transcendantes naturelles de la nature humaine. Mots clefs: Dragon-ailes, Laurence Yep, échange culture

Risk Factors in the Patients with Extracranial Carotid Atherosclerosis

There are vascular risk factors known to be associated with stroke. These risk factors have been shown to either directly or indirectly lead to stroke. The risk factors include hypertension (HT), diabetes mellitus (DM), smoking, hyperlipidaemia, ischemic heart disease (IHD) and atrial fibrillation (AF). Studies have shown that carotid atherosclerosis is a cause of stroke. Extracranial carotid atherosclerosis accounts for up to 40% of the ischemic strokes in the Western countries. The latest stroke guidelines recommend the routine use of Ultrasound Carotid Doppler to assess for extracranial carotid artery atherosclerotic diseases (carotid intima media thickness, plaques, carotid stenosis) in these patients. A previous study emphasized the value of carotid ultrasonography in the detection of early extracranial carotid atherosclerosis

{μ-N-[(Diphenyl­phosphino)meth­yl]pyridin-2-amine-κ2 N 1:P}bis­{[2-(2,2′-bipyridin-6-yl)phenyl-κ3 N,N′,C 1]platinum(II)} bis­(perchlorate)

The title compound, [Pt2(C16H11N2)2(C18H17N2P)](ClO4)2, contains two PtII atoms, bridged by an N-[(diphenyl­phosphino)meth­yl]pyridin-2-amine (dppmp) ligand. One Pt atom is coordinated by one P atom from the dppmp ligand, and one C atom and two N atoms from a 6-phenyl-2,2′-bipyridine (pbpy) ligand in a square-planar geometry. The other Pt atom is coordinated by one N atom from the dppmp ligand, and one C atom and two N atoms from another pbpy ligand in a square-planar geometry. There are intra­molecular π–π inter­actions between the pbpy ligands, with a centroid–centroid distance of 3.62 (1) Å between two pyridyl rings. The oxygen atoms of both perchlorate anions are disordered, each over two different positions [occupanicies 0.49 (3)/0.51 (3) and 0.48 (2)/0.52 (2)]

Galectin-3- Mediated Transdifferentiation of Pulmonary Artery Endothelial Cells Contributes to Hypoxic Pulmonary Vascular Remodeling

Background/Aims: Vascular muscularity is a key event in vessel remodeling during pulmonary artery hypertension (PAH). Endothelial-mesenchymal transdifferentiation (EndMT) has been increasingly reported to play a role in disease occurrence. Galectin-3, a carbohydrate-binding protein regulates cell proliferation, differentiation, migration and neovascularization. However, whether galectin-3 controls endothelial cell transdifferentiation during the development of PAH is unknown. Methods: Rats were exposed to normoxic or hypoxic conditions (fraction of inspired O2 0.10) for 21 d to establish PAH models. Hemodynamic changes were evaluated through surgery of the right jugular vein and ultrasound biomicroscopy inviVue. And vessel pathological alterations were detected by H&E staining. Galectin-3 (Gal-3)-induced pulmonary artery endothelium cell (PAEC) dynamic alterations were measured by MTT assays, Cell immunofluorescence, Flow cytometry, Real-time PCR and Western blot. Results: Our study demonstrated that Gal-3 was expressed in hypoxic pulmonary vascular adventitia and intima. The increased Gal-3 expression was responsible for hypoxic vessel remodeling and PAH development in vivo. Gal-3 was found to inhibit cell proliferation and apoptosis in cultured endothelial cells. Meanwhile endothelial cell morphology was altered and exhibited smooth muscle-like cell features as demonstrated by the expression of α-SMA after Gal-3 treatment. Gal-3 activated Jagged1/Notch1 pathways and induced MyoD and SRF. When MyoD or SRF were silenced with siRNAs, Gal-3-initiated transdifferentiation in endothelial cells was blocked as indicated by a lack of α-SMA. Conclusion: These results suggest that Gal-3 induces PAECs to acquire an α-SMA phenotype via a transdifferentiation process which depends on the activation of Jagged1/Notch1 pathways that mediate MyoD and SRF expression

The Aβ Containing Brain Extracts Having Different Effects in Alzheimer’s Disease Transgenic Caenorhabditis elegans and Mice

Background: The deposition of β-sheet rich amyloid in senile plaques is a pathological hallmark of Alzheimer’s disease (AD), which is thought to cause neuronal dysfunction. Previous studies have strongly implicated that intracerebral infusion of brain extract containing aggregated β-amyloid (Aβ) is able to induce cerebral amyloidosis thus causing neuronal damage and clinical abnormalities in rodents and nonhuman primates, which are reminiscent of a prion-like mechanism. Prion disease has been documented in cases of prion-contaminated food consumption.Methods: We investigated whether cerebral transmission of Aβ was possible via oral administration of Aβ-rich brain extract in non-susceptible and susceptible host mice by immunohistochemistry, western blotting and behavior tests. Also brain extracts were supplied to AD transgenic Caenorhabditis elegans, and paralysis curve were conducted, following detection of Aβ amyloid. RNA sequencing of nematodes was applied then inhibitors for relevant dysregulated genes were used in the paralysis induction.Results: The oral treatment of AD brain extract or normal brain extract neither aggravated nor mitigated the Aβ load, glial activation or the abnormal behaviors in recipient Amyloid precursor protein/presenilin 1 (APP/PS1) mice. Whereas, a significant improvement of AD pathology was detected in worms treated with Aβ-rich or normal brain extracts, which was attributable to the heat-sensitive components of brain extracts. Transcriptome sequencing of CL4176 nematodes suggested that brain extracts could delay worm paralysis through multiple pathways, including ubiquitin mediated proteolysis and Transforming growth factor β (TGF-β) signaling pathway. Inhibitors of the ubiquitin proteasome system and the TGF-β signaling pathway significantly blocked the suppressive effects of brain extracts on worm paralysis.Conclusions: Our results suggest that systemic transmissible mechanisms of prion proteopathy may not apply to β amyloid, at least in terms of oral administration. However, brain extracts strongly ameliorated AD pathology in AD transgenic nematodes partially through TGF-β signaling pathway and ubiquitin mediated proteolysis, which indicated that some natural endogenous components in the mammalian tissues could resist Aβ toxicity