Wireless monitoring of liver hemodynamics in vivo

Liver transplants have their highest technical failure rate in the first two weeks following surgery. Currently, there are limited devices for continuous, real-time monitoring of the graft. In this work, a three wavelengths system is presented that combines near-infrared spectroscopy and photoplethysmography with a processing method that can uniquely measure and separate the venous and arterial oxygen contributions. This strategy allows for the quantification of tissue oxygen consumption used to study hepatic metabolic activity and to relate it to tissue stress. The sensor is battery operated and communicates wirelessly with a data acquisition computer which provides the possibility of implantation provided sufficient miniaturization. In two in vivo porcine studies, the sensor tracked perfusion changes in hepatic tissue during vascular occlusions with a root mean square error (RMSE) of 0.135 mL/min/g of tissue. We show the possibility of using the pulsatile wave to measure the arterial oxygen saturation similar to pulse oximetry. The signal is also used to extract the venous oxygen saturation from the direct current (DC) levels. Arterial and venous oxygen saturation changes were measured with an RMSE of 2.19% and 1.39% respectively when no vascular occlusions were induced. This error increased to 2.82% and 3.83% when vascular occlusions were induced during hypoxia. These errors are similar to the resolution of a commercial oximetry catheter used as a reference. This work is the first realization of a wireless optical sensor for continuous monitoring of hepatic hemodynamics. © 2014 Akl et al

Reducing Reoffending Research Project: Action Learning Set 3

The ambition of ALS1 and ALS2 had been to showcase the integrated criminal justice practice operating in The Hague (Netherlands) and Knowsley (Merseyside, UK) respectively. With ALS3 the emphasis shifted to explore the capacity to import some of the examples of good/best practice - taken from Dutch and UK partners - into the Italian context. The Life Change Programme (LCP), developed and currently delivered by MALS Merseyside, has been previously identified as mode of working that can be introduced into the work the European Research Institute currently undertakes. However, a key objective of ALS3 was to raise collective awareness of the operation of the criminal justice system in Italy more generally so that delegates can make more realistic assessments of the potential for integrating different and innovative ways of working to reducing reoffending

Reducing Reoffending Research Project: Action Learning Set 5

The penultimate Action Learning Set (ALS) saw a return to The Hague and a city where the first gathering of partners was staged. With the venues of the 5th and 6th ALSs switched to allow the Life Change Programme in Italy the opportunity to fully bed itself in and recruit more participants the emphasis here was about allowing partners to delve deeper into the workings of the Safety House structure(s) in The Hague and provide opportunities for shared learning. With this objective in mind the emphasis was on showcasing Safety House projects that seek to reduce reoffending behaviour

Reducing Reoffending Research Project: Action Learning Set 4

The agenda for Action Learning Set 4 was ambitious, forward-facing, and embedded in sharing and thinking about working practice. It started with an observation of the LifeChange Programme and ended with members of the Dutch delegation meeting with local Police and Security officials discussing approaches to tackling football violence and religious extremism, and in-between there was much detailed reflection on progress. With the project closer to its conclusion now than its commencement, as the day developed the emphasis really shifted towards the project outcomes, measures of impact, and the roles of partners in playing their part(s) in achieving these end goal

European Reoffending Research Project: Action Learning Set 2

The objectives of the Knowsley based ALS 2 were threefold; firstly, for partners to reflect on emergent questions form the previous ALS; secondly, for hosts Knowsley to showcase the work of local criminal justice partners; and, thirdly to focus specifically on the (potential and real) use of mentoring and of the work of MALS (Mentoring Achieve Learn Support) Merseyside in particular. As a consequence the morning was taken up by presentations from representatives of each international partner - ensuring delegates were able to get a clearer sense of the respective offending profiles of the three areas - whilst a series of detailed insights from representatives from Knowsley Metropolitan Borough Council, Merseyside Police, and Merseyside Probation Trust identified some of the partnership and innovative work to tackle re-offending being conducted in the Knowsley area. Electronic copies of these presentations are available and paper copies were produced for those in attendance, for this reason the commentary provided in this report (section 2) will summarise their key themes and identify the issues raised from the floor. The third objective of the ALS – to explore the potential of mentoring schemes – shaped the afternoon session(s) and emerged as the key theme to define the day’s learning/discussion. A presentation by the MALS team outlining their organisation’s origins, aims, and ambition(s) bolstered by drawing upon case studies to highlight tangible challenges in the delivery of mentoring provision gave the ALS real focus. In summarising the MALS presentation and drawing together the different strands of the wide ranging and stimulating questions/discussions that followed, section 3 of the report provides delegates with a snapshot of working practice to explore, reflect upon, and engage with. The presentation gave a real momentum to the discussion groups that followed that had as their aims the potential for exporting the MALS model to International partners and of then exploring the dilemmas and challenges raised by using such innovative interventions. Section 4 analyses and orders the emergent themes from these discussions and Section 5 teases out the very explicit questions for partners to confront. By way of conclusion section 6 of the report maps out some of the themes that have emerged from the first two ALSs that our next ALS will need to engage with

European Reducing Reoffending Project: Action Learning Set 6

The final Action Learning Set (ALS) took place in Turin and allowed the Life Change Programme in Italy to showcase its progress to date, particularly in terms of its partnership working and efforts to create sustainable employment opportunities for ex-offenders within a difficult economic environment. This challenging context is made tougher by societal reluctance to give ex-offenders a second chance in the form of job opportunities for example

European Reoffending Research Project: Action Learning Set 1

The overarching aim of this project is to evaluate processes and procedures implemented to reduce reoffending rates through coordinated targeting of resources at offenders with the greatest criminogenic needs. Within this remit, the role of the Action Learning Sets is to increase mutual understanding and cooperation between the trans-national partners (Knowsley MBC, Merseyside Police, Municipality of the Hague NL, European Research Institute of Turino, Italy and MALS Merseyside) by testing different methods for reducing reoffending and reflecting on lessons learned. This first Action Learning Set was crucial to understanding the baselines, or starting points, of the partners in the European Reoffending Research Project. The research team explained the project methodology and each partner then provided an overview of their current contexts and provisions. These are summarised below

Working Together to Reduce Reoffending: Reducing Reoffending Project 2012-2015

The stated principal aim of the ‘Reducing Reoffending in the EU’ project since its inception has been To prevent crime by reducing reoffending rates through coordinated targeting of resources at those offenders whose criminogenic needs require additional intervention and support. The two objectives partners have been working towards to delivering during the 3-year life cycle of the project are: • To utilise a multi-agency approach to improve offenders self-worth, self-motivation, desire to change and willingness to engage, and increase their opportunities to receive education, training and employment opportunities. • To develop the Life Change programme with the voluntary sector, to assist with mentoring, re-integration through access to the 7 pathways out of reoffending, and improving public confidence that reoffending rates are reducing. The structure of the project was designed to prevent crime and reduce reoffending across Europe by developing a transnational partnership with Knowsley MBC, The Hague and the ERI. At its core has been the development and delivery of the innovative Life Change Programme (LCP), a programme developed by using best practice and drawing on evidence of effectiveness (see accompanying training guide for more detail on course content). The structured programme of work that ran through the project placed the emphasis on Knowsley based partners to design and pilot the LCP in Year 1 and to develop the training guidance (based on the pilot) that would ensure the course had a legacy of intervention work. Finally the Italian partners at the ERI would then deliver a pilot of the LCP in year 2 to test the validity of the programme and to explore the capacity for policy transfer. Throughout the lifecycle of the project the Action Learning Sets provided a forum for the methodology and tools for strategically fighting crime to be shared between partners to evaluate best practice in crime prevention. The role of the Dutch partners from The Hague was to contribute their experiences of operating the Safety House (as a model of good practice) to help share and develop learning throughout the whole of the project. What made the original project ambitions innovative was: • Use of offender rehabilitation as the primary purpose of crime prevention. • An emphasis on offender rehabilitation within the community post-release. • A multi-agency, multi-disciplinary approach covering various types of offender and crime. • A structure of pilot, best-practice exchange, peer review, and production of a portable model of working

Hall effect and transmission electron microscopy of epitaxial MnSi thin films

We present Hall effect measurements on MnSi/Si(111) epilayers and find an anomalous Hall contribution that is significantly smaller than in bulk crystals, which enables the observation of an additional contribution to the anomalous signal previously overlooked in MnSi. Our measurements indicate the signal is not due to skyrmions in MnSi thin films, which are absent in out-of-plane fields, but rather are the result of scattering from the cone phase. The absence of magnetic contrast in the transmission electron microscopy (TEM) measurements are consistent with this interpretation. We provide a method to model TEM images of skyrmions lattices to determine the conditions necessary for their observation in other B20 epilayers with an anisotropy that is favourable to their formation.T.L.M. and M.N.W. acknowledge support from NSERC and the support of the Canada Foundation for Innovation, the Atlantic Innovation Fund, and other partners which fund the Facilities for Materials Characterization, managed by the Institute for Research in Materials. Work done by J.C.L. was funded by the Royal Society. The work of F.N.R. was supported by RFBR, research project No. 14-02-31012.This is the accepted manuscript of a paper published in Physical Review B (SA Meynell, MN Wilson, JC Loudon, A Spitzig, FN Rybakov, MB Johnson, TL Monchesky, Physical Review B 2014 90, 224419)