9 research outputs found
Antiplasmodial activities of some products from Turreanthus africanus (Meliaceae)
Get PDFWe investigated the antiplasmodial activity of some pure compounds of Turreanthus africanus (Meliaceae), a plant that is used in traditional medicine to treat malaria in Southwest Cameroon. A phytochemical analysis of the methylene chloride: methanol (1:1) extract of the seeds of the plant yielded seven compounds. Four of them, which were oils, were subjected to in vitro bioassays on Plasmodium falciparum F 32, chloroquine sensitive strain. Compound 1 (16-oxolabda-8 (17), 12(E)-dien-15-oic acid), showed the highest antiplasmodial activity, two others (methyl-14,15-epoxylabda-8 (17), 12(E)-diene-16-oate, and turreanin A), had moderate activity and one was inactive. These findings are consistent with the use of T. africanus in the traditional treatment of P. falciparum malaria. African Journal of Health Sciences Vol. 13 (1-2) 2008: pp. 32-3
Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux
No full textStructurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum
No full textEvaluation of macrofilaricidal and microfilaricidal activities against Onchocerca ochengi and cytotoxicity of some synthesized azo compounds containing thiophene backbone
No full textIn vitro and in vivo analysis of the anti-plasmodial activity of ethanol extract of Phyllanthus nivosus W. Bull leaf
No full textCameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification
No full textThe potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019
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