27 research outputs found
Effects of temperature in juvenile seabass (Dicentrarchus labrax L.) biomarker responses and behaviour: implications for environmental monitoring
The effects of temperature on European seabass
(Dicentrarchus labrax L.) juveniles were investigated using
a 30-day bioassay carried out at 18 and 25 °C in laboratory
conditions. A multiparameter approach was applied including
fish swimming velocity and several biochemical parameters
involved in important physiological functions. Fish exposed for
four weeks to 25 °C showed a decreased swimming capacity,
concomitant with increased oxidative stress (increased catalase
and glutathione peroxidase activities) and damage (increased
lipid peroxidation levels), increased activity of an enzyme
involved in energy production through the aerobic pathway
(isocitrate dehydrogenase) and increased activities of brain and
muscle cholinesterases (neurotransmission) compared to fish
kept at 18 °C. Globally, these findings indicate that basic
functions, essential for juvenile seabass surviving and well
performing in the wild, such as predation, predator avoidance,
neurofunction and ability to face chemical stress may be compromised
with increasing water temperature. This may be of
particular concern if D. labrax recruitment phase in northwest
European estuaries and coastal areas happens gradually inmore
warm environments as a consequence of global warming.
Considering that the selected endpoints are generally applied
in monitoring studies with different species, these findings also
highlight the need of more research, including interdisciplinary
and multiparameter approaches, on the impacts of temperature
on marine species, and stress the importance of considering
scenarios of temperature increase in environmental monitoring
and in marine ecological risk assessment
The financial burden of destination left ventricular assist device therapy: Who and when?
Management of end-stage heart failure: a perspective on the Arab Gulf states
The ever expanding epidemic of end-stage heart failure represents one of the greatest challenges of modern cardiovascular medicine. With medical treatments hampered by significant limitations, physicians caring for patients with advanced heart disease have turned to cardiac transplantation and durable mechanical circulatory assist devices as definitive therapies. These advanced therapeutic modalities are not widely available outside the United States and Europe, but nevertheless offer enormous potential for patients in the Arab Gulf suffering from end-stage heart failure. This review will discuss the management of end-stage heart failure in the Gulf States, with an emphasis on therapies best utilized within a framework of regional cooperation and coordination
Disturbance of oxidant/antioxidant status and impairment on fillet fatty acid profiles in Brycon amazonicus subjected to acute heat stress
The epigenetic landscape of transgenerational acclimation to ocean warming
Epigenetic inheritance is a potential mechanism by which the environment in one generation can influence the performance of future generations1. Rapid climate change threatens the survival of many organisms; however, recent studies show that some species can adjust to climate-related stress when both parents and their offspring experience the same environmental change2,3. Whether such transgenerational acclimation could have an epigenetic basis is unknown. Here, by sequencing the liver genome, methylomes and transcriptomes of the coral reef fish, Acanthochromis polyacanthus, exposed to current day (+0 °C) or future ocean temperatures (+3 °C) for one generation, two generations and incrementally across generations, we identified 2,467 differentially methylated regions (DMRs) and 1,870 associated genes that respond to higher temperatures within and between generations. Of these genes, 193 were significantly correlated to the transgenerationally acclimating phenotypic trait, aerobic scope, with functions in insulin response, energy homeostasis, mitochondrial activity, oxygen consumption and angiogenesis. These genes may therefore play a key role in restoring performance across generations in fish exposed to increased temperatures associated with climate change. Our study is the first to demonstrate a possible association between DNA methylation and transgenerational acclimation to climate change in a vertebrate