2 research outputs found
The relationship between dietary fat intake and risk of colorectal cancer: Evidence from the combined analysis of 13 case-control studies
The objective of this study was to examine the effects of the intake of
dietary fat upon colorectal cancer risk in a combined analysis of data
from 13 case-control studies previously conducted in populations with
differing colorectal cancer rates and dietary practices. Original data
records for 5,287 cases of colorectal cancer and 10,470 controls were
combined. Logistic regression analysis was used to estimate odds ratios
(OR) for intakes of total energy, total fat and its components, and
cholesterol. Positive associations with energy intake were observed for
11 of the 13 studies. However, there was little, if any, evidence of any
energy-independent effect of either total fat with ORs of 1.00, 0.95,
1.01, 1.02, and 0.92 for quintiles of residuals of total fat intake (P
trend = 0.67) or for saturated fat with ORs of 1.00, 1.08, 1.06, 1.21,
and 1.06 (P trend = 0.39). The analysis suggests that, among these
case-control studies, there is no energy-independent association between
dietary fat intake and risk of colorectal cancer. It also suggests that
simple substitution of fat by other sources of calories is unlikely to
reduce meaningfully the risk of colorectal cancer