PROPERTIES, MICROSTRUCTURE AND HOT DEFORMATIONBEHAVIOUR OF DIFFERENT Al-Zn-Mg (Zr) ALLOYS.

Two alloys based on Al-Zn-Mg (Zr), were characterized from microstructural and mechanical points of view. Hot tensile tests and torsion test on as-cast samples were performed. Deformed samples exhibit some static recrystallization (SRX) more evident in the alloy without Zr. As-cast alloys hot deformed by tension exhibits considerable cavitation that increases with temperature (T) . The analysis of this phenomena on 7000 as cast alloy has shown that cavity growth is mainly controlled by plastic strain both at 250°C and 400°C even if grain boundary sliding (GBS) contributes to enhance the fraction of cavities at the highest T . Cavitation is reduced if the alloy is solutionized before deformation

Working up policy : the use of specific disease exemplars in formulating general principles governing childhood genetic testing.

Non-therapeutic genetic testing in childhood presents a “myriad of ethical questions”; questions which are discussed and resolved in professional policy and position statements. In this paper we consider an underdiscussed but strongly influential feature of policy-making, the role of selective case and exemplar in the production of general recommendations. Our analysis, in the tradition of rhetoric and argumentation, examines the predominate use of three particular disease exemplar (Huntington’s disease, Tay-Sachs disease and sickle cell disease) to argue for or against particular genetic tests (predictive testing and testing for carrier status). We discuss the influence these choices have on the type and strength of subsequent recommendations. We argue that there are lessons to be drawn about how genetic diseases are conceptualised and we caution against the geneticisation of medical policy making