<b style="">Herbal remedies for acne</b>

328-334Acne represents a significant challenge to dermatologists because of its prevalence, complexity and range of clinical expression. It is the single most common skin disease affecting 85% of teenage boys and 80% of teenage girls and can continue throughout adulthood. Treatment of acne with topical and systemic allopathic medicines results in mild to severe side effects. Hence, herbs and herbal preparations play a significant role as alternative line of treatment. This article describes the commonly used herbs in the treatment of acn

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

Gout is the most common arthritic disease in human but was long neglected and therapeutic options are not satisfying. However, with the recent approval of the urate transporter inhibitor lesinurad, gout treatment has experienced a major innovation. Here we show that lesinurad possesses considerable modulatory potency on peroxisome proliferator-activated receptor γ (PPARγ). Since gout has a strong association with metabolic diseases such as type 2 diabetes, this side-activity appears as very valuable contributing factor to the clinical efficacy profile of lesinurad. Importantly, despite robustly activating PPARγ in vitro, lesinurad lacked adipogenic activity, which seems due to differential coactivator recruitment and is characterized as selective PPARγ modulator (sPPARγM)