2,388 research outputs found
Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation
Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after transplantation. With the median effect analysis of Chou and Kahan for quantitative drug interactions, substantial therapeutic synergism was demonstrated between FK506 and nontoxic doses of MĪZ (2.5, 5, and 10 mg/kg/day) or AZA (5, 30, and 45 mg/kg/day), which was particularly evident with the lowest dose MIZ (2.5 mg/kg/day). When FK506 was used in combination with MIZ or AZA but not with RS, the maximum effect (peak median graft survival) was enhanced significantly from 15 days (MIZ alone) to 26 days (P<0.05), and from 19 days (AZA alone) to 32 days (P<0.0l). In contrast, RS interacted with FK506 no more than additively. Although RS was the most powerful single antimetabolite, the best overall survival was obtained by combining AZA and FK506. The addition of FK506 did not significantly increase the percent mortality and LD50 of the antimetabolites. © 1994 by Williams and Wilkins
Origin of Tc Enhancement Induced by Doping Yttrium and Hydrogen into LaFeAsO-based Superconductors: 57Fe, 75As, 139La, and 1H-NMR Studies
We report our extensive 57Fe-, 75As-, 139La-, and 1H-NMR studies of
La_{0.8}Y_{0.2}FeAsO_{1-y} (La_{0.8}Y_{0.2}1111) and
LaFeAsO_{1-y}H_{x}(La1111H), where doping yttrium (Y) and hydrogen (H) into
optimally doped LaFeAsO_{1-y} (La1111(OPT)) increases T_c=28 K to 34 and 32 K,
respectively. In the superconducting (SC) state, the measurements of
nuclear-spin lattice-relaxation rate 1/T_1 have revealed in terms of a multiple
fully gapped s_\pm-wave model that the SC gap and T_c in La_{0.8}Y_{0.2}1111
become larger than those in La1111(OPT) without any change in doping level. In
La1111H, the SC gap and T_c also increase slightly even though a decrease in
carrier density and some disorders are significantly introduced. As a
consequence, we suggest that the optimization of both the structural parameters
and the carrier doping level to fill up the bands is crucial for increasing T_c
among these La1111-based compounds through the optimization of the Fermi
surface topology.Comment: 4 pages, 4 figures, 1 table, to be published in J. Phys. Soc. Jpn,
Vol. 79, No. 1
Isolated osteochondroma near the mandibular angle
ArticleINTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY. 36(3): 274-275 (2007)journal articl
Numerical Study on Split Coil-shaped HTS Bulks to Improve the Field Homogeneity for Compact NMR Relaxometry Magnets
AbstractWe have been developing a new compact NMR magnet using stacked HTS bulks. In this pa er, in order to improve the trapped magnetic field homogeneity and to obtain the enlarged sample space of HTS bulk magnet for compact NMR relaxometry, the HTS bulk magnet with 10mm gap length in the center region of HTS bulk magnet (we call it “split coil-shaped THS bulks”) were proposed and studied as the functions of size and shape of HTS bulk using 3D FEM based electromagnetic analysis. The improved field homogeneity was obtained using notch coil shaped HTS bulk configuration and the field compensation by attached the coil instated of the bulks
High-pressure structural investigation of several zircon-type orthovanadates
Room temperature angle-dispersive x-ray diffraction measurements on
zircon-type EuVO4, LuVO4, and ScVO4 were performed up to 27 GPa. In the three
compounds we found evidence of a pressure-induced structural phase
transformation from zircon to a scheelite-type structure. The onset of the
transition is near 8 GPa, but the transition is sluggish and the low- and
high-pressure phases coexist in a pressure range of about 10 GPa. In EuVO4 and
LuVO4 a second transition to a M-fergusonite-type phase was found near 21 GPa.
The equations of state for the zircon and scheelite phases are also determined.
Among the three studied compounds, we found that ScVO4 is less compressible
than EuVO4 and LuVO4, being the most incompressible orthovanadate studied to
date. The sequence of structural transitions and compressibilities are
discussed in comparison with other zircon-type oxides.Comment: 34 pages, 2 Tables, 11 Figure
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