Backcasting energy saving and CO2 emission reductions by using feebates system in Japan

After the Kyoto Conference (COP3), the Japanese transport sector was required to reduce carbon dioxide (CO2) emissions by 16% by 2010. The Japanese government has decided to improve the fuel economy standard in 2010 by improving it by an average of 22.8%. However, Japanese consumers tend to prefer heavier passenger cars such as four-wheel drive or recreational vehicles. Because of the difficult target of COP3, environmental policy should involve not only automotive technologies but also non-technical measures. Since Japanese vehicle taxes are expensive compared to other OECD countries, we would like to introduce the “feebate”, a word composed from “fee” and “rebate”, as a “Green Tax” at the acquisition stage. The feebate system charges a fee for less fuel-efficient vehicles and refunds for vehicles more fuel efficient than the fuel efficiency standard. This system is a market based alternative by fuel efficiency standards so that it can be tax neutral. Acquisition tax does not affect to environmental sustainability. Since social marginal cost has increased more and more, it is not always realistic to impose all the costs at the motoring tax level. The feebate system could partially share the social marginal cost and might mitigate the rebound effect at the motoring stage. We use the data set from 1995-2001 on fuel efficiency by vehicle type and the fuel efficiency standards of 1995. The contribution of this paper will be to propose a combination of feebate rate and CO2 emission reduction by vehicle gross weight group.

cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells

老化T細胞が自己免疫病や慢性炎症疾患を引き起こすメカニズムを解明 --老化関連疾患克服への新しいアプローチ--. 京都大学プレスリリース. 2022-09-22.With age, senescence-associated (SA) CD4+ T cells that are refractory to T cell receptor (TCR) stimulation are increased along with spontaneous germinal center (Spt-GC) development prone to autoantibody production. We demonstrate that CD153 and its receptor CD30 are expressed in SA-T and Spt-GC B cells, respectively, and deficiency of either CD153 or CD30 results in the compromised increase of both cell types. CD153 engagement on SA-T cells upon TCR stimulation causes association of CD153 with the TCR/CD3 complex and restores TCR signaling, whereas CD30 engagement on GC B cells induces their expansion. Administration of an anti-CD153 antibody blocking the interaction with CD30 suppresses the increase in both SA-T and Spt-GC B cells with age and ameliorates lupus in lupus-prone mice. These results suggest that the molecular interaction of CD153 and CD30 plays a central role in the reciprocal activation of SA-T and Spt-GC B cells, leading to immunosenescent phenotypes and autoimmunity

The Role of Radiotherapy for Thymic Carcinoma

Objective: The aim of this study is to evaluate retrospectively the role of radiotherapy for thymic carcinoma. Methods: Between 1973 and 1998, 14 patients with thymic carcinoma were treated at Gunma Prefectural Cancer Center. Two patients who had hematogenous metastasis were excluded from this study, therefore 12 patients were analyzed. The Masaoka staging system was used; four patients were diagnosed with stage III disease and eight patients with stage IV disease. The pathological subtype according to the World Health Organization histological criteria for thymic tumors was squamous cell carcinoma (low-grade histology) in six cases and undifferentiated carcinoma (high-grade histology) in six. Ten patients underwent thoracotomy, and two patients underwent excisional biopsy without thoracotomy. Ten patients (83%) received radiotherapy as a curative intent, and the median dose was 60 Gy. Systemic chemotherapy was administered to four patients (33%), and the majority (75%) of the regimens contained cisplatin. Results: The 3-year overall survival rate was 25%. Histological subtype (low-grade versus highgrade), surgical resection (complete versus incomplete), radiotherapy and chemotherapy were evaluated as prognostic factors in a univariate analysis. Low-grade histology and complete resection were good prognostic factors, although these were not statistically significant. Patients who received radiotherapy had a better outcome than those who did not. The major sites of recurrence were the pleura and pericardium. Recurrence within the radiation field was observed in one of seven patients in whom failure patterns could be evaluated. Conclusion: Complete resection is mandatory if possible. Radiotherapy plays an important role in treating thymic carcinoma in terms of reducing local recurrence and prolonging survival time. Establishment of an innovative treatment protocol that includes chemotherapy is necessary to control intrathoracic relapse and distant metastasis

Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization

Brd4 is a mammalian protein that contains a double bromodomain. It binds to chromatin and regulates cell cycle progression at multiple stages. By immunopurification and mass spectrometry, we identified a Rap GTPase-activating protein (GAP), signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4. SPA-1 localizes to the cytoplasm and to a lesser degree in the nucleus, while Brd4 resides in the nucleus. Bifluorescence complementation revealed that Brd4 and SPA-1 interact with each other in the nucleus of living cells. Supporting the functional importance of the interaction, Brd4 enhanced Rap GAP activity of SPA-1. Furthermore ectopic expression of SPA-1 and Brd4 redirected subcellular localization of the partner and disrupted normal cell cycle progression. These effects were, however, reversed by coexpression of the two proteins, indicating that a proper balance between Brd4 and SPA-1 in G(2) is required for cell division. This work reveals a novel link between Brd4 and a GTPase-dependent mitogenic signaling pathway