X-ray spectral evolution in the ultraluminous X-ray source M33 X-8

The bright ultraluminous X-ray source (ULX), M33 X-8, has been observed several times by XMM–Newton, providing us with a rare opportunity to ‘flux bin’ the spectral data and search for changes in the average X-ray spectrum with flux level. The aggregated X-ray spectra appear unlike standard sub-Eddington accretion state spectra which, alongside the lack of discernible variability at any energy, argues strongly against conventional two-component, sub-Eddington models. Although the lack of variability could be consistent with disc-dominated spectra, sub-Eddington disc models are not sufficiently broad to explain the observed spectra. Fits with a ∼ Eddington accretion rate slim disc model are acceptable, but the fits show that the temperature decreases with flux, contrary to expectations, and this is accompanied by the appearance of a harder tail to the spectrum. Applying a suitable two-component model reveals that the disc becomes cooler and less advection dominated as the X-ray flux increases, and this is allied to the emergence of an optically thick Comptonization medium. We present a scenario in which this is explained by the onset of a radiatively driven wind from the innermost regions of the accretion disc, as M33 X-8 exceeds the Eddington limit. Furthermore, we argue that the direct evolution of this spectrum with increasing luminosity (and hence radiation pressure) leads naturally to the two-component spectra seen in more luminous ULXs

The ultraluminous state revisited : fractional variability and spectral shape as diagnostics of super-Eddington accretion

Although we are nearing a consensus that most ultraluminous X-ray sources (ULXs) below 1041 erg s−1 represent stellar mass black holes accreting in a super-Eddington ‘ultraluminous’ accretion state, little is yet established of the physics of this extreme accretion mode. Here, we use a combined X-ray spectral and timing analysis of an XMM–Newton sample of ULXs to investigate this new accretion regime. We start by suggesting an empirical classification scheme that separates ULXs into three classes based on the spectral morphologies observed by Gladstone et al.: a singly peaked broadened disc class, and two-component hard ultraluminous and soft ultraluminous regimes, with the spectra of the latter two classes dominated by the harder and softer component, respectively. We find that at the lowest luminosities (LX < 3 × 1039 erg s−1) the ULX population is dominated by sources with broadened disc spectra, whilst ULXs with two-component spectra are seen almost exclusively at higher luminosities, suggestive of a distinction between ∼Eddington and super-Eddington accretion modes. We find high levels of fractional variability are limited to ULXs with soft ultraluminous spectra, and a couple of the broadened disc sources. Furthermore, the variability in these sources is strongest at high energies, suggesting it originates in the harder of the two spectral components. We argue that these properties are consistent with current models of super-Eddington emission, where a massive radiatively driven wind forms a funnel-like geometry around the central regions of the accretion flow. As the wind provides the soft spectral component this suggests that inclination is the key determinant in the observed two-component X-ray spectra, which is very strongly supported by the variability results if this originates due to clumpy material at the edge of the wind intermittently obscuring our line-of-sight to the spectrally hard central regions of the ULX. The pattern of spectral variability with luminosity in two ULXs that straddle the hard/soft ultraluminous regime boundary is consistent with the wind increasing at higher accretion rates, and thus narrowing the opening angle of the funnel. Hence, this work suggests that most ULXs can be explained as stellar mass black holes accreting at and above the Eddington limit, with their observed characteristics dominated by two variables: accretion rate and inclination

A spectral-timing model for ULXs in the supercritical regime

Ultraluminous X-ray sources (ULXs) with luminosities lying between ∼3 × 1039 and 2 × 1040 erg s−1 represent a contentious sample of objects as their brightness, together with a lack of unambiguous mass estimates for the vast majority of the central objects, leads to a degenerate scenario where the accretor could be a stellar remnant (black hole or neutron star) or intermediate-mass black hole (IMBH). Recent, high-quality observations imply that the presence of IMBHs in the majority of these objects is unlikely unless the accretion flow somehow deviates strongly from expectation based on objects with known masses. On the other hand, physically motivated models for supercritical inflows can re-create the observed X-ray spectra and their evolution, although have been lacking a robust explanation for their variability properties. In this paper, we include the effect of a partially inhomogeneous wind that imprints variability on to the X-ray emission via two distinct methods. The model is heavily dependent on both inclination to the line of sight and mass accretion rate, resulting in a series of qualitative and semiquantitative predictions. We study the time-averaged spectra and variability of a sample of well-observed ULXs, finding that the source behaviours can be explained by our model in both individual cases as well as across the entire sample, specifically in the trend of hardness-variability power. We present the covariance spectra for these sources for the first time, which shed light on the correlated variability and issues associated with modelling broad ULX spectra

The ultraluminous X-ray source NGC 5643 ULX1: a large stellar mass black hole accreting at super-Eddington rates?

A sub-set of the brightest ultraluminous X-ray sources (ULXs), with X-ray luminosities well above 1040 erg s−1, typically have energy spectra which can be well described as hard power laws, and short-term variability in excess of ∼10 per cent. This combination of properties suggests that these ULXs may be some of the best candidates to host intermediate-mass black holes (IMBHs), which would be accreting at sub-Eddington rates in the hard state seen in Galactic X-ray binaries. In this work, we present a temporal and spectral analysis of all of the available XMM–Newton data from one such ULX, the previously poorly studied 2XMM J143242.1−440939, located in NGC 5643. We report that its high-quality EPIC spectra can be better described by a broad, thermal component, such as an advection-dominated disc or an optically thick Comptonizing corona. In addition, we find a hint of a marginal change in the short-term variability which does not appear to be clearly related to the source unabsorbed luminosity. We discuss the implications of these results, excluding the possibility that the source may be host an IMBH in a low state, and favouring an interpretation in terms of super-Eddington accretion on to a black hole of stellar origin. The properties of NGC 5643 ULX1 allow us to associate this source to the population of the hard/ultraluminous ULX class

A γ-β frequency transition generated by inter-areal communication in the hippocampus in vitro

Gamma oscillations are generated in area CA3 of the hippocampus both in vitro and in vivo (Fisahn et al., 1998; Csicsvari et al., 2003). Here we present experimental and network simulation data to elucidate the mechanism of the generation of CA3-driven gamma and beta oscillations in area CA1. (1) The frequency of area CA1 output generated by gamma input from area CA3 was dependent on the degree of recruitment of CA1 principal cells. Passive involvement of area CA1 principal cells resulted in a gamma frequency oscillation. Active involvement of CA1 principal cells transformed this gamma oscillation into one at beta frequencies. (2) This beta oscillation in area CA1 was dependent on CA1 recurrent excitation. (3) It was also dependent on the temporal relationship between feedforward excitation of CA1 interneurons (by CA3 output) and feedback excitation of CA1 interneurons (by CA1 output). That is, the network beta oscillation in area CA1 depended on doublet firing of certain interneurons driven by area CA3. (4) The interneuron doublet rate during beta corresponded to whether or not dendrites are oriented horizontally or vertically: Interneurons with vertically oriented dendrites (eg. basket cells and - to a lesser extent - bistratified cells, all receiving input from CA3) fired considerably more doublets than interneurons with horizontally oriented dendrites (horizontal alveus cells or olm cells) which are not contacted by area CA3 and hardly ever fired doublets during beta. Taken together the findings demonstrate that different interneurons can serve different purposes during a given network oscillation, that single interneuron subtypes can mediate multiple network frequencies, and that the frequency of output from a cortical region serves to signal the degree of principal cell recruitment

A γ-β frequency transition generated by inter-areal communication in the hippocampus in vitro

Gamma oscillations are generated in area CA3 of the hippocampus both in vitro and in vivo (Fisahn et al., 1998; Csicsvari et al., 2003). Here we present experimental and network simulation data to elucidate the mechanism of the generation of CA3-driven gamma and beta oscillations in area CA1. (1) The frequency of area CA1 output generated by gamma input from area CA3 was dependent on the degree of recruitment of CA1 principal cells. Passive involvement of area CA1 principal cells resulted in a gamma frequency oscillation. Active involvement of CA1 principal cells transformed this gamma oscillation into one at beta frequencies. (2) This beta oscillation in area CA1 was dependent on CA1 recurrent excitation. (3) It was also dependent on the temporal relationship between feedforward excitation of CA1 interneurons (by CA3 output) and feedback excitation of CA1 interneurons (by CA1 output). That is, the network beta oscillation in area CA1 depended on doublet firing of certain interneurons driven by area CA3. (4) The interneuron doublet rate during beta corresponded to whether or not dendrites are oriented horizontally or vertically: Interneurons with vertically oriented dendrites (eg. basket cells and - to a lesser extent - bistratified cells, all receiving input from CA3) fired considerably more doublets than interneurons with horizontally oriented dendrites (horizontal alveus cells or olm cells) which are not contacted by area CA3 and hardly ever fired doublets during beta. Taken together the findings demonstrate that different interneurons can serve different purposes during a given network oscillation, that single interneuron subtypes can mediate multiple network frequencies, and that the frequency of output from a cortical region serves to signal the degree of principal cell recruitment

Lack of association between KIR and HLA-C type and susceptibility to idiopathic bronchiectasis

SummaryIntroductionIdiopathic bronchiectasis is a poorly defined disease characterised by persistent inflammation, infection and progressive lung damage. Natural killer (NK) cells provide a major defense against infection, through the interaction of their surface receptors, including the activating and inhibitory killer immunoglobulin-like receptors (KIR), and human leukocyte antigens (HLA) class I molecules. Homozygosity for HLA-C has been shown in a single study to confer increased genetic susceptibility to idiopathic bronchiectasis. We aimed to assess whether the KIR and HLA repertoire, alone or in combination, may influence the risk of developing idiopathic bronchiectasis, in an independent replication study.MethodsIn this prospective, observational, case-control association study, 79 idiopathic bronchiectasis patients diagnosed following extensive aetiological investigation were compared with 98 anonymous, healthy, age, sex and ethnically-matched controls attending blood donor sessions in the same geographical location. DNA extraction was performed according to standardised techniques. Determination of presence or absence of KIR genes was performed by a sequence specific oligonucleotide probe method. Allele frequencies for the proposed KIR, HLA-B and HLA-C risk alleles both individually and in combinations were compared.ResultsWe found no significant differences in allele frequency between the idiopathic bronchiectasis and control samples, whether considering HLA-C group homozygosity alone or in combination with the KIR type.DiscussionOur results do not show an association between HLA-C and KIR and therefore do not confirm previous positive findings. This may be explained by the lower frequency of HLA-C1 group homozygosity in the control population of the previous study (27.2%), compared to 42.3% in our study, which is consistent with the genetic profiling of control groups across the UK. The previous positive association study may therefore have been driven by an anomalous control group. Further larger prospective multicentre replication studies are needed to determine if an association exists

Urinary arsenic profiles reveal exposures to inorganic arsenic from private drinking water supplies in Cornwall, UK

Private water supplies (PWS) in Cornwall, South West England exceeded the current WHO guidance value and UK prescribed concentration or value (PCV) for arsenic of 10 μg/L in 5% of properties surveyed (n = 497). In this follow-up study, the first of its kind in the UK, volunteers (n = 207) from 127 households who used their PWS for drinking, provided urine and drinking water samples for total As determination by inductively coupled plasma mass spectrometry (ICP-MS) and urinary As speciation by high performance liquid chromatography ICP-MS (HPLC-ICP-MS). Arsenic concentrations exceeding 10 μg/L were found in the PWS of 10% of the volunteers. Unadjusted total urinary As concentrations were poorly correlated (Spearman’s ρ = 0.36 (P < 0.001)) with PWS As largely due to the use of spot urine samples and the dominance of arsenobetaine (AB) from seafood sources. However, the osmolality adjusted sum, U-AsIMM, of urinary inorganic As species, arsenite (AsIII) and arsenate (AsV), and their metabolites, methylarsonate (MA) and dimethylarsinate (DMA), was found to strongly correlate (Spearman’s ρ: 0.62 (P < 0.001)) with PWS As, indicating private water supplies as the dominant source of inorganic As exposure in the study population of PWS users