Early warning system based on data mining to identify crime patterns

The analysis of criminal information is critical for the purpose of preventing the occurrence of offenses, so the crime records committed in the past are analyzed including perpetrators. The main objective was to identify crime patterns in the city of Bogota, Colombia, supported using Early Warning System based on data mining (CRISP-DM method). The research results show the identification of 12 different criminal profiles demonstrating that the Early Warning System is applicable since it managed to significantly reduce the time devoted to the processes of registering complaints and searching for criminal profiles.Universidad Peruana de Ciencias Aplicadas, Universidad de la Costa, Corporación Universitaria Latinoamericana

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.

Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection. The mature antibody, CH103, neutralized approximately 55% of HIV-1 isolates, and its co-crystal structure with the HIV-1 envelope protein gp120 revealed a new loop-based mechanism of CD4-binding-site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the unmutated common ancestor of the CH103 lineage avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data determine the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies, and provide insights into strategies to elicit similar antibodies by vaccination