30 research outputs found
Protection against live rotavirus challenge in mice induced by parenteral and mucosal delivery of VP6 subunit rotavirus vaccine
Live oral rotavirus (RV) vaccines are part of
routine childhood immunization but are associated with
adverse effects, particularly intussusception. We have developed
a non-live combined RV – norovirus (NoV) vaccine
candidate consisting of human RV inner-capsid rVP6
protein and NoV virus-like particles. To determine the
effect of delivery route on induction of VP6-specific protective
immunity, BALB/c mice were administered a vaccine
containing RV rVP6 intramuscularly, intranasally or a
combination of both, and challenged with murine RV. At
least 65 % protection against RV shedding was observed
regardless of delivery route. The levels of post-challenge
serum VP6-specific IgA titers correlated with protection