Diffusional Kurtosis and Diffusion Tensor Imaging Reveal Different Time-Sensitive Stroke-Induced Microstructural Changes

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Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention‐deficit hyperactivity disorder: A diffusional kurtosis imaging study

Purpose To investigate non-Gaussian water diffusion using diffusional kurtosis imaging (DKI) to assess age effects on gray matter (GM) and white matter (WM) microstructural changes in the prefrontal cortex (PFC) of adolescents with attention-deficit hyperactivity disorder (ADHD) compared to typically developing controls (TDC). Materials and Methods In this preliminary cross-sectional study, T1-weighted magnetization-prepared rapid gradient echo (MPRAGE) and DKI images were acquired at 3T from TDC (n = 13) and adolescents with ADHD (n = 12). Regression analysis of the PFC region of interest (ROI) was conducted. Results TDC show a significant kurtosis increase of WM microstructural complexity from 12 to 18 years of age, particularly in the radial direction, whereas WM microstructure in ADHD is stagnant in both the axial and radial directions. In ADHD, GM microstructure also lacked a significant age-related increase in complexity as seen in TDC; only kurtosis measures were able to detect this difference. Conclusion These findings support the prevailing theory that ADHD is a disorder affecting frontostriatal WM. Our study is the first to directly quantify an aberrant age-related trajectory in ADHD within GM microstructure, suggesting that the assessment of non-Gaussian directional diffusion using DKI provides more sensitive and complementary information about tissue microstructural changes than conventional diffusion imaging methods

Diffusional kurtosis detects cortical demyelination in the cuprizone mouse model

The cuprizone mouse model is a well characterized animal model of demyelination. Recently, cortical demyelination has also been observed. Diffusion tensor imaging (DTI) studies have demonstrated the pathology of the corpus callosum (CC) in cuprizone mouse model, but no cortical diffusion changes have been reported. Diffusional Kurtosis Imaging (DKI) quantifies the non-Gaussian behavior of water diffusion, contributing additional information beyond that provided by DTI. Here we report, for the first time, DKI changes in the cortex of mice with demyelination induced by cuprizone, demonstrating the significant advantage of microstructural characterization using DKI, especially for abnormalities in grey matter

Diffusional kurtosis imaging detects age-related grey matter changes in the normal mouse brain

Since the transition from young to aged adult during the normal aging process leads to changes in grey matter morphology, characterizing the age-related diffusion patterns in the rodent brain is important for interpreting and differentiating the changes associated with pathological process in rodents’ models of neurodegenerative diseases. Diffusional Kurtosis Imaging (DKI) quantifies the non-Gaussian behavior of water diffusion, contributing additional information beyond that provided by diffusion tensor imaging. Here we report that the DKI can characterize the age-related microstructural changes in the cortex and sub-cortical regions in the normal mouse brain