10,164 research outputs found
Recursive Numerical Evaluation of the Cumulative Bivariate Normal Distribution
We propose an algorithm for evaluation of the cumulative bivariate normal
distribution, building upon Marsaglia's ideas for evaluation of the cumulative
univariate normal distribution. The algorithm is mathematically transparent,
delivers competitive performance and can easily be extended to arbitrary
precision.Comment: 12 pages, 1 figur
A Study of Energy and Locality Effects using Space-filling Curves
The cost of energy is becoming an increasingly important driver for the
operating cost of HPC systems, adding yet another facet to the challenge of
producing efficient code. In this paper, we investigate the energy implications
of trading computation for locality using Hilbert and Morton space-filling
curves with dense matrix-matrix multiplication. The advantage of these curves
is that they exhibit an inherent tiling effect without requiring specific
architecture tuning. By accessing the matrices in the order determined by the
space-filling curves, we can trade computation for locality. The index
computation overhead of the Morton curve is found to be balanced against its
locality and energy efficiency, while the overhead of the Hilbert curve
outweighs its improvements on our test system.Comment: Proceedings of the 2014 IEEE International Parallel & Distributed
Processing Symposium Workshops (IPDPSW
Functional maturation during bovine granulopoiesis
Granulocytic precursor cells undergo morphologic changes in the nucleus and the cytoplasm during the process of granulopoiesis, which takes place in the bone marrow. These changes are associated with the development of stage-specific proteins necessary for the highly specialized roles of polymorphonuclear leukocytes in phagocytosis, bacterial killing, and in mediating the inflammatory process. The objective of the current study was to sequence the various events that occur upon functional development of granulocytic bone marrow cells in the bovine species.
Cells were obtained from the bone marrow of clinically healthy cows and separated into different stages of maturation using density gradient centrifugation. Three cellular fractions were obtained that were enriched for either early immature, late immature or mature granulocytic cells. Functions and receptor expressions assessed in the three maturation stages were: Fc-IgG(2) receptor and CD11b expression, phagocytosis of Escherichia coli, respiratory burst activity, and cellular myeloperoxidase activity. Immature cells expressed already Fc-IgG(2) receptor and CD11b on their cytoplasma membrane. Phagocytic ability was acquired in the myelocytic stage, but only the more mature forms were readily capable of phagocytosis. Promyelocytes, myelo-cytes and metamyelocytes showed no respiratory burst activity. Only band and segmented cells produced reactive oxygen species. Myeloperoxidase was present at all stages of maturity. Thus, each of the maturation stages was characterized by a selective expression of one or more functions and receptors. Therefore, sequential biochemical maturation is postulated during bovine granulopoiesis
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