How institutional quality, and energy production sources, affect the environmental sustainability of bri countries: A comparison of different income groups.

Institutions and energy production sources shape environmental policies and practices. Institutions establish frameworks for renewable energy and enforce environmental protection measures. Conventional energy sources cause pollution and climate change, while green energy sources have lower environmental impacts. In this study we analyzed how quality institutions, along with different types of energy production sources affect the quality of environment in 101 countries that are part of the BRI, a global development project. We used a statistical method called panel quantile regression to analyze data from 2000 to 2020. We found that producing energy from renewable sources, such as wind and solar, reduces CO2 emissions by 0.003% in BRI countries. However, producing energy from non-renewable sources, such as gas and coal, harms the environment more in high-income and middle-income countries. We also found that having better institutional quality reduces CO2 emissions by 3.421%, 2.710%, and 0.006% in different groups of BRI countries. This means that having stronger and fairer institutions can help protect the environment by limiting the use of non-renewable energy sources and encouraging the use of renewable ones. Our study suggests that improving institutional quality is a key factor for achieving green energy and environmental sustainability in BRI countries

The impact of masticatory dysfunction caused by occlusal disharmony on cognitive function

As the world’s population ages, age-related cognitive decline and dementia are becoming important challenges for geriatric care. Despite the ongoing search for solutions to address cognitive decline, effective interventions have not yet been established. There is increasing evidence from clinical, epidemiological, and animal studies that masticatory dysfunction due to occlusal disharmony is a risk factor for cognitive decline and an increased incidence of dementia. The mechanisms may involve altered nutritional intake, decreased cerebral blood flow, chronic stress, and hippocampal morphological function. These findings suggest that maintaining and adequately restoring the entire masticatory system has a positive impact for the prevention of cognitive decline

Two-stage mixotrophic cultivation for enhancing the biomass and lipid productivity of Chlorella vulgaris

Abstract This study proposes a two-stage mixotrophic process for cultivating Chlorella vulgaris. Heterotrophic growth is the dominant step in Phase I (to increase microalgal biomass) and photoautotrophic growth occurs in Phase II (to improve biomass concentration and lipid production). The results show that the addition of the low-cost antioxidant sodium erythorbate (8 g L−1) significantly accelerates the growth of microalgae in the first stage with air aeration. Furthermore, a higher CO2 fixation rate was obtained in the second stage (at least 344.32 mg CO2 L−1 day−1) with 10% CO2 aeration. This approximately corresponds to an increase of 177% over simple photoautotrophic cultivation with 10% CO2 aeration during the whole period. The two-stage cultivation strategy achieved a maximum C. vulgaris biomass concentration of 3.45 g L−1 and lipid productivity of 43.70 mg L−1 day−1, which are 1.85 and 1.64 times those arising due to simple photoautotrophy, respectively. Moreover, an analysis of the product’s fatty acid profile indicates that C. vulgaris might be an ideal candidate for two-stage mixotrophic cultivation of a renewable biomass for use in biodiesel applications. Another interesting point to note from the study is that it is an insufficiency of N and CO2 that probably limits the further growth of C. vulgaris

Flame Retardancy of High-Density Polyethylene Composites with P,N-Doped Cellulose Fibrils

To derive P,N-doped cellulose fibrils, phosphoric acid and aqueous ammonia were placed in a one-pot reaction, and the phosphate groups and ammonium phosphates were successfully introduced into the cellulose surface. The obtained P,N-doped cellulose fibrils with high liberation were thereafter incorporated into a high-density polyethylene (HDPE) matrix to improve the flame retardancy of HDPE composites, and they had a significant improvement on flame retardancy of HDPE composites. In particular, 7 wt % P,N-doped cellulose fibrils considerably reduced the average and peak heat release rate (HRR) by 29.6% and 72.9%, respectively, and increased the limited oxygen index (LOI) by 30.5%. The presence of phosphate groups and ammonium phosphates within P,N-doped cellulose fibrils was found to promote the thermal degradation of HDPE composites at a lower temperature (i.e., 240 °C). The released acid catalyzed the dehydration of cellulose to form an aromatic carbonaceous structure with a higher crystalline orientation, which improves the flame retardancy of HDPE composites

Retrieval of the Leaf Area Index from MODIS Top-of-Atmosphere Reflectance Data Using a Neural Network Supported by Simulation Data

The leaf area index (LAI), a key parameter used to characterize the structure and function of the vegetation canopy, is crucial to simulations of the carbon, nitrogen, and water cycles of Earth’s system. In this paper, a neural network (NN) method coupled with vegetation canopy and atmospheric radiative transfer (RT) simulations is proposed to realize LAI retrieval without prior data support and complex atmospheric corrections. The look-up table (LUT) of the top-of-atmosphere (TOA) reflectance and associated input variables was simulated by 6S (6S simulation) based on the top-of-canopy (TOC) reflectance LUT simulated by PROSAIL. This was then used to train the NN to obtain the LAI inversion model. This method has been successfully applied to MODIS L1B data (MOD021KM), and the LAI retrieval of the vegetation canopy was realized. The estimated LAI was compared with the MODIS LAI (MOD15A2H) using mid-latitude summer data from 2000 to 2017 in the DIRECT 2.0 ground database. The experiments indicated that the LAI retrieved by the TOA reflectance (r = 0.7852, RMSE = 0.5191) was not much different from the LAI retrieved by the TOC reflectance (r = 0.8063, RMSE = 0.7669), and the accuracy was better than the MODIS LAI (r = 0.7607, RMSE = 0.8239), which proves the feasibility of this method

Retrieval of the Leaf Area Index from MODIS Top-of-Atmosphere Reflectance Data Using a Neural Network Supported by Simulation Data

The leaf area index (LAI), a key parameter used to characterize the structure and function of the vegetation canopy, is crucial to simulations of the carbon, nitrogen, and water cycles of Earth’s system. In this paper, a neural network (NN) method coupled with vegetation canopy and atmospheric radiative transfer (RT) simulations is proposed to realize LAI retrieval without prior data support and complex atmospheric corrections. The look-up table (LUT) of the top-of-atmosphere (TOA) reflectance and associated input variables was simulated by 6S (6S simulation) based on the top-of-canopy (TOC) reflectance LUT simulated by PROSAIL. This was then used to train the NN to obtain the LAI inversion model. This method has been successfully applied to MODIS L1B data (MOD021KM), and the LAI retrieval of the vegetation canopy was realized. The estimated LAI was compared with the MODIS LAI (MOD15A2H) using mid-latitude summer data from 2000 to 2017 in the DIRECT 2.0 ground database. The experiments indicated that the LAI retrieved by the TOA reflectance (r = 0.7852, RMSE = 0.5191) was not much different from the LAI retrieved by the TOC reflectance (r = 0.8063, RMSE = 0.7669), and the accuracy was better than the MODIS LAI (r = 0.7607, RMSE = 0.8239), which proves the feasibility of this method

Docosahexaenoic Acid-Loaded Nanostructured Lipid Carriers for the Treatment of Peri-Implantitis in Rats

Being the most common cause of implant failure, peri-implantitis is defined as a pathological condition associated with the occurrence of peri-implant plaque, characterized by peri-implant mucosal inflammation and progressive loss of the supporting bone tissue attributed to the persistence of pro-inflammatory cytokines. Docosahexaenoic acid (DHA), which is a type of omega-3 polyunsaturated fatty acid, is generally used for the treatment of many inflammatory diseases. However, a suitable form for dosing and its therapeutic effect on peri-implantitis remain unclear. In this study, a novel nanostructured lipid carrier (NLC) loaded with squalene and DHA was fabricated (DHA-loaded NLC). The encapsulation efficiency and drug loading efficiency values of the DHA-loaded NLC were 78.13% ± 1.85% and 28.09% ± 0.48%, respectively. The release of DHA was gradual and steady until 144 h. In addition, the free-radical-scavenging rate of DHA-loaded NLC (0.57 ± 0.03) was much higher than that of sole DHA (0.17 ± 0.003). By inhibiting nuclear factor-κB p65 nuclear translocation, DHA-loaded NLC prevented the activation of nuclear factor-κB downstream inflammatory pathways and exerted anti-inflammatory effects on macrophages. Moreover, DHA-loaded NLC showed better effects on preventing alveolar bone resorption of rat peri-implantitis model than sole DHA. Hence, DHA-loaded NLC enhanced the anti-inflammatory bioavailability of DHA, offering a novel approach for the treatment of peri-implantitis

Sulforaphane-Mediated Nrf2 Activation Prevents Radiation-Induced Skin Injury through Inhibiting the Oxidative-Stress-Activated DNA Damage and NLRP3 Inflammasome

This article mainly observed the protective effect of sulforaphane (SFN) on radiation-induced skin injury (RISI). In addition, we will discuss the mechanism of SFN’s protection on RISI. The RISI model was established by the irradiation of the left thigh under intravenous anesthesia. Thirty-two C57/BL6 mice were randomly divided into control group (CON), SFN group, irradiation (IR) group, and IR plus SFN (IR/SFN) group. At eight weeks after irradiation, the morphological changes of mouse skin tissues were detected by H&E staining. Then, the oxidative stress and inflammatory response indexes in mouse skin tissues, as well as the expression of Nrf2 and its downstream antioxidant genes, were evaluated by ELISA, real-time PCR, and Western blotting. The H&E staining showed the hyperplasia of fibrous tissue in the mouse dermis and hypodermis of the IR group. Western blotting and ELISA results showed that the inflammasome of NLRP3, caspase-1, and IL-1β, as well as oxidative stress damage indicators ROS, 4-HNE, and 3-NT, in the skin tissues of mice in the IR group were significantly higher than those in the control group (p < 0.05). However, the above pathological changes declined sharply after SFN treatment (p < 0.05). In addition, the expressions of Nrf2 and its regulated antioxidant enzymes, including CAT and HO-1, were higher in the skin tissues of SFN and IR/SFN groups, but lower in the control and IR groups (p < 0.05). SFN may be able to suppress the oxidative stress by upregulating the expression and function of Nrf2, and subsequently inhibiting the activation of NLRP3 inflammasome and DNA damage, so as to prevent and alleviate the RISI

China’s Rural-Urban Care Gap Shrank For Chronic Disease Patients, But Inequities Persist

Daniel Reidpath - ORCID: 0000-0002-8796-0420 https://orcid.org/0000-0002-8796-0420Item is not available in this repository.Reducing the gap in health outcomes between rural and urban areas in China has been a focus of the central government’s health reform efforts since 2002. Drawing on national survey data from 2003 and 2008, this paper analyzes changes in the rural-urban gap for patients with chronic diseases. Overall, there were substantial improvements at the national level in insurance coverage and the use of hospital services for both urban and rural residents with chronic diseases. There was also an overall reduction in the rural-urban gap in the use of inpatient services. But the gains were uneven. For example, although rural Chinese with chronic disease could more easily start inpatient treatment in 2008 than they could in 2003, because of the higher hospital copayments required under insurance coverage for rural citizens, they were more than twice as likely to drop out of treatment as were Chinese in urban areas. The strongest evidence of the narrowing of the rural-urban gap came from central China, while the evidence is mixed for western and eastern China. Our analysis suggests that different approaches will be required to narrow the rural-urban health service gap in different regions of China.https://doi.org/10.1377/hlthaff.2009.098929pubpub1

Inhibitory Effects of Myriocin on Non-Enzymatic Glycation of Bovine Serum Albumin

Advanced glycation end products (AGEs) are the compounds produced by non-enzymatic glycation of proteins, which are involved in diabetic-related complications. To investigate the potential anti-glycation activity of Myriocin (Myr), a fungal metabolite of Cordyceps, the effect of Myr on the formation of AGEs resulted from the glycation of bovine serum albumin (BSA) and the interaction between Myr and BSA were studied by multiple spectroscopic techniques and computational simulations. We found that Myr inhibited the formation of AGEs at the end stage of glycation reaction and exhibited strong anti-fibrillation activity. Spectroscopic analysis revealed that Myr quenched the fluorescence of BSA in a static process, with the possible formation of a complex (approximate molar ratio of 1:1). The binding between BSA and Myr mainly depended on van der Waals interaction, hydrophobic interactions and hydrogen bond. The synchronous fluorescence and UV-visible (UV-vis) spectra results indicated that the conformation of BSA altered in the presence of Myr. The fluorescent probe displacement experiments and molecular docking suggested that Myr primarily bound to binding site 1 (subdomain IIA) of BSA. These findings demonstrate that Myr is a potential anti-glycation agent and provide a theoretical basis for the further functional research of Myr in the prevention and treatment of AGEs-related diseases