International Dispute Resolution: International Commercial Arbitration: 2018-19

Course number: 3007D.03https://digitalcommons.osgoode.yorku.ca/casebooks/1103/thumbnail.jp

New Constraints on Supersymmetry Using Neutrino Telescopes

We demonstrate that megaton-mass neutrino telescopes are able to observe the signal from long-lived particles beyond the Standard Model, in particular the stau, the supersymmetric partner of the tau lepton. Its signature is an excess of charged particle tracks with horizontal arrival directions and energy deposits between 0.1 and 1 TeV inside the detector. We exploit this previously-overlooked signature to search for stau particles in the publicly available IceCube data. The data shows no evidence of physics beyond the Standard Model. We derive a new lower limit on the stau mass of $320$ GeV (95\% C.L.) and estimate that this new approach, when applied to the full data set available to the IceCube collaboration, will reach world-leading sensitivity to the stau mass ($m_{\tilde{\tau}}=450\,\mathrm{GeV}$)

Searching for Dark Matter Annihilation with IceCube and P-ONE

We present a new search for weakly interacting massive particles utilizing ten years of public IceCube data, setting more stringent bounds than previous IceCube analysis on massive dark matter to neutrino annihilation. We also predict the future potential of the new neutrino observatory, P-ONE, showing that it may even exceed the sensitivities of gamma-ray searches by about 1-2 orders of magnitude in 1-10 TeV regions. This analysis considers the diffuse dark matter self-annihilation to neutrinos via direct and indirect channels, from the galactic dark matter halo and extra-galactic sources. We also predict that P-ONE will be capable of pushing these bounds further than IceCube, even reaching the thermal relic abundance utilizing a galactic center search for extended run-time.Comment: We included some details about the statistical analysi

Les villes minières québécoises et le développement local : le cas de la ville de Matagami

L’intérêt économique pour le Nord québécois a conduit à la création de plusieurs collectivités. En effet, l’immense réserve de ressources naturelles de ce territoire a attiré nombreux investisseurs. Investisseurs qui, autrefois, assumaient la responsabilité du développement des collectivités. Aujourd’hui, il en est tout autre : les collectivités sont responsables de leur propre développement. Elles doivent donc composer avec les spécificités territoriales, les contraintes démographiques et l’étroitesse de la base économique pour organiser et planifier leur avenir. Dans une économie de plus en plus globale et compétitive, les défis de développement sont grands. Comment ces communautés peuvent-elles se redéfinir et opérer une transition de leur base économique ? Est-ce possible d’envisager un type de développement opposé à celui qu’elles connaissent depuis toujours ? Ainsi, l’objectif de la recherche est d’étudier l’implication et la participation d’une communauté nordique québécoise, en l’occurrence celle de la ville minière de Matagami, à son propre développement. Le but étant d’examiner si une mobilisation et une prise en charge sont possibles au sein de cette collectivité pour en assurer sa pérennité. L’étude est orientée autour de deux caractéristiques reconnues pour favoriser le développement endogène : l’ancrage au territoire et le capital social. Cette étude de cas permet d’explorer comment la trajectoire et le type de développement imposés aux collectivités minières influencent la création du tissu social et l’appartenance au territoire. L’analyse des résultats a permis l’identification des différents rapports au territoire des résidents de la ville de Matagami ainsi qu’une meilleure compréhension de l’influence du type de développement boom and bust sur l’attachement au territoire et sur le développement du capital social

The natural furanone (5<i>Z</i>)-4-bromo-5-(bromomethylene)-3-butyl-2(5<i>H</i>)-furanone disrupts quorum sensing-regulated gene expression in <i>Vibrio harveyi</i> by decreasing the DNA-binding activity of the transcriptional regulator protein luxR

This study aimed at getting a deeper insight in the molecular mechanism by which the natural furanone (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)- furanone disrupts quorum sensing in Vibrio harveyi. Bioluminescence experiments with signal molecule receptor double mutants revealed that the furanone blocks all three channels of the V. harveyi quorum sensing system. In further experiments using mutants with mutations in the quorum sensing signal transduction pathway, the compound was found to block quorum sensing-regulated bioluminescence by interacting with a component located downstream of the Hfq protein. Furthermore, reverse transcriptase real-time polymerase chain reaction with specific primers showed that there was no effect of the furanone on luxRVh mRNA levels in wild-type V. harveyi cells. In contrast, mobility shift assays showed that in the presence of the furanone, significantly lower levels of the LuxRVh response regulator protein were able to bind to its target promoter sequences in wild-type V. harveyi. Finally, tests with purified LuxRVh protein also showed less shifts with furanone-treated LuxRVh, whereas the LuxRVh concentration was found not to be altered by the furanone (as determined by SDS-PAGE). Therefore, our data indicate that the furanone blocks quorum sensing in V. harveyi by rendering the quorum sensing master regulator protein LuxRVh unable to bind to the promoter sequences of quorum sensing-regulated genes

Dissociative-like Spells in a Child With Neurofibromatosis (type 1)

Neurofibromatosis, type 1, (NF1) is a common neurocutaneous disorder of childhood. Little is known about the psychiatric aspects of the condition. We present the case of a 10-year-old male with NF1 and complex spells. For two years he had been experiencing self-limited paroxysms of auditory and visual hallucination, assaultiveness, excited undressing, and amnesia. The spells have been refractory to multiple treatments, including antipsychotic medication. The question remains whether this episodic amnestic disorder is comorbid with NF1 or is caused by it

New Signal of Atmospheric Tau Neutrino Appearance: Sub-GeV Neutral-Current Interactions in JUNO

We propose the first practical method to detect atmospheric tau neutrino appearance at sub-GeV energies, which would be an important test of $\nu_\mu \rightarrow \nu_\tau$ oscillations and of new-physics scenarios. In the Jiangmen Underground Neutrino Observatory (JUNO; starts in 2024), active-flavor neutrinos eject neutrons from carbon via neutral-current quasielastic scattering. This produces a two-part signal: the prompt part is caused by the scattering of the neutron in the scintillator, and the delayed part by its radiative capture. Such events have been observed in KamLAND, but only in small numbers and were treated as a background. With $\nu_\mu \rightarrow \nu_\tau$ oscillations, JUNO should measure a clean sample of 55 events/yr; with simple $\nu_\mu$ disappearance, this would instead be 41 events/yr, where the latter is determined from Super-Kamiokande charged-current measurements at similar neutrino energies. Implementing this method will require precise laboratory measurements of neutrino-nucleus cross sections or other developments. With those, JUNO will have $5\sigma$ sensitivity to tau-neutrino appearance in 5 years exposure, and likely sooner.Comment: 12 pages, 8 figure

New constraints on supersymmetry using neutrino telescopes

We demonstrate that megaton-mass neutrino telescopes are able to observe the signal from long-lived particles beyond the Standard Model, in particular the stau, the supersymmetric partner of the tau lepton. Its signature is an excess of charged particle tracks with horizontal arrival directions and energy deposits between 0.1 and 1 TeV inside the detector. We exploit this previously-overlooked signature to search for stau particles in the publicly available IceCube data. The data shows no evidence of physics beyond the Standard Model. We derive a new lower limit on the stau mass of 320 GeV (95% C.L.) and estimate that this new approach, when applied to the full data set available to the IceCube collaboration, will reach word-leading sensitivity to the stau mass (m_{\tilde{t}} = 450GeV)