A Meta-analysis of Attachment to Parents and Delinquency

To investigate the link between attachment to parents and delinquency, and the potential moderating effects of age and sex, 74 published and unpublished manuscripts (N = 55,537 participants) were subjected to a multilevel meta-analysis. A mean small to moderate effect size was found (r = 0.18). Poor attachment to parents was significantly linked to delinquency in boys and girls. Stronger effect sizes were found for attachment to mothers than attachment to fathers. In addition, stronger effect sizes were found if the child and the parent had the same sex compared to cross-sex pairs of children and parents. Age of the participants moderated the link between attachment and delinquency: larger effect sizes were found in younger than in older participants. It can be concluded that attachment is associated with juvenile delinquency. Attachment could therefore be a target for intervention to reduce or prevent future delinquent behavior in juveniles

How long did it last? A 10-year reconviction follow-up study of high intensity training for young offenders

Objectives: Most research has suggested that correctional boot camps are not very successful in reducing reoffending, but recent evidence has been more encouraging for programs that include significant rehabilitative components. In line with this, High Intensity Training (HIT) for offenders aged 18–21 at Thorn Cross Young Offender Institution in England was followed by a significant reduction in the number of reconvictions in a 2-year follow up. This article aims to evaluate the impact of the HIT program after 10 years. Methods: The evaluation used a quasi-experimental design in which male young offenders who received HIT were individually matched, on their risk of reconviction, to a comparison group who went to other prisons. Official reconviction data, including the prevalence, frequency, types, and costs of offenses were used as the outcome measures. Results: Offenders who received HIT had a significantly lower prevalence and frequency of reconvictions, but their superiority over the control group reduced over time (after about 4 years). However, the cumulative number of convictions that were saved increased steadily over time, from 1.35 per offender at 2 years to 3.35 per offender at 10 years. The cumulative cost savings also increased over time, and the benefit:cost ratio, based on fewer convictions, increased from 1.13 at 2 years to 3.93 at 10 years. Conclusions: The beneficial effects of the HIT program became more obvious over time. More randomized experiments and long-term follow-up research, including regular interviews, are needed to evaluate the cumulative and persisting effects of correctional interventions more accurately

Cytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survival

Abstract The nuclear orphan receptor NR4A1 functions as tumour suppressor in aggressive lymphomas by pro-apoptotic genomic and non-genomic effects. Here, we immunohistochemically studied the clinico-pathological relevance of NR4A1 protein expression patterns in a cohort of 60 diffuse large B cell lymphoma (DLBCL) patients and non-neoplastic lymph nodes. We observed a significant association between high cytoplasmic NR4A1 and favourable cancer-specific survival and the germinal centre B cell-like subtype, respectively. Moreover, the percentage of lymphoma cells exhibiting cytoplasmic NR4A1 significantly correlated to those showing cleaved caspase 3. Complementary, functional profiling using gene set enrichment of Reactome pathways based on publicly available microarray data was applied to determine pathways potentially implicated in cytoplasmic localization of NR4A1 and validated by means of semi quantitative real-time PCR. The pathway analysis revealed changes in the ERK1/2 pathway, and this was corroborated by the finding that high cytoplasmic NR4A1 was associated with higher expression of ERK1/2 targets in our cohort. These data indicate that high cytoplasmic NR4A1 is associated with a favourable lymphoma-specific survival and highlights the importance of NR4A1 expression patterns as potential prognostic marker for risk assessment in aggressive lymphomas