2 research outputs found
Spider phobia is associated with decreased left amygdala volume: a cross-sectional study
- Author
- A Anand
- A Etkin
- A Ohman
- A Schienle
- A Schienle
- American Psychiatric Association
- Andrea Federspiel
- B Patenaude
- B Patenaude
- BO Olatunji
- CA Essau
- CD Spielberger
- Dominique J-F de Quervain
- EA Phelps
- EA van der Plas
- F Hayano
- FP MacMaster
- G Franke
- G Massana
- GD Pearlson
- Helge Horn
- JA Chambers
- JG Veening
- JL Freese
- JM Hettema
- K Babalola
- K Blackmon
- L Ossewaarde
- LA Clark
- Leila M Soravia
- M Rinck
- M Rubio-Stipec
- MDM Spampinato
- Melanie S Fisler
- MP Milham
- P Brambilla
- P Muris
- PP Rickham
- PR Szeszko
- R Deichmann
- R Klorman
- RA Morey
- RC Oldfield
- Roland Wiest
- SM Smith
- T Fydrich
- T Straube
- T Straube
- Thomas Dierks
- W Drevets
- WC Drevets
- Wolfgang Schmitt
- YI Sheline
- YI Sheline
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen No
- Aaserud O
- Abbruzzese G
- Acera Gil Ma
- Ackermann O
- Adarmes A
- Agarwal V
- Agosti C
- Akhtar S
- Alaerts N
- Alarcón Md
- Albanese A
- Allain P
- Almagro Ca
- Almeida M
- Alonso-Frech F
- Alusi S
- Anderson M
- Andersson C
- Andrade C
- Andrew A
- Andrews T
- Andrews T
- Andrich J
- Anheim M
- Anjum U
- Anna Bryl Ja
- Annic A
- Antczak J
- Antequera Torres Mm
- Antonova V
- Arbelo Jm
- Arkuszewski M
- Armstrong R
- Armstrong R
- Arntsen V
- Arques Pn
- Arran N
- Azulay Jp
- Baake V
- Babiloni B
- Bachmeier M
- Bachoud-Lévi Ac
- Bachoud-Lévi Ac
- Badei F
- Bailey W
- Banaszkiewicz K
- Bandettini di Poggio M
- Bandmann O
- Barbera Ma
- Barker Ra
- Barlati S
- Barral Vm
- Barrero F
- Barrett W
- Barth K
- Barth K
- Barthélémy R
- Bartoli C
- Barun N
- Bas J
- Bascuñana M
- Becanovic K
- Bechtel N
- Beckmann H
- Bek J
- Bellonet M
- Benaich S
- Benaminov S
- Benito Dm
- Bentivoglio Ar
- Bentivoglio Ar
- Berglund M
- Berglund M
- Berglund P
- Bergmann U
- Bernal-Escudero M
- Bernard T
- Bertini E
- Bethwaite P
- Betz S
- Beuth M
- Bezdíček O
- Bijlsma Emilia K
- Bioux S
- Biunno I
- Björnsson E
- Bjørgo K
- Bjørnevoll I
- Bled D
- Bliaux E
- Blin S
- Blinkenberg Eø
- Blondeau L
- Boczarska-Jedynak M
- Boelmans K
- Bohlen S
- Boissé Mf
- Bojakowska-Jaremek K
- Bojarsky Jk
- Bonelli Rm
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- Bonneau D
- Boogaerts A
- Boogaerts A
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- Bosredon C
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- Boudali L
- Bove F
- Boćwińska D
- Bradbury A
- Braunwarth Em
- Brice A
- Brockie P
- Bronzova J
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- Brugada Fc
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- Bruno S
- Bruun A
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- Buck A
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- Buratti L
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- Burgunder Jm
- Burgunder Jm
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- Busquets N
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- Butcher C
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- Böringer R
- Bürk K
- Błaszczyk M
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- Calopa M
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- Castaldo A
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- Cheriet S
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- Coarelli G
- Codella V
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- De Bruycker C
- de Die-Smulders Christine Em
- De Gregorio F
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- de Tommaso M
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- Dec M
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- Demonet Jf
- Depelchin A
- Derost P
- Descals Am
- Destee A
- Dewulf-Pasz N
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- Di Donato S
- Di Giacopo R
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- Diago Eb
- Dias M
- Diercks G
- Difruscolo O
- Dipple H
- Dixon K
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- Diéguez E
- Doherty K
- Dondaine T
- Donovan Jo
- Dose M
- Dougherty A
- Downie L
- Dramstad E
- Dressler D
- Duché C
- Duffell A
- Dugauquier F
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- Eddy C
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- El-Nimr G
- Elifani F
- Ellrichmann G
- Esmaeilzadeh M
- Esposito C
- Esposito F
- Eusebio A
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- Fannemel M
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- Ferrandes G
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- Ferrer Pq
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- Finisterra Am
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- Gayde-Stephan S
- Geitner C
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- Germain V
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- Gillardin Af
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- Gogol Formerly Kalbarczyk A
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- Gorzolla H
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- Herranhof B
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- Kaiserova M
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- Walleczek Am
- Wannepain S
- Warner T
- Wasielewska A
- Weber N
- Weckx P
- Weekes R
- Weekes R
- Wehus R
- Weindl A
- Wenning G
- Wermuth L
- Werner Cj
- Westman L
- Westmoreland L
- Weydt P
- Whaite A
- Wider C
- Widner H
- Wiklund L
- Wikström B
- Wild E
- Wild S
- Williams J
- Winkelmann J
- Winkler J
- Winnberg E
- Witjes-Ané Mn
- Witjes-Ané Mn
- Witkowski G
- Witkowski G
- Wiśniewski B
- Wolz A
- Wolz M
- Wood J
- Wood S
- Wright A
- Wright A
- Wright J
- Wójcik M
- Yardumian P
- Yates S
- Youssov K
- Yudina E
- Yudina E
- Zalyalova Z
- Zaremba J
- Zaremba J
- Zaugg Sw
- Zdzienicka E
- Zea Sevilla Ma
- Ziegler C
- Zielonka D
- Zielonka D
- Zielonka E
- Zimmermann Ma
- Zinzi P
- Zinzi P
- Zinzi P
- Ziora-Jakutowicz K
- Zittel S
- Zouitina Y
- Zucker B
- Åman J
- Østern R
- Šašinková P
- Šenkárová Z
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30\u201350 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of 6435 or a UHDRS motor score of 645 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, 120.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients