10 research outputs found
Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8+ T cells during MCMV infection
Get PDFNatural killer (NK) cells play a crucial role in early immune response against cytomegalovirus infection. A large and mounting body of data indicate that these cells are involved in the regulation of the adaptive immune response as well. By using mouse cytomegalovirus (MCMV) as a model, several groups provided novel insights into the role of NK cells in the development and kinetics of antiviral CD8+ T cell response. Depending on infection conditions, virus strain and the genetic background of mice used, NK cells are either positive or negative regulators of the CD8+ T cell response. At present, there is no unique explanation for the observed differences between various experimental systems used. In this review we discuss the mechanisms involved in the interplay between NK and CD8+ T cells in the early control of MCMV infection
Rapid discrimination of MHC class I and killer cell lectin-like receptor allele variants by high-resolution melt analysis
No full textUncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection
No full textUncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection
No full textThe green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells
No full textGeneration of cellular immune memory and B-cell immunity is impaired by natural killer cells
No full textThe specific NK cell response in concert with perforin prevents CD8+ T cell-mediated immunopathology after mouse cytomegalovirus infection
No full text
