Evolving uses of oral reverse transcriptase inhibitors in the HIV-1 epidemic: From treatment to prevention

The HIV epidemic continues unabated, with no highly effective vaccine and no cure. Each new infection has significant economic, social and human costs and prevention efforts are now as great a priority as global antiretroviral therapy (ART) scale up. Reverse transcriptase inhibitors, the first licensed class of ART, have been at the forefront of treatment and prevention of mother to child transmission over the past two decades. Now, their use in adult prevention is being

The Atacama Cosmology Telescope: A Catalog of >4000 Sunyaev–Zel’dovich Galaxy Clusters

We present a catalog of 4195 optically confirmed Sunyaev-Zel’dovich (SZ) selected galaxy clusters detected with signal-to-noise > 4 in 13,211 deg2 of sky surveyed by the Atacama Cosmology Tele- scope (ACT). Cluster candidates were selected by applying a multi-frequency matched filter to 98 and 150 GHz maps constructed from ACT observations obtained from 2008–2018, and confirmed us- ing deep, wide-area optical surveys. The clusters span the redshift range 0.04 < z < 1.91 (median z = 0.52). The catalog contains 222 z > 1 clusters, and a total of 868 systems are new discoveries. Assuming an SZ-signal vs. mass scaling relation calibrated from X-ray observations, the sample has a 90% completeness mass limit of M500c > 3.8 × 1014 M , evaluated at z = 0.5, for clusters detected at signal-to-noise ratio > 5 in maps filtered at an angular scale of 2.4′. The survey has a large overlap with deep optical weak-lensing surveys that are being used to calibrate the SZ-signal mass-scaling relation, such as the Dark Energy Survey (4566 deg2), the Hyper Suprime-Cam Subaru Strategic Program (469 deg2), and the Kilo Degree Survey (825 deg2). We highlight some noteworthy objects in the sample, including potentially projected systems; clusters with strong lensing features; clusters with active cen- tral galaxies or star formation; and systems of multiple clusters that may be physically associated. The cluster catalog will be a useful resource for future cosmological analyses, and studying the evolution of the intracluster medium and galaxies in massive clusters over the past 10 Gyr