Prevalence of malaria parasites, Hepatitis B and C viral infections in pregnant women attending anti-natal clinic

No Abstract

Detection of Anti-HBV and Anti-HCV in sera of subjects with evidence of normal or abnormal liver assessment results

No Abstract

Evaluation of some cellular immune index in HIV infected participants

The study was designed to evaluate some cellular immune index of HIV infected participants. 80 HIV infected participants aged between 15 - 65 were recruited for the study. 45 of these participants were classifiedas Symptomatic HIV (Stage 11), while the remaining 35 were Asymptomatic HIV (Stage 1). Similarly, 40 HIV seronegative participants served as Control. Blood samples collected from the participants were used for HIV screening and confirmation, CD4+ T cell count, absolute lymphocyte count and percent lymphocyte transformation. The CD4+T cell count and percent Lymphocyte Transformation count were significantly lowered in HIV infected participants compared with the HIV seronegative participants (p<0.05 in each case).Symptomatic HIV seropositive participants also presented with lowered CD4 and percent lymphocyte transformation, compared with the asymptomatic HIV participants (p<0.05 in each case). The lowered CD4+T cell count suggests possible destruction of cellular immune cells (mainly Th1 cells). While the lowered percent blast formation in HIV infection indicates functional derangement of the cellular immune cells. Meanwhile no significant difference was observed in absolute lymphocyte count among the symptomatic, asymptomatic and control participants (p> 0.05)

Pattern of serum amylase activity in HIV seropositive subjects on anti-retroviral therapy

The present study was designed to assess the impact of antiretroviral therapy (ART) combinations of Nevirepine, Lamivudine and stavudine on the pancrease using serum amylase activity as indicator for pancreatic impairment. For this study 20 symptomatic HIV subjects (female =12, male=8) were recruited prior to ART and followed-up for 4 months into ART. Similarly, 20 HIV seronegative subjects (female =10, male =10) were also recruited as control subjects. Blood sample was collected at pre-ART, 2 months and 4 months into ART from the symptomatic HIV subjects but once from the control subjects for HIV screening, determination of CD4+T cell and serum amylase activity using standard laboratory methods. The result showed significant serum amylase activity by 4 months into ART compared with corresponding value in the control subjects (p0.1). sex distribution showed significant serum amylase activity amongst the male symptomatic HIV subjects by 4 months into ART (

CD4+ T-cells count in HIV-malaria co-infection in adult population in Nnewi, South Eastern Nigeria

The study was designed to evaluate CD4+ T-cells count in subjects with HIV-malaria co-infection in Nnewi, South Eastern Nigeria and to assess the effects any changes in CD4+ counts has on the prevalence andor severity of both illness. Two hundred and eighty-five participants aged between 16 and 72 years were recruited for the study and grouped as symptomatic HIV subjects, asymptomatic HIV subjects, HIV/AIDSsubjects on ART (Antiretroviral Therapy) and HIV-seronegative subjects. HIV and malaria parasite screening, CD4+ T-cell count and parasite density were determined using standard laboratory methods. The result showed that the prevalence of malaria infection was 75% in symptomatic HIV, 46.7% in asymptomatic HIV and 59.6% in HIV/AIDS subjects on ART respectively as opposed to 26.9% observed in the control (