Treatment of Writer's Cramp with Botulinum Toxin Type A

Writer's cramp is the most common form of task-specific dystonia. It can cause severe disability in writing speed/fluency. Treatment approaches are variable. Orally administered drugs, different non-pharmacological methods like stereotactic surgery are possible treatment options, but botulinum toxin seems to be the most effective choice. (Archives of Neuropsychiatry 2010; 47 Supplement: 27-9

Use of Botulinum Toxin Type a in the Treatment of Spasticity

Spasticity is a component of the upper motor neuron syndrome and occurs after maladaptive improvement. Velocity-dependent increase in muscle tonus causes restricted movement, muscle shortness, pain, joint malpositions and contractures. When spasticity is harmful, it has to be treated. The treatment of spasticity requires a multidisciplinary approach. Botulinum toxin type A is effective when used with other treatment modalities, especially with physiotherapy. (Archives of Neuropsychiatry 2010; 47 Supplement: 40-3

Sensorimotor Integration During Motor Learning: Transcranial Magnetic Stimulation Studies

WOS: 000419359800015PubMed ID: 29321712The effect of sensory signals coming from skin and muscle afferents on the sensorimotor cortical networks is entitled as sensory-motor integration (SMI). SMI can be studied electrophysiologically by the motor cortex excitability changes in response to peripheral sensory stimulation. These changes include the periods of short afferent inhibition (SAI), afferent facilitation (AF), and late afferent inhibition (LAI). During the early period of motor skill acquisition, motor cortex excitability increases and changes occur in the area covered by the relevant zone of the motor cortex. In the late period, these give place to the morphological changes, such as synaptogenesis. SAI decreases during learning the motor skills, while LAI increases during motor activity. In this review, the role of SMI in the process of motor learning and transcranial magnetic stimulation techniques performed for studying SMI is summarized

Quantitative Electromyography of the Frontalis Muscle

Purpose: Identification of abnormal motor unit potentials (MUP), in particular those caused by myopathic processes, is generally difficult in facial muscles because the MUPs are already low in amplitude and short in duration. Therefore, quantitative measures for the limits of abnormality are needed more frequently for these muscles, especially for the pathological processes predominantly affecting the craniofacial area. In this study, we aimed to determine some quantitative values that may help us to differentiate "myogenic" and "neurogenic" processes in periocular muscles

Tafamidis treatment in a patient with transthyretin amyloidosis due to domino liver transplantation

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Domino liver transplantation (DLT) increase the number of grafts available to treat patients with liver disease. But, this procedure has a risk of transmission of systemic transthyretin (TTR) amyloidosis. A 69-year-old FAP male patient whose complaints started 8 years after DLT was evaluated because of numbness and burning sensation of feet and hands, walking difficulty, dizziness, diarrhea, dry mouth, urinary retention.http://onlinelibrary.wiley.com/doi/10.1111/ene.12497/epd