2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary

Cancer of unknown primary (CUP) is defned as a heterogeneous group of tumours that present with metastasis, and in which attempts to identify the original site have failed. They difer from other primary tumours in their biological features and how they spread, which means that they can be considered a separate entity. There are several hypotheses regarding their origin, but the most plausible explanation for their aggressiveness and chemoresistance seems to involve chromosomal instability. Depending on the type of study done, CUP can account for 2–9% of all cancer patients, mostly 60–75 years old. This article reviews the main clinical, pathological, and molecular studies conducted to analyse and determine the origin of CUP.The main strategies for patient management and treatment, by both clinicians and pathologists, are also addressed.The authors are grateful for the editorial assistance of Dr. Fernando Sánchez-Barbero of HealthCo (Madrid, Spain) in the production of this manuscript. SEOM and SEAP are grateful for the fnancial support for this project in the form of unrestricted grants from Ferrer Diagnostic, OncoDNA and Foundation Medicine/Roche

2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary

Cancer of unknown primary (CUP) is defined as a heterogeneous group of tumours that present with metastasis, and in which attempts to identify the original site have failed. They differ from other primary tumours in their biological features and how they spread, which means that they can be considered a separate entity. There are several hypotheses regarding their origin, but the most plausible explanation for their aggressiveness and chemoresistance seems to involve chromosomal instability. Depending on the type of study done, CUP can account for 2-9% of all cancer patients, mostly 60-75years old. This article reviews the main clinical, pathological, and molecular studies conducted to analyse and determine the origin of CUP. The main strategies for patient management and treatment, by both clinicians and pathologists, are also addressed

Efeito de estresse salino no processo germinativo de sementes de angico (Anadenanthera colubrina).

O objetivo deste trabalho foi avaliar a germinação de sementes de angico (Anadenanthera colubrina) sob diferentes níveis de estresse salino. A salinidade é considerada um dos principais fatores limitantes para crescimento das plantas, e a germinação e o crescimento inicial de plântulas são os estágios de desenvolvimento mais sensíveis à salinidade, sendo influenciados significativamente pela condição de salinidade do solo. Alta concentrações de sais, especialmente de cloreto de sódio (NaCl), pode inibir a germinação por causa da diminuição do potencial osmótico, o que ocasiona prejuízos às demais fases do processo. No presente experimento, as sementes de angico foram distribuídas em substrato papel Germitest, umedecido com cada uma das soluções salinas (0 dS.m-1; 2 dS.m-1; 4 dS.m-1; 8 dS.m-1; 12 dS.m-1; 16 dS.m-1 e 18 dS.m-1). Os rolos obtidos foram mantidos em incubadora B.O.D a 25 °C durante 10 dias. Foi constatada a tolerância das sementes de angico à salinidade obtendo na condutividade de até 8 dS.m-1 germinação superior a 90%

Benchmark Parameters for CMB Polarization Experiments

The recently detected polarization of the cosmic microwave background (CMB) holds the potential for revealing the physics of inflation and gravitationally mapping the large-scale structure of the universe, if so called B-mode signals below 10^{-7}, or tenths of a uK, can be reliably detected. We provide a language for describing systematic effects which distort the observed CMB temperature and polarization fields and so contaminate the B-modes. We identify 7 types of effects, described by 11 distortion fields, and show their association with known instrumental systematics such as common mode and differential gain fluctuations, line cross-coupling, pointing errors, and differential polarized beam effects. Because of aliasing from the small-scale structure in the CMB, even uncorrelated fluctuations in these effects can affect the large-scale B modes relevant to gravitational waves. Many of these problems are greatly reduced by having an instrumental beam that resolves the primary anisotropies (FWHM << 10'). To reach the ultimate goal of an inflationary energy scale of 3 \times 10^{15} GeV, polarization distortion fluctuations must be controlled at the 10^{-2}-10^{-3} level and temperature leakage to the 10^{-4}-10^{-3} level depending on effect. For example pointing errors must be controlled to 1.5'' rms for arcminute scale beams or a percent of the Gaussian beam width for larger beams; low spatial frequency differential gain fluctuations or line cross-coupling must be eliminated at the level of 10^{-4} rms.Comment: 11 pages, 5 figures, submitted to PR

The b→sγγb\to s\gamma\gamma transition in softly broken supersymmetry

We study the effect of supersymmetric contributions to the effective quark transition $b\to s\gamma\gamma$, including leading order QCD effects. We apply the discussion to the decay $B_s\to\gamma\gamma$. Even though one-particle irreducible contributions could play a role, numerical cancelations make the amplitude for the two-photon emission strongly correlated to the $b\to s\gamma$ amplitude which is sharply constrained by experiment. A quite general statement follows: as long as non-standard physics effects appear only in the matching of the Wilson coefficients of the standard effective operator basis, the deviations from the standard model expectations of the decay rates induced by $b\to s\gamma\gamma$ are bound to follow closely the corresponding deviations on $b\to s\gamma$. Effects of new physics are therefore bound to be small.Comment: Latex2e, RevTex, 22 pages, 8 eps figures, comments and references adde

The Complex Puzzle of Interactions Among Functional Food, Gut Microbiota, and Colorectal Cancer

Colorectal cancer exerts a strong influence on the epidemiological panorama worldwide, and it is directly correlated to etiologic factors that are substantiated by genetic and environmental elements. This complex mixture of factors also has a relationship involving the structural dependence and composition of the gut microbiome, leading to a dysbacteriosis process that may evolve to serious modifications in the intestinal lining, eventually causing the development of a neoplasm. The gastrointestinal tract presents defense strategies and immunological properties that interfere in intestinal permeability, inhibiting the bacterial translocation, thus maintaining the integrity of intestinal homeostasis. The modulation of the intestinal microbiome and the extinction of risk factors associated with intestinal balance losses, especially of environmental factors, make cell and defense alterations impossible. This modulation may be conducted by means of functional foods in the diet, especially soluble fibers, polyunsaturated fatty acids, antioxidants and prebiotics that signal immunomodulatory effects in the intestinal microbiota, with preventive and therapeutic action for colorectal cancer. In summary, this review focuses on the importance of dietary modulation of the intestinal microbiota as an instrument for dysbacteriosis and, consequently, for the prevention of colorectal cancer, suggesting anticarcinogenic, and antiangiogenic properties. Among the intestinal modulating agents considered here are functional foods, especially flaxseed, oat and soy, composing a Bioactive Food Compound