Lack of clustering in low-redshift 21-cm intensity maps cross-correlated with 2dF galaxy densities

We report results from 21-cm intensity maps acquired from the Parkes radio telescope and cross-correlated with galaxy maps from the 2dF galaxy survey. The data span the redshift range $0.057<z<0.098$ and cover approximately 1,300 square degrees over two long fields. Cross correlation is detected at a significance of $5.18\sigma$. The amplitude of the cross-power spectrum is low relative to the expected dark matter power spectrum, assuming a neutral hydrogen (HI) bias and mass density equal to measurements from the ALFALFA survey. The decrement is pronounced and statistically significant at small scales. At $k\sim1.5$ $h \mathrm{Mpc^{-1}}$, the cross power spectrum is more than a factor of 6 lower than expected, with a significance of $14.8\,\sigma$. This decrement indicates either a lack of clustering of neutral hydrogen (HI), a small correlation coefficient between optical galaxies and HI, or some combination of the two. Separating 2dF into red and blue galaxies, we find that red galaxies are much more weakly correlated with HI on $k\sim1.5$ $h \mathrm{Mpc^{-1}}$ scales, suggesting that HI is more associated with blue star-forming galaxies and tends to avoid red galaxies.Comment: 12 pages, 3 figures; fixed typo in meta-data title and paper author

Application of an endo-xylanase from Aspergillus japonicus in the fruit juice clarification and fruit peel waste hydrolysis.

The endo-xylanase from Aspergillus japonicus (UFMS 48.136) was purified in a single step using carboximethylcellulose chromatographic column and applied in fruit juice clarification process and fruit peel waste hydrolysis. This purification procedure resulted in 38.9-fold purification of endo-xylanase with 83.3% final yield. MALDITOF analysis confirmed the molecular mass of 32 kDa. The optimal purified endo-xylanase activity was at a range of pH from 5.0 to 6.0 and from 50 to 60 +-C, retaining more than 70% of its activity at all pH studied (3.0?8.0) for 24 h at room temperature. The A. japonicus endo-xylanolytic activity stimulation curve was assayed in the presence of different birchwood xylan concentrations (ranging from 0.02 to 0.5% w/v) and the endoxylanase activity presented a Vmax of 467.4 +- 30.38 &#956;mol/min/mg, with a km of 2.59 +- 0.17 mg/mL, a kcat of 253.95 +- 16.51 s -1 and a kcat/km value of 98.05 +- 4.41 mL s -1 mg -1. The endo-xylanase was activated by Mn2þ (34.5%) and inhibited by Cu2þ (56.9%). The endo-xylanase was activated by &#946;-mercaptoethanol, Triton X-100, Tween-20, Tween-80 and ferulic acid. In the clarification assay, endo-xylanase successfully clarified the juices of mango (51.11%), banana (9.99%) and tangerine (8.54%). Furthermore, the enzyme also hydrolysed all fruit peel wastes that were tested. In summary, A. japonicus endo-xylanase showed potential for applications in fruit juice clarification and in the treatment of fruit peel wastes, and it is a good candidate for the food industry due to its wide pH stability under acidic conditions

An Isotopic Fingerprint of Electron-Phonon Coupling in High-Tc Cuprates

Angle-resolved photoemission spectroscopy with low-energy tunable photons along the nodal direction of oxygen isotope substituted Bi2Sr2CaCu2O8+delta reveals a distinct oxygen isotope shift near the electron-boson coupling "kink" in the electronic dispersion. The magnitude (a few meV) and direction of the kink shift are as expected due to the measured isotopic shift of phonon frequency, which are also in agreement with theoretical expectations. This demonstrates the participation of the phonons as dominant players, as well as pinpointing the most relevant of the phonon branches.Comment: 5 pages, 3 figure

Raman study of carrier-overdoping effects on the gap in high-Tc superconducting cuprates

Raman scattering in the heavily overdoped (Y,Ca)Ba_2Cu_3O_{7-d} (T_c = 65 K) and Bi_2Sr_2CaCu_2O_{8+d} (T_c = 55 K) crystals has been investigated. For the both crystals, the electronic pair-breaking peaks in the A_{1g} and B_{1g} polarizations were largely shifted to the low energies close to a half of 2Delta_0, Delta_0 being the maximum gap. It strongly suggests s-wave mixing into the d-wave superconducting order parameter and the consequent manifestation of the Coulomb screening effect in the B_{1g}-channel. Gradual mixing of s-wave component with overdoping is not due to the change of crystal structure symmetry but a generic feature in all high-T_c superconducting cuprates.Comment: 5 pages, 4 figures, to be published in Phys. Rev. B, Rapid communicaito

Muon Spin Relaxation Studies of Magnetic-Field-Induced Effects in High-TcT_{c} Superconductors

Muon spin relaxation ($\mu$SR) measurements in high transverse magnetic fields ($\parallel \hat c$) revealed strong field-induced quasi-static magnetism in the underdoped and Eu doped (La,Sr)$_{2}$CuO$_{4}$ and La$_{1.875}$Ba$_{0.125}$CuO$_{4}$, existing well above $T_{c}$ and $T_{N}$. The susceptibility-counterpart of Cu spin polarization, derived from the muon spin relaxation rate, exhibits a divergent behavior towards $T \sim 25$ K. No field-induced magnetism was detected in overdoped La$_{1.81}$Sr$_{0.19}$CuO$_{4}$, optimally doped Bi2212, and Zn-doped YBa$_{2}$Cu$_{3}$O$_{7}$.Comment: 4 pages, 4 color figure

Pico in the Wild: Replacing Passwords, One Site at a Time

Passwords are a burden on the user, especially nowadays with an increasing number of accounts and a proliferation of different devices. Pico is a token-based login method that does not ask users to remember any secrets, nor require keyboard entry of one-time passwords. We wish to evaluate its claim of being simultaneously more usable and more secure than passwords, whilst testing its support for frictionless deployment to web-based services. Our main aim is to collect actionable intelligence on how to improve it. In our study, we teamed up with an Alexa Top 500 website, Gyazo, to offer this alternative login mechanism to users intent on performing a real task of image sharing. We focused on the ecological validity of the trial, and gained knowledge both through the challenges of the trial and the results generated. Users appreciated the ability to avoid password entry but the overall benefit was mitigated by the existing measures put in place by Gyazo to minimise the number of times users are presented with a password entry box. Our main finding is that providing enough benefit requires a solution that applies across sites, rather than focusing on authentication for a single site in isolation.We would also like to thank the European Research Council (ERC) for funding this research through grant StG 307224 (Pico) and the Engineering and Physical Sciences Research Council (EPSRC) through grant EP/M019055/1

Deploying authentication in the wild: Towards greater ecological validity in security usability studies

Abstract Pico is a token-based login method that claims to be simultaneously more usable and more secure than passwords. It does not ask users to remember any secrets, nor to type one-time passwords. We evaluate Pico’s claim with two deployments and user studies, one on a web-based service and another within an organization. Our main aim is to collect actionable intelligence on how to improve the usability and deployability of Pico. In our first study we team up with an established website, Gyazo, to offer this alternative login mechanism to users intent on performing a real task of image sharing. From the lessons of this first study, we retarget Pico’s focus from replacing web passwords to replacing desktop login passwords; and thus in our second study we engage with a government organization, Innovate UK, to offer employees the ability to lock and unlock their computer automatically based on proximity. We focus particularly on the ecological validity of the trials and we thereby gain valuable insights into the viability of Pico, not only through the actual responses from the participants but also through the many practical challenges we had to face and overcome. Reflecting on the bigger picture, from our experience we believe the security usability community would greatly benefit from pushing towards greater ecological validity in published work, despite the considerable difficulties and costs involved.This work was supported by the European Research Council (ERC) [StG 307224, Pico, to FMS] and the extended visits of Gyazo inventor and CTO Masui to Cambridge were supported by the Engineering and Physical Sciences Research Council (EPSRC) [EP/M019055/1, Future authentication systems, to FMS]

Pre-M Phase-promoting Factor Associates with Annulate Lamellae in Xenopus Oocytes and Egg Extracts

We have used complementary biochemical and in vivo approaches to study the compartmentalization of M phase-promoting factor (MPF) in prophase Xenopus eggs and oocytes. We first examined the distribution of MPF (Cdc2/CyclinB2) and membranous organelles in high-speed extracts of Xenopus eggs made during mitotic prophase. These extracts were found to lack mitochondria, Golgi membranes, and most endoplasmic reticulum (ER) but to contain the bulk of the pre-MPF pool. This pre-MPF could be pelleted by further centrifugation along with components necessary to activate it. On activation, Cdc2/CyclinB2 moved into the soluble fraction. Electron microscopy and Western blot analysis showed that the pre-MPF pellet contained a specific ER subdomain comprising "annulate lamellae" (AL): stacked ER membranes highly enriched in nuclear pores. Colocalization of pre-MPF with AL was demonstrated by anti-CyclinB2 immunofluorescence in prophase oocytes, in which AL are positioned close to the vegetal surface. Green fluorescent protein-CyclinB2 expressed in oocytes also localized at AL. These data suggest that inactive MPF associates with nuclear envelope components just before activation. This association may explain why nuclei and centrosomes stimulate MPF activation and provide a mechanism for targeting of MPF to some of its key substrates