Life under Siege: Militarized Welfare in U.S.-occupied Okinawa

This dissertation examines the formations of what I have termed “militarized welfare,” that is, the multilayered ways in which discourses and practices of protecting and promoting life became intricately and intimately connected with militarism in Okinawa through the period of U.S. administration (1945-1972). This project draws on, and aims to contribute to, roughly three fields of scholarly literature: the politics of life and death, theorized most explicitly by Michel Foucault; U.S. (and Japanese) Cold War expansionism in the Asia-Pacific; and transpacific militarism. The central argument of my thesis is that the expansion of medical welfare in Okinawa was not antithetical to militarization, but in fact enabled it. I demonstrate this complementary relationship between warfare and welfare by closely examining the lived experiences of agents and subjects of welfare in/for occupied Okinawa – missionaries, medical practitioners, patients, Okinawan diaspora, and displaced farmers. While each actor engaged in promoting and protecting life in their own right, their acts of welfare were often easily appropriated by the U.S. military and U.S. and Japanese governments to serve their respective purposes. My thesis also tries to capture the moments when this affinity between welfare and the military was destabilized by actors who closely observed the limits of medical welfare in Okinawa. Chapter 1 explores the role of American Christianity in occupied Okinawa in producing the narratives of liberation and rehabilitation to transform Okinawa into a place worthy of salvation in the American imagination. Chapter 2 closely examines the lived experiences of public health nurses, illustrating how the education and mobilization of public health nurses constituted part of the biopolitical strategy of the U.S. Cold War empire. Chapter 3 explores the transpacific circuits of care and relief that connected occupied Okinawa, Hawaiʻi and beyond in multifaceted ways. I argue that transpacific biopolitical projects of “nurturing life” were facilitated through the necropolitical network that simultaneously shaped the Pacific in Cold War formations. Chapter 4 focuses on the protest by displaced farmers and shows how land and life itself became an effective basis for the struggle against militarism. However, these movements were soon depoliticized through social security measures.Ph.D

Supplementary Material for: A case of photoimmunotherapy for nasopharyngeal carcinoma requiring emergency tracheostomy

Introduction: Photoimmunotherapy (PIT) is a treatment wherein intravenous cetuximab sarotarocan sodium is administered followed by laser light irradiation. This treatment exhibits a specific antitumor effect if in tumors expressing the epidermal growth factor receptor (EGFR), regardless of the carcinoma [1-3]. The current indications are unresectable, locally advanced, or locally recurrent head and neck cancer. If standard treatments, such as radiotherapy and chemotherapy, are available, they are given priority. However, a significant concern in PIT is the occurrence of airway emergencies related to pharyngeal edema. Prophylactic tracheostomy is often performed in cases of PIT involving the root of the tongue, hypopharynx, or larynx. Case presentation: In this study, we administered transoral PIT to a patient diagnosed with radiation-induced nasopharyngeal carcinoma (squamous cell carcinoma (SCC) cT1N0M0 Stage I). Although previous case reports and our own experiences did not report airway emergencies following PIT for nasopharyngeal carcinoma, a unique case occurred in our study [4,5]. The patient experienced poor oxygenation and a decreased level of consciousness early in the morning following the laser irradiation. Nasal endoscopy revealed airway narrowing due to upper airway edema, and intubation was challenging. Consequently, we performed emergency bedside tracheostomy and the patient’s condition improved. Conclusion: Therefore, it is crucial to note that airway emergencies can be life-threatening and should be diligently monitored as a potential complication of PIT

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

White adipocytes are unique in that they contain large unilocular lipid droplets that occupy most of the cytoplasm. To identify genes involved in the maintenance of mature adipocytes, we expressed dominant-negative PPARγ in 3T3-L1 cells and performed a microarray screen. The fat-specific protein of 27 kDa (FSP27) was strongly downregulated in this context. FSP27 expression correlated with induction of differentiation in cultured preadipocytes, and the protein localized to lipid droplets in murine white adipocytes in vivo. Ablation of FSP27 in mice resulted in the formation of multilocular lipid droplets in these cells. Furthermore, FSP27-deficient mice were protected from diet-induced obesity and insulin resistance and displayed an increased metabolic rate due to increased mitochondrial biogenesis in white adipose tissue (WAT). Depletion of FSP27 by siRNA in murine cultured white adipocytes resulted in the formation of numerous small lipid droplets, increased lipolysis, and decreased triacylglycerol storage, while expression of FSP27 in COS cells promoted the formation of large lipid droplets. Our results suggest that FSP27 contributes to efficient energy storage in WAT by promoting the formation of unilocular lipid droplets, thereby restricting lipolysis. In addition, we found that the nature of lipid accumulation in WAT appears to be associated with maintenance of energy balance and insulin sensitivity