363 research outputs found
Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia : implication for therapy
This work was supported by: Associazione Italiana Ricerca sul Cancro (AIRC) Grant 5 x mille n.9980, (to M.F., F.M. A. N., P.T. and M.N.) ; AIRC I.G. n. 14326 (to M.F.), n.10136 and 16722 (A.N.), n.15426 (to F.F.). AIRC and Fondazione CaRiCal co-financed Multi Unit Regional Grant 2014 n.16695 (to F.M.). Italian Ministry of Health 5x1000 funds (to S.Z. and F.F). A.G R. was supported by Associazione Italiana contro le Leucemie-Linfomi-Mielomi (AIL) Cosenza - Fondazione Amelia Scorza (FAS). S.M. C.M., M.C., L.E., S.B. were supported by AIRC.Peer reviewedPostprin
Cosmological measurements from void-galaxy and galaxy-galaxy clustering in the Sloan Digital Sky Survey
We present the cosmological implications of measurements of void-galaxy and
galaxy-galaxy clustering from the Sloan Digital Sky Survey (SDSS) Main Galaxy
Sample (MGS), Baryon Oscillation Spectroscopic Survey (BOSS), and extended BOSS
(eBOSS) luminous red galaxy catalogues from SDSS Data Release 7, 12, and 16,
covering the redshift range . We fit a standard CDM
cosmological model as well as various extensions including a constant dark
energy equation of state not equal to , a time-varying dark energy equation
of state, and these same models allowing for spatial curvature. Results on key
parameters of these models are reported for void-galaxy and galaxy-galaxy
clustering alone, both of these combined, and all these combined with
measurements from the cosmic microwave background (CMB) and supernovae (SN).
For the combination of void-galaxy and galaxy-galaxy clustering plus CMB and
SN, we find tight constraints of for a
base CDM cosmology, additionally allowing the dark energy equation of state to
vary, and further extending to
non-flat models.Comment: 11 pages, 9 figures. Submitted to MNRA
Microbiota of Deciduous Endodontic Infections Analyzed by MDA and Checkerboard DNA-DNA Hybridization
Aims To evaluate the microbiota of endodontic infections in deciduous teeth by checkerboard DNA-DNA hybridization after uniform amplification of DNA in samples by multiple displacement amplification (MDA). Methodology Forty samples from the root canal system of deciduous teeth exhibiting pulp necrosis with or without radiographically detectable periradicular/interadicular bone resorption were collected and 32 were analyzed, with 3 individuals contributing 2 samples; these were MDA- amplified and analyzed by Checkerboard DNA-DNA hybridization for levels of 83 bacterial taxa. Two outcome measures were used: the percentage of teeth colonized by each species; and the mean proportion of each bacterial taxon present across all samples were computed. Results The mean amount of DNA in the samples prior to amplification was 5.2 (± 4.7) ng and 6.1 (± 2.3) μg after MDA. The mean number of species detected per sample was 19 (± 4) (range: 3–66) to the nearest whole number. The most prevalent taxa were Prevotella intermedia (96.9%), Neisseria mucosa (65.6%), Prevotella nigrescens (56.2%) and Tannerella forsythia (56.2%). Aggregatibacter (Haemophilus) aphrophilus and Helicobacter pylori were not detected. P. intermedia (10%), Prevotella tannerae (7%) and Prevotella nigrescens (4.3%) presented the highest mean proportions of the target species averaged across the positive samples. Conclusion Root canals of infected deciduous teeth had a diverse bacterial population. Prevotella sp were commonly found with P. intermedia, Prevotella tannerae and Prevotella nigrescens among the most prominent species detected
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A Mini Review of the Techno-environmental Sustainability of Biological Processes for the Treatment of High Organic Content Industrial Wastewater Streams
The authors would like to acknowledge the Royal Society for funding the current research: Ad-Bio: Advanced Biological Wastewater Treatment Processes, Newton Advanced Fellowship -2015/R2. Theoni M. Massara is grateful to the Natural Environment Research Council (NERC) of the UK for the 4-year full PhD studentship
Long-term effects of intensive B cell depletion therapy in severe cases of IgG4-related disease with renal involvement
Biomarkers in post-reperfusion syndrome after acute lower limb ischaemia
Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply
returns to the tissue after a period of ischaemia. Matrix metalloproteinases (MMPs),
neutrophil gelatinase-associated lipocalin (NGAL) and cytokines are biomarkers
involved in several vascular complications. The aim of this study was to evaluate the
role of MMPs, NGAL and inflammatory cytokines in I/R syndrome. We conducted an
open label, multicentric, parallel group study, between January 2010 and December
2013. Patients with acute limb ischaemia were enrolled in this study and were divided
into two groups: (i) those subjected to fasciotomy and (ii) those not subjected to fasciotomy,
according to the onset of compartment syndrome. Plasma and tissue values
of MMPs and NGAL as well as plasma cytokines were evaluated. MMPs, NGAL and
cytokine levels were higher in patients with compartment syndrome. Biomarkers evaluated
in this study may be used in the future as predictors of I/R injury severity and its
possible evolution towards post-reperfusion syndrome
Development of Ascaris lumbricoides eggs from females eliminated after chemotherapy in man
The effect of initial pH and retention time on boron removal by continuous electrocoagulation process
In this study, factors influencing boron removal via the continuous electrocoagulation process were investigated at lab-scale. Different influent pH values (4, 5, 6, 7.45 and 9) and contact times (10, 25, 50 and 100 min) were examined as variable parameters. Plate-type aluminium electrodes with 5 mm distance between them were used. All the experiments were conducted in continuous mode and the current density was kept constant at 5 A throughout the whole experimental period. The initial boron concentration was selected to be 1000 mg L-1. The first set of experiments concerning the influence of the influent pH showed that the highest boron removal (67%) was obtained at pH=6 since it was the optimal pH for boron precipitation through aluminium borate formation. Under the constant current density of the study and with the initial pH adjusted to 6, increasing the duration of the electrocoagulation process from 10 to 100 min resulted in raising the boron removal from 45 to 79% during the second set of experiments. The greater duration of the electrocagulation process enabled higher aluminium dissolution, thus allowing the existence of a higher number of coagulants within the reactor. Moreover, it enhanced boron precipitation because of the longer contact time between the boron ions and the coagulants. After optimizing significant parameters such as the influent pH and the electrocagulation duration, the continuous electrocoagulation process was found to constitute an effective alternative for boron removal
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Removal of Heavy Metals by a Membrane Bioreactor Combined with Activated Carbon
Royal Society; Ad-Bio: Advanced Biological Wastewater Treatment Processes; Natural Environment Research Council (NERC): Newton Advanced Fellowship - 2015/R2
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