Syntheses and Properties of Crosslinked Ferrocene Polymers(Chemistry)

The polycondensation reaction of acetylferrocene and furfural was investigated in the presence of concentrated H_2SO_4 as a catalyst without solvent. Stoichiometric reaction took place with 2 mol of acetylferrocene and 5 mol of furfural. Poly-condensation afforded satisfactory results when 1 mol of acetylferrocene was treated with 2-7 mol of furfural. The structural evidence for these products was derived from chemical and infrared analyses. Density, micro Vickers hardness, magnetic susceptibility, and thermal behavior of these products were measured in comparison with those of other resins

Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of retinal tissues in a streptozotocin-induced diabetic rat model.

In order to clarify the mechanism of retinal tissue damage in diabetes mellitus, the effects of the inhibition of aldose reductase on the pathologic changes in the retina of streptozotocin-induced diabetic (STZ-diabetic) rats were examined histologically and histochemically. The STZ-diabetic animals were maintained with and without peroral administration of an aldose reductase inhibitor, SNK-860, and their retinas were examined microscopically after 12 months. Several abnormal changes observed; folding and edema in the retina, loss of pericytes in the retinal capillary walls, and thickening of basement membranes in the retinal capillaries, were significantly inhibited by SNK-860. Some of these changes were similar to those that had been previously noted in diabetic and galactosemic rats. These data suggest that the enhanced polyol metabolism may be involved in the diabetic changes of the retina.</p